diff --git a/pkgs/development/python-modules/mouseinfo/default.nix b/pkgs/development/python-modules/mouseinfo/default.nix
new file mode 100644
index 000000000000..5279165b2f1d
--- /dev/null
+++ b/pkgs/development/python-modules/mouseinfo/default.nix
@@ -0,0 +1,40 @@
+{ lib
+, buildPythonPackage
+, pyperclip
+, fetchFromGitHub
+, xlib
+, pillow
+}:
+buildPythonPackage rec {
+  pname = "MouseInfo";
+  version = "0.1.3";
+
+  src = fetchFromGitHub {
+    owner = "asweigart";
+    repo = "mouseinfo";
+    rev = "1876ad5cd311b4352d46bc64a12edfb4da49974e";
+    sha256 = "sha256-UTaHTJE0xFihN9r+DY/WhekZ7S/CXtMFbqAayzexRxk=";
+  };
+
+  patches = [
+    ./fix-xlib-version.patch
+    ./pillow-version.patch
+  ];
+
+  doCheck = false;
+  # Mouseinfo requires a X server running to import succesfully
+  # pythonImportsCheck = [ "mouseinfo" ];
+
+  propagatedBuildInputs = [
+    pyperclip
+    xlib
+    pillow
+  ];
+
+  meta = with lib; {
+    description = "An application to display XY position and RGB color information for the pixel currently under the mouse. Works on Python 2 and 3.";
+    homepage = "https://github.com/asweigart/mouseinfo";
+    license = licenses.gpl3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/development/python-modules/mouseinfo/fix-xlib-version.patch b/pkgs/development/python-modules/mouseinfo/fix-xlib-version.patch
new file mode 100644
index 000000000000..d6bd5f71ac57
--- /dev/null
+++ b/pkgs/development/python-modules/mouseinfo/fix-xlib-version.patch
@@ -0,0 +1,14 @@
+diff --git a/setup.py b/setup.py
+index 37d5f77..894fe78 100644
+--- a/setup.py
++++ b/setup.py
+@@ -31,8 +31,7 @@ setup(
+     test_suite='tests',
+     # NOTE: Update the python_version info for Pillow as Pillow supports later versions of Python.
+     install_requires=['rubicon-objc;platform_system=="Darwin"',
+-                      'python3-Xlib;platform_system=="Linux" and python_version>="3.0"',
+-                      'Xlib;platform_system=="Linux" and python_version<"3.0"',
++                      'python-Xlib;platform_system=="Linux"',
+                       'pyperclip',
+                       'Pillow >= 6.2.1; python_version == "3.8"',
+                       'Pillow >= 5.2.0; python_version == "3.7"',
diff --git a/pkgs/development/python-modules/mouseinfo/pillow-version.patch b/pkgs/development/python-modules/mouseinfo/pillow-version.patch
new file mode 100644
index 000000000000..b8abb02695f4
--- /dev/null
+++ b/pkgs/development/python-modules/mouseinfo/pillow-version.patch
@@ -0,0 +1,20 @@
+diff --git a/setup.py b/setup.py
+index 894fe78..ac580a6 100644
+--- a/setup.py
++++ b/setup.py
+@@ -33,14 +33,7 @@ setup(
+     install_requires=['rubicon-objc;platform_system=="Darwin"',
+                       'python-Xlib;platform_system=="Linux"',
+                       'pyperclip',
+-                      'Pillow >= 6.2.1; python_version == "3.8"',
+-                      'Pillow >= 5.2.0; python_version == "3.7"',
+-                      'Pillow >= 4.0.0; python_version == "3.6"',
+-                      'Pillow >= 3.2.0; python_version == "3.5"',
+-                      'Pillow <= 5.4.1, >= 2.5.0; python_version == "3.4"',
+-                      'Pillow <= 4.3.0, >= 2.0.0; python_version == "3.3"',
+-                      'Pillow <= 3.4.2, >= 2.0.0; python_version == "3.2"',
+-                      'Pillow >= 2.0.0; python_version == "2.7"',
++                      'Pillow',
+                       ],
+     keywords='',
+     classifiers=[
diff --git a/pkgs/development/python-modules/pyautogui/default.nix b/pkgs/development/python-modules/pyautogui/default.nix
new file mode 100644
index 000000000000..08ab81ba93d3
--- /dev/null
+++ b/pkgs/development/python-modules/pyautogui/default.nix
@@ -0,0 +1,59 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, python3Packages
+, pkgs
+, fetchzip
+, mouseinfo
+, pygetwindow
+, pymsgbox
+, pyperclip
+, pyrect
+, pyscreeze
+, pytweening
+, tkinter
+, xlib
+, xvfb-run
+, scrot
+}:
+buildPythonPackage rec {
+  pname = "pyautogui";
+  version = "0.9.53";
+
+  src = fetchFromGitHub {
+    owner = "asweigart";
+    repo = "pyautogui";
+    rev = "5e4acb870f2e7ce0ea1927cc5188bc2f5ab7bbbc";
+    sha256 = "sha256-R9tcTqxUaqw63FLOGFRaO/Oz6kD7V6MPHdQ8A29NdXw=";
+  };
+
+  checkInputs = [ xvfb-run scrot ];
+  checkPhase = ''
+    xvfb-run python -c 'import pyautogui'
+    # The tests depend on some specific things that xvfb cant provide, like keyboard and mouse
+    # xvfb-run python -m unittest tests.test_pyautogui
+  '';
+
+  patches = [
+    # https://github.com/asweigart/pyautogui/issues/598
+    ./fix-locateOnWindow-and-xlib.patch
+  ];
+
+  propagatedBuildInputs = [
+    mouseinfo
+    pygetwindow
+    pymsgbox
+    xlib
+    tkinter
+    pyperclip
+    pyscreeze
+    pytweening
+  ];
+
+  meta = with lib; {
+    description = "PyAutoGUI lets Python control the mouse and keyboard, and other GUI automation tasks.";
+    homepage = "https://github.com/asweigart/pyautogui";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/development/python-modules/pyautogui/fix-locateOnWindow-and-xlib.patch b/pkgs/development/python-modules/pyautogui/fix-locateOnWindow-and-xlib.patch
new file mode 100644
index 000000000000..ef0c02892238
--- /dev/null
+++ b/pkgs/development/python-modules/pyautogui/fix-locateOnWindow-and-xlib.patch
@@ -0,0 +1,30 @@
+diff --git a/pyautogui/__init__.py b/pyautogui/__init__.py
+index ec7d097..443b146 100644
+--- a/pyautogui/__init__.py
++++ b/pyautogui/__init__.py
+@@ -216,9 +216,9 @@ try:
+ 
+     @raisePyAutoGUIImageNotFoundException
+     def locateOnWindow(*args, **kwargs):
+-        return pyscreeze.locateOnWindow(*args, **kwargs)
++        return pyscreeze.locateOnScreen(*args, **kwargs)
+ 
+-    locateOnWindow.__doc__ = pyscreeze.locateOnWindow.__doc__
++    locateOnWindow.__doc__ = pyscreeze.locateOnScreen.__doc__
+ 
+ 
+ except ImportError:
+diff --git a/setup.py b/setup.py
+index 196394d..6d90a88 100644
+--- a/setup.py
++++ b/setup.py
+@@ -29,8 +29,7 @@ setup(
+     test_suite='tests',
+     install_requires=['pyobjc-core;platform_system=="Darwin"',
+                       'pyobjc;platform_system=="Darwin"',
+-                      'python3-Xlib;platform_system=="Linux" and python_version>="3.0"',
+-                      'python-xlib;platform_system=="Linux" and python_version<"3.0"',
++                      'python-xlib;platform_system=="Linux"',
+                       'pymsgbox',
+                       'PyTweening>=1.0.1',
+                       'pyscreeze>=0.1.21',
diff --git a/pkgs/development/python-modules/pygetwindow/default.nix b/pkgs/development/python-modules/pygetwindow/default.nix
new file mode 100644
index 000000000000..3ca462115768
--- /dev/null
+++ b/pkgs/development/python-modules/pygetwindow/default.nix
@@ -0,0 +1,29 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, pyrect
+}:
+buildPythonPackage rec {
+  pname = "PyGetWindow";
+  version = "0.0.9";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "sha256-F4lDVefSswXNgy1xdwg4QBfBaYqQziT29/vwJC3Qpog=";
+  };
+
+  doCheck = false;
+  # This lib officially only works completely on Windows and partially on MacOS but pyautogui requires it
+  # pythonImportsCheck = [ "pygetwindow" ];
+
+  propagatedBuildInputs = [
+    pyrect
+  ];
+
+  meta = with lib; {
+    description = "A simple, cross-platform module for obtaining GUI information on applications' windows.";
+    homepage = "https://github.com/asweigart/PyGetWindow";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/development/python-modules/pymsgbox/default.nix b/pkgs/development/python-modules/pymsgbox/default.nix
index 84ab3dcab1bf..760a339b90af 100644
--- a/pkgs/development/python-modules/pymsgbox/default.nix
+++ b/pkgs/development/python-modules/pymsgbox/default.nix
@@ -2,18 +2,18 @@
 
 buildPythonPackage rec {
   pname = "PyMsgBox";
-  version = "1.0.6";
+  version = "1.0.9";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "0kmd00w7p6maiyqpqqb2j8m6v2gh9c0h5i198pa02bc1c1m1321q";
-    extension = "zip";
+    sha256 = "sha256-IZQifei/96PW2lQYSHBaFV3LsqBu4SDZ8oCh1/USY/8=";
   };
 
   propagatedBuildInputs = [ tkinter ];
 
   # Finding tests fails
   doCheck = false;
+  pythonImportsCheck = [ "pymsgbox" ];
 
   meta = with lib; {
     description = "A simple, cross-platform, pure Python module for JavaScript-like message boxes";
diff --git a/pkgs/development/python-modules/pyperclip/default.nix b/pkgs/development/python-modules/pyperclip/default.nix
index c04cc9eec346..7f91cc8aecce 100644
--- a/pkgs/development/python-modules/pyperclip/default.nix
+++ b/pkgs/development/python-modules/pyperclip/default.nix
@@ -13,7 +13,7 @@ buildPythonPackage rec {
 
   meta = with lib; {
     homepage = "https://github.com/asweigart/pyperclip";
-    license = licenses.bsdOriginal;
+    license = licenses.bsd3;
     description = "Cross-platform clipboard module";
   };
 }
diff --git a/pkgs/development/python-modules/pyrect/default.nix b/pkgs/development/python-modules/pyrect/default.nix
new file mode 100644
index 000000000000..e8041786b07b
--- /dev/null
+++ b/pkgs/development/python-modules/pyrect/default.nix
@@ -0,0 +1,29 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, tox
+, pytestCheckHook
+, pygame
+}:
+buildPythonPackage rec {
+  pname = "PyRect";
+  version = "0.1.4";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "sha256-Oy+nNTzjKhGqawoVSVlo0qdjQjyJR64ki5LAN9704gI=";
+  };
+
+  checkInputs = [ tox pytestCheckHook pygame ];
+  pythonImportsCheck = [ "pyrect" ];
+  preCheck = ''
+    export LC_ALL="en_US.UTF-8"
+  '';
+
+  meta = with lib; {
+    description = "Simple module with a Rect class for Pygame-like rectangular areas";
+    homepage = "https://github.com/asweigart/pyrect";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/development/python-modules/pyscreeze/default.nix b/pkgs/development/python-modules/pyscreeze/default.nix
new file mode 100644
index 000000000000..ddca8e72c23f
--- /dev/null
+++ b/pkgs/development/python-modules/pyscreeze/default.nix
@@ -0,0 +1,37 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pillow
+, xlib
+, xvfb-run
+, scrot
+}:
+buildPythonPackage rec {
+  pname = "PyScreeze";
+  version = "0.1.26";
+
+  src = fetchFromGitHub {
+    owner = "asweigart";
+    repo = "pyscreeze";
+    rev = "28ab707dceecbdd135a9491c3f8effd3a69680af";
+    sha256 = "sha256-gn3ydjf/msdhIhngGlhK+jhEyFy0qGeDr58E7kM2YZs=";
+  };
+
+  pythonImportsCheck = [ "pyscreeze" ];
+  checkInputs = [ scrot xlib xvfb-run ];
+  checkPhase = ''
+    python -m unittest tests.test_pillow_unavailable
+    xvfb-run python -m unittest tests.test_pyscreeze
+  '';
+
+  propagatedBuildInputs = [
+    pillow
+  ];
+
+  meta = with lib; {
+    description = "PyScreeze is a simple, cross-platform screenshot module for Python 2 and 3.";
+    homepage = "https://github.com/asweigart/pyscreeze";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/development/python-modules/pytweening/default.nix b/pkgs/development/python-modules/pytweening/default.nix
new file mode 100644
index 000000000000..d0ba9803063b
--- /dev/null
+++ b/pkgs/development/python-modules/pytweening/default.nix
@@ -0,0 +1,25 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+}:
+buildPythonPackage rec {
+  pname = "pytweening";
+  version = "1.0.4";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "sha256-hTMoLPcLMd6KBJnhz0IJMLABPHhxGIcrLsiZOCeS4uY=";
+  };
+
+  pythonImportsCheck = [ "pytweening" ];
+  checkPhase = ''
+    python -m unittest tests.basicTests
+  '';
+
+  meta = with lib; {
+    description = "Set of tweening / easing functions implemented in Python";
+    homepage = "https://github.com/asweigart/pytweening";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ lucasew ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b05183e99425..e7825d77fea6 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4946,6 +4946,8 @@ in {
 
   motor = callPackage ../development/python-modules/motor { };
 
+  mouseinfo = callPackage ../development/python-modules/mouseinfo { };
+
   moviepy = callPackage ../development/python-modules/moviepy { };
 
   mox3 = callPackage ../development/python-modules/mox3 { };
@@ -6261,6 +6263,8 @@ in {
 
   pyaudio = callPackage ../development/python-modules/pyaudio { };
 
+  pyautogui = callPackage ../development/python-modules/pyautogui { };
+
   pyavm = callPackage ../development/python-modules/pyavm { };
 
   pyaxmlparser = callPackage ../development/python-modules/pyaxmlparser { };
@@ -6568,6 +6572,8 @@ in {
 
   pygeoip = callPackage ../development/python-modules/pygeoip { };
 
+  pygetwindow = callPackage ../development/python-modules/pygetwindow { };
+
   pygit2 = callPackage ../development/python-modules/pygit2 { };
 
   PyGithub = callPackage ../development/python-modules/pyGithub { };
@@ -7077,6 +7083,8 @@ in {
     pythonPackages = self;
   });
 
+  pyrect = callPackage ../development/python-modules/pyrect { };
+
   pyregion = callPackage ../development/python-modules/pyregion { };
 
   pyres = callPackage ../development/python-modules/pyres { };
@@ -7147,6 +7155,8 @@ in {
 
   pyscreenshot = callPackage ../development/python-modules/pyscreenshot { };
 
+  pyscreeze = callPackage ../development/python-modules/pyscreeze { };
+
   py_scrypt = callPackage ../development/python-modules/py_scrypt { };
 
   pyscrypt = callPackage ../development/python-modules/pyscrypt { };
@@ -7878,6 +7888,8 @@ in {
 
   pyturbojpeg = callPackage ../development/python-modules/pyturbojpeg { };
 
+  pytweening = callPackage ../development/python-modules/pytweening { };
+
   pytwitchapi = callPackage ../development/python-modules/pytwitchapi { };
 
   pytz = callPackage ../development/python-modules/pytz { };