diff --git a/pkgs/development/python-modules/py-libzfs/default.nix b/pkgs/development/python-modules/py-libzfs/default.nix
new file mode 100644
index 000000000000..21663ba80238
--- /dev/null
+++ b/pkgs/development/python-modules/py-libzfs/default.nix
@@ -0,0 +1,44 @@
+{ lib
+, stdenv
+, buildPythonPackage
+, fetchFromGitHub
+, cython
+, zfs
+}:
+
+buildPythonPackage rec {
+  pname = "py-libzfs";
+  version = "22.02.4";
+
+  src = fetchFromGitHub {
+    owner = "truenas";
+    repo = pname;
+    rev = "TS-${version}";
+    sha256 = "sha256-BJG+cw07Qu4aL99pVKNd7JAgr+w/6Uv2eI46EB615/I=";
+  };
+
+  nativeBuildInputs = [ cython ];
+  buildInputs = [ zfs ];
+
+  # Passing CFLAGS in configureFlags does not work, see https://github.com/truenas/py-libzfs/issues/107
+  postPatch = lib.optionalString stdenv.isLinux ''
+    substituteInPlace configure \
+      --replace \
+        'CFLAGS="-DCYTHON_FALLTHROUGH"' \
+        'CFLAGS="-DCYTHON_FALLTHROUGH -I${zfs.dev}/include/libzfs -I${zfs.dev}/include/libspl"' \
+      --replace 'zof=false' 'zof=true'
+  '';
+
+  pythonImportsCheck = [ "libzfs" ];
+
+  meta = with lib; {
+    description = "Python libzfs bindings";
+    homepage = "https://github.com/truenas/py-libzfs";
+    license = licenses.bsd2;
+    maintainers = with maintainers; [ chuangzhu ];
+    # The project also supports macOS (OpenZFS on OSX, O3X), FreeBSD and OpenSolaris
+    # I don't have a machine to test out, thus only packaged for Linux
+    platforms = platforms.linux;
+  };
+}
+
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index a65466b0cdca..58b814a21b59 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8113,6 +8113,8 @@ in {
 
   pylitterbot = callPackage ../development/python-modules/pylitterbot { };
 
+  py-libzfs = callPackage ../development/python-modules/py-libzfs { };
+
   py-lru-cache = callPackage ../development/python-modules/py-lru-cache { };
 
   pylnk3 = callPackage ../development/python-modules/pylnk3 { };