diff --git a/pkgs/os-specific/linux/kernel/common-config.nix b/pkgs/os-specific/linux/kernel/common-config.nix
index 42653d4ef3b3..2a396189558d 100644
--- a/pkgs/os-specific/linux/kernel/common-config.nix
+++ b/pkgs/os-specific/linux/kernel/common-config.nix
@@ -1102,7 +1102,10 @@ let
 
         # enable support for device trees and overlays
         OF = option yes;
-        OF_OVERLAY = option yes;
+        # OF_OVERLAY breaks v5.10 on x86_64, see https://github.com/NixOS/nixpkgs/issues/403985
+        OF_OVERLAY = lib.mkIf (!(lib.versionOlder version "5.15" && stdenv.hostPlatform.isx86_64)) (
+          option yes
+        );
 
         # Enable initrd support.
         BLK_DEV_INITRD = yes;