diff --git a/pkgs/by-name/at/atril/package.nix b/pkgs/by-name/at/atril/package.nix
index a985a62bb7f3..3b735d94df78 100644
--- a/pkgs/by-name/at/atril/package.nix
+++ b/pkgs/by-name/at/atril/package.nix
@@ -88,6 +88,12 @@ stdenv.mkDerivation (finalAttrs: {
 
   enableParallelBuilding = true;
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/atril.thumbnailer \
+      --replace-fail "TryExec=atril-thumbnailer" "TryExec=$out/bin/atril-thumbnailer" \
+      --replace-fail "Exec=atril-thumbnailer" "Exec=$out/bin/atril-thumbnailer"
+  '';
+
   passthru.updateScript = gitUpdater {
     rev-prefix = "v";
     odd-unstable = true;
diff --git a/pkgs/by-name/co/cosmic-player/package.nix b/pkgs/by-name/co/cosmic-player/package.nix
index 2984faa4d9db..030ff794d867 100644
--- a/pkgs/by-name/co/cosmic-player/package.nix
+++ b/pkgs/by-name/co/cosmic-player/package.nix
@@ -72,6 +72,10 @@ rustPlatform.buildRustPackage (finalAttrs: {
 
   preFixup = ''
     libcosmicAppWrapperArgs+=(--prefix GST_PLUGIN_SYSTEM_PATH_1_0 : "$GST_PLUGIN_SYSTEM_PATH_1_0")
+
+    substituteInPlace $out/share/thumbnailers/com.system76.CosmicPlayer.thumbnailer \
+      --replace-fail "TryExec=cosmic-player" "TryExec=$out/bin/cosmic-player" \
+      --replace-fail "Exec=cosmic-player" "Exec=$out/bin/cosmic-player"
   '';
 
   passthru = {
diff --git a/pkgs/by-name/co/cosmic-reader/package.nix b/pkgs/by-name/co/cosmic-reader/package.nix
index e9aaa8d7d4cc..f3aa6f97e8e5 100644
--- a/pkgs/by-name/co/cosmic-reader/package.nix
+++ b/pkgs/by-name/co/cosmic-reader/package.nix
@@ -66,6 +66,12 @@ rustPlatform.buildRustPackage (finalAttrs: {
     "target/${stdenv.hostPlatform.rust.cargoShortTarget}"
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/com.system76.CosmicReader.thumbnailer \
+      --replace-fail "TryExec=cosmic-reader" "TryExec=$out/bin/cosmic-reader" \
+      --replace-fail "Exec=cosmic-reader" "Exec=$out/bin/cosmic-reader"
+  '';
+
   passthru.updateScript = nix-update-script {
     extraArgs = [
       "--version"
diff --git a/pkgs/by-name/cr/crosswords/package.nix b/pkgs/by-name/cr/crosswords/package.nix
index 03caee7c28d5..a0f1538a6ac6 100644
--- a/pkgs/by-name/cr/crosswords/package.nix
+++ b/pkgs/by-name/cr/crosswords/package.nix
@@ -45,6 +45,12 @@ stdenv.mkDerivation (finalAttrs: {
     libipuz
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/crosswords.thumbnailer \
+      --replace-fail "TryExec=crosswords-thumbnailer" "TryExec=$out/bin/crosswords-thumbnailer" \
+      --replace-fail "Exec=crosswords-thumbnailer" "Exec=$out/bin/crosswords-thumbnailer"
+  '';
+
   passthru.updateScript = nix-update-script { };
 
   meta = {
diff --git a/pkgs/by-name/di/dia/package.nix b/pkgs/by-name/di/dia/package.nix
index 0f56413de916..c71a40831715 100644
--- a/pkgs/by-name/di/dia/package.nix
+++ b/pkgs/by-name/di/dia/package.nix
@@ -98,6 +98,12 @@ stdenv.mkDerivation {
     gtk-mac-integration-gtk3
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/org.gnome.Dia.thumbnailer \
+      --replace-fail "TryExec=dia" "TryExec=$out/bin/dia" \
+      --replace-fail "Exec=dia" "Exec=$out/bin/dia"
+  '';
+
   meta = {
     description = "Gnome Diagram drawing software";
     mainProgram = "dia";
diff --git a/pkgs/by-name/ev/evince/package.nix b/pkgs/by-name/ev/evince/package.nix
index 889ec7107238..f1f6e7c67a36 100644
--- a/pkgs/by-name/ev/evince/package.nix
+++ b/pkgs/by-name/ev/evince/package.nix
@@ -126,6 +126,12 @@ stdenv.mkDerivation (finalAttrs: {
     "-DHAVE_STDLIB_H"
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/evince.thumbnailer \
+      --replace-fail "TryExec=evince-thumbnailer" "TryExec=$out/bin/evince-thumbnailer" \
+      --replace-fail "Exec=evince-thumbnailer" "Exec=$out/bin/evince-thumbnailer"
+  '';
+
   preFixup = ''
     gappsWrapperArgs+=(--prefix XDG_DATA_DIRS : "${shared-mime-info}/share")
   '';
diff --git a/pkgs/by-name/f3/f3d/package.nix b/pkgs/by-name/f3/f3d/package.nix
index a88437a7e22a..6a9411366128 100644
--- a/pkgs/by-name/f3/f3d/package.nix
+++ b/pkgs/by-name/f3/f3d/package.nix
@@ -84,6 +84,14 @@ stdenv.mkDerivation rec {
     "-DF3D_PLUGIN_BUILD_USD=ON"
   ];
 
+  postInstall = ''
+    for thumbnailer in $out/share/thumbnailers/f3d-plugin-*.thumbnailer; do
+      substituteInPlace $thumbnailer \
+        --replace-fail "TryExec=f3d" "TryExec=$out/bin/f3d" \
+        --replace-fail "Exec=f3d" "Exec=$out/bin/f3d"
+    done
+  '';
+
   meta = {
     description = "Fast and minimalist 3D viewer using VTK";
     homepage = "https://f3d-app.github.io/f3d";
diff --git a/pkgs/by-name/fr/freecad/package.nix b/pkgs/by-name/fr/freecad/package.nix
index 9c8a86bad1c4..e187dddf8deb 100644
--- a/pkgs/by-name/fr/freecad/package.nix
+++ b/pkgs/by-name/fr/freecad/package.nix
@@ -138,6 +138,12 @@ freecad-utils.makeCustomizable (
         "--prefix PYTHONPATH : ${python3Packages.makePythonPath pythonDeps}"
       ];
 
+    postInstall = ''
+      substituteInPlace $out/share/thumbnailers/FreeCAD.thumbnailer \
+        --replace-fail "TryExec=freecad-thumbnailer" "TryExec=$out/bin/freecad-thumbnailer" \
+        --replace-fail "Exec=freecad-thumbnailer" "Exec=$out/bin/freecad-thumbnailer"
+    '';
+
     postFixup = ''
       mv $out/share/doc $out
       ln -s $out/doc $out/share/doc
diff --git a/pkgs/by-name/gl/glslviewer/package.nix b/pkgs/by-name/gl/glslviewer/package.nix
index 688e5b801971..a367e8b89296 100644
--- a/pkgs/by-name/gl/glslviewer/package.nix
+++ b/pkgs/by-name/gl/glslviewer/package.nix
@@ -43,6 +43,13 @@ stdenv.mkDerivation (finalAttrs: {
     ffmpeg_7
     python3
   ];
+
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/glslViewer.thumbnailer \
+      --replace-fail "TryExec=glslThumbnailer" "TryExec=$out/bin/glslThumbnailer" \
+      --replace-fail "Exec=glslThumbnailer" "Exec=$out/bin/glslThumbnailer"
+  '';
+
   meta = {
     description = "Live GLSL coding renderer";
     homepage = "https://patriciogonzalezvivo.com/2015/glslViewer/";
diff --git a/pkgs/by-name/gn/gnome-font-viewer/package.nix b/pkgs/by-name/gn/gnome-font-viewer/package.nix
index 979cee9c9aee..e3231f2d300d 100644
--- a/pkgs/by-name/gn/gnome-font-viewer/package.nix
+++ b/pkgs/by-name/gn/gnome-font-viewer/package.nix
@@ -47,6 +47,12 @@ stdenv.mkDerivation (finalAttrs: {
     fribidi
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/gnome-font-viewer.thumbnailer \
+      --replace-fail "TryExec=gnome-thumbnail-font" "TryExec=$out/bin/gnome-thumbnail-font" \
+      --replace-fail "Exec=gnome-thumbnail-font" "Exec=$out/bin/gnome-thumbnail-font"
+  '';
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = "gnome-font-viewer";
diff --git a/pkgs/by-name/ic/icoextract/package.nix b/pkgs/by-name/ic/icoextract/package.nix
index 76a7e0df1b04..0caa4544c881 100644
--- a/pkgs/by-name/ic/icoextract/package.nix
+++ b/pkgs/by-name/ic/icoextract/package.nix
@@ -30,6 +30,9 @@ python3Packages.buildPythonApplication (finalAttrs: {
 
   postInstall = ''
     install -Dm644 exe-thumbnailer.thumbnailer -t $out/share/thumbnailers
+
+    substituteInPlace $out/share/thumbnailers/exe-thumbnailer.thumbnailer \
+      --replace-fail "Exec=exe-thumbnailer" "Exec=$out/bin/exe-thumbnailer"
   '';
 
   meta = {
diff --git a/pkgs/by-name/li/libgsf/package.nix b/pkgs/by-name/li/libgsf/package.nix
index 56151be8ef97..c05c128e1aa8 100644
--- a/pkgs/by-name/li/libgsf/package.nix
+++ b/pkgs/by-name/li/libgsf/package.nix
@@ -83,6 +83,12 @@ stdenv.mkDerivation (finalAttrs: {
     patchShebangs ./tests/
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/gsf-office.thumbnailer \
+      --replace-fail "TryExec=gsf-office-thumbnailer" "TryExec=$out/bin/gsf-office-thumbnailer" \
+      --replace-fail "Exec=gsf-office-thumbnailer" "Exec=$out/bin/gsf-office-thumbnailer"
+  '';
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = finalAttrs.pname;
diff --git a/pkgs/by-name/li/libresprite/package.nix b/pkgs/by-name/li/libresprite/package.nix
index 630508099365..87df7ef2e689 100644
--- a/pkgs/by-name/li/libresprite/package.nix
+++ b/pkgs/by-name/li/libresprite/package.nix
@@ -87,6 +87,10 @@ stdenv.mkDerivation (finalAttrs: {
       dst="$out"/share/icons/hicolor/"$size"x"$size"
       install -Dm644 "$src"/doc"$size".png "$dst"/mimetypes/aseprite.png
     done
+
+    substituteInPlace $out/share/thumbnailers/libresprite.thumbnailer \
+      --replace-fail "TryExec=libresprite-thumbnailer" "TryExec=$out/bin/libresprite-thumbnailer" \
+      --replace-fail "Exec=libresprite-thumbnailer" "Exec=$out/bin/libresprite-thumbnailer"
   '';
 
   passthru.tests = {
diff --git a/pkgs/by-name/ma/mate-control-center/package.nix b/pkgs/by-name/ma/mate-control-center/package.nix
index 63374a83fe80..44036743da0b 100644
--- a/pkgs/by-name/ma/mate-control-center/package.nix
+++ b/pkgs/by-name/ma/mate-control-center/package.nix
@@ -89,6 +89,12 @@ stdenv.mkDerivation (finalAttrs: {
 
   configureFlags = [ "--disable-update-mimedb" ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/mate-font-viewer.thumbnailer \
+      --replace-fail "TryExec=mate-thumbnail-font" "TryExec=$out/bin/mate-thumbnail-font" \
+      --replace-fail "Exec=mate-thumbnail-font" "Exec=$out/bin/mate-thumbnail-font"
+  '';
+
   preFixup = ''
     gappsWrapperArgs+=(
       # WM keyboard shortcuts
diff --git a/pkgs/by-name/my/mypaint/package.nix b/pkgs/by-name/my/mypaint/package.nix
index 1cc8964da495..c8694de75e96 100644
--- a/pkgs/by-name/my/mypaint/package.nix
+++ b/pkgs/by-name/my/mypaint/package.nix
@@ -161,6 +161,12 @@ buildPythonApplication (finalAttrs: {
     runHook postCheck
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/mypaint-ora.thumbnailer \
+      --replace-fail "TryExec=mypaint-ora-thumbnailer" "TryExec=$out/bin/mypaint-ora-thumbnailer" \
+      --replace-fail "Exec=mypaint-ora-thumbnailer" "Exec=$out/bin/mypaint-ora-thumbnailer"
+  '';
+
   meta = {
     description = "Graphics application for digital painters";
     homepage = "http://mypaint.org/";
diff --git a/pkgs/by-name/re/renderdoc/package.nix b/pkgs/by-name/re/renderdoc/package.nix
index 7d9436496311..12912b92fcaa 100644
--- a/pkgs/by-name/re/renderdoc/package.nix
+++ b/pkgs/by-name/re/renderdoc/package.nix
@@ -142,6 +142,12 @@ stdenv.mkDerivation (finalAttrs: {
      )
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/renderdoc.thumbnailer \
+      --replace-fail "TryExec=/usr/bin/renderdoccmd" "TryExec=$out/bin/renderdoccmd" \
+      --replace-fail "Exec=/usr/bin/renderdoccmd" "Exec=$out/bin/renderdoccmd"
+  '';
+
   preFixup =
     let
       libPath = lib.makeLibraryPath [
diff --git a/pkgs/by-name/rn/rnote/package.nix b/pkgs/by-name/rn/rnote/package.nix
index 33ec119668be..6c16651eea0d 100644
--- a/pkgs/by-name/rn/rnote/package.nix
+++ b/pkgs/by-name/rn/rnote/package.nix
@@ -80,6 +80,12 @@ stdenv.mkDerivation (finalAttrs: {
     patchShebangs build-aux
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/rnote.thumbnailer \
+      --replace-fail "TryExec=rnote-cli" "TryExec=$out/bin/rnote-cli" \
+      --replace-fail "Exec=rnote-cli" "Exec=$out/bin/rnote-cli"
+  '';
+
   env = lib.optionalAttrs stdenv.cc.isClang {
     NIX_CFLAGS_COMPILE = "-Wno-error=incompatible-function-pointer-types";
   };
diff --git a/pkgs/by-name/sa/sameboy/package.nix b/pkgs/by-name/sa/sameboy/package.nix
index 680e0b6ecc61..c6070d15d3c8 100644
--- a/pkgs/by-name/sa/sameboy/package.nix
+++ b/pkgs/by-name/sa/sameboy/package.nix
@@ -48,6 +48,12 @@ stdenv.mkDerivation (finalAttrs: {
       --replace-fail '"libgtk-3.so"' '"${gtk3}/lib/libgtk-3.so"'
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/sameboy.thumbnailer \
+      --replace-fail "TryExec=sameboy-thumbnailer" "TryExec=$out/bin/sameboy-thumbnailer" \
+      --replace-fail "Exec=sameboy-thumbnailer" "Exec=$out/bin/sameboy-thumbnailer"
+  '';
+
   meta = {
     homepage = "https://sameboy.github.io";
     description = "Game Boy, Game Boy Color, and Super Game Boy emulator";
diff --git a/pkgs/by-name/ti/tiled/package.nix b/pkgs/by-name/ti/tiled/package.nix
index d08ea9231d97..2eb9fd58db59 100644
--- a/pkgs/by-name/ti/tiled/package.nix
+++ b/pkgs/by-name/ti/tiled/package.nix
@@ -76,6 +76,12 @@ stdenv.mkDerivation (finalAttrs: {
     runHook postInstall
   '';
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/tiled.thumbnailer \
+      --replace-fail "TryExec=tmxrasterizer" "TryExec=$out/bin/tmxrasterizer" \
+      --replace-fail "Exec=tmxrasterizer" "Exec=$out/bin/tmxrasterizer"
+  '';
+
   meta = {
     description = "Free, easy to use and flexible tile map editor";
     homepage = "https://www.mapeditor.org/";
diff --git a/pkgs/by-name/xo/xournalpp/package.nix b/pkgs/by-name/xo/xournalpp/package.nix
index 3de0a9384c01..4df6311020bc 100644
--- a/pkgs/by-name/xo/xournalpp/package.nix
+++ b/pkgs/by-name/xo/xournalpp/package.nix
@@ -67,6 +67,11 @@ stdenv.mkDerivation (finalAttrs: {
 
   buildFlags = [ "translations" ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/com.github.xournalpp.xournalpp.thumbnailer \
+      --replace-fail "Exec=xournalpp-thumbnailer" "Exec=$out/bin/xournalpp-thumbnailer"
+  '';
+
   preFixup = ''
     gappsWrapperArgs+=(
       --prefix XDG_DATA_DIRS : "${adwaita-icon-theme}/share"
diff --git a/pkgs/by-name/xr/xreader/package.nix b/pkgs/by-name/xr/xreader/package.nix
index fdcde558a6fa..e47ecd43217d 100644
--- a/pkgs/by-name/xr/xreader/package.nix
+++ b/pkgs/by-name/xr/xreader/package.nix
@@ -79,6 +79,12 @@ stdenv.mkDerivation (finalAttrs: {
     djvulibre
   ];
 
+  postInstall = ''
+    substituteInPlace $out/share/thumbnailers/xreader.thumbnailer \
+      --replace-fail "TryExec=xreader-thumbnailer" "TryExec=$out/bin/xreader-thumbnailer" \
+      --replace-fail "Exec=xreader-thumbnailer" "Exec=$out/bin/xreader-thumbnailer"
+  '';
+
   preFixup = ''
     gappsWrapperArgs+=(
       --prefix XDG_DATA_DIRS : "${lib.makeSearchPath "share" [ xapp-symbolic-icons ]}"