diff --git a/pkgs/development/libraries/mesa/default.nix b/pkgs/development/libraries/mesa/default.nix
index cf0451790707..24ce9ff20771 100644
--- a/pkgs/development/libraries/mesa/default.nix
+++ b/pkgs/development/libraries/mesa/default.nix
@@ -9,7 +9,7 @@
 , galliumDrivers ? ["auto"]
 , vulkanDrivers ? ["auto"]
 , eglPlatforms ? [ "x11" ] ++ lib.optionals stdenv.isLinux [ "wayland" ]
-, vulkanLayers ? [ "device-select" "overlay" ]
+, vulkanLayers ? lib.optionals (!stdenv.isDarwin) [ "device-select" "overlay" ] # No Vulkan support on Darwin
 , OpenGL, Xplugin
 , withValgrind ? lib.meta.availableOn stdenv.hostPlatform valgrind-light && !valgrind-light.meta.broken, valgrind-light
 , enableGalliumNine ? stdenv.isLinux