diff --git a/pkgs/development/ocaml-modules/reason-react/default.nix b/pkgs/development/ocaml-modules/reason-react/default.nix
index a447c3172d60..d8defe1697bd 100644
--- a/pkgs/development/ocaml-modules/reason-react/default.nix
+++ b/pkgs/development/ocaml-modules/reason-react/default.nix
@@ -1,5 +1,6 @@
 {
   buildDunePackage,
+  fetchpatch,
   melange,
   reason,
   reason-react-ppx,
@@ -8,6 +9,14 @@
 buildDunePackage {
   pname = "reason-react";
   inherit (reason-react-ppx) version src;
+  patches = [
+    # Makes tests compatible with melange 5.0.0
+    (fetchpatch {
+      url = "https://github.com/reasonml/reason-react/commit/661e93553ae48af410895477c339be4f0a203437.patch";
+      includes = [ "test/*" ];
+      hash = "sha256-khxPxC/GpByjcEZDoQ1NdXoM/yQBAKmnUnt/d2k6WfQ=";
+    })
+  ];
   nativeBuildInputs = [
     reason
     melange
diff --git a/pkgs/development/tools/ocaml/melange/default.nix b/pkgs/development/tools/ocaml/melange/default.nix
index 98f503d2e13e..4e4401fe7681 100644
--- a/pkgs/development/tools/ocaml/melange/default.nix
+++ b/pkgs/development/tools/ocaml/melange/default.nix
@@ -21,22 +21,27 @@
 let
   pname = "melange";
   versionHash =
-    if lib.versionAtLeast ocaml.version "5.2" then
+    if lib.versionAtLeast ocaml.version "5.3" then
       {
-        version = "4.0.1-52";
-        hash = "sha256-kUlChqQtLX7zh90GK23ibMqyI/MIp0sMYLjkPX9vdTc=";
+        version = "5.0.0-53";
+        hash = "sha256-ZZ3/TdhEJQ74Q3wJkWqoiONEfV6x77z0Sbr8cAirXbA=";
+      }
+    else if lib.versionAtLeast ocaml.version "5.2" then
+      {
+        version = "5.0.0-52";
+        hash = "sha256-DyjBiMvnCHufFepk8xHMMmVU+j/yECvV7My4WeAW4WQ=";
       }
     else if lib.versionAtLeast ocaml.version "5.1" then
       {
-        version = "4.0.0-51";
-        hash = "sha256-940Yzp1ZXnN6mKVWY+nqKjn4qtBUJR5eHE55OTjGvdU=";
+        version = "5.0.0-51";
+        hash = "sha256-rPU6pqzEDo5heGkHhMGfwsF8elDohoptNbbZyGcWLKA=";
       }
     else if lib.versionAtLeast ocaml.version "5.0" then
       throw "melange is not available for OCaml ${ocaml.version}"
     else
       {
-        version = "4.0.0-414";
-        hash = "sha256-PILDOXYIyLvfv1sSwP6WSdCiXfpYdnct7WMw3jHBLJM=";
+        version = "5.0.0-414";
+        hash = "sha256-07+tEx6b5dUY949VF2K22HqRSoKmvBwnxo7B/Gqb+ro=";
       };
   version = versionHash.version;
   hash = versionHash.hash;