diff --git a/pkgs/development/libraries/libvirt/default.nix b/pkgs/development/libraries/libvirt/default.nix
index c36e3116dad6..4c3740e4ba7c 100644
--- a/pkgs/development/libraries/libvirt/default.nix
+++ b/pkgs/development/libraries/libvirt/default.nix
@@ -155,16 +155,12 @@ stdenv.mkDerivation rec {
       src/storage/storage_backend_disk.c \
       src/storage/storage_util.c
   '' + lib.optionalString isDarwin ''
-    sed -i '/qemucapabilitiestest/d' tests/meson.build
-    sed -i '/vircryptotest/d' tests/meson.build
-    sed -i '/domaincapstest/d' tests/meson.build
+    # Darwin doesn’t support -fsemantic-interposition, but the problem doesn’t seem to affect Mach-O.
+    # See https://gitlab.com/libvirt/libvirt/-/merge_requests/235
+    sed -i "s/not supported_cc_flags.contains('-fsemantic-interposition')/false/" meson.build
     sed -i '/qemufirmwaretest/d' tests/meson.build
     sed -i '/qemuvhostusertest/d' tests/meson.build
     sed -i '/qemuxml2xmltest/d' tests/meson.build
-  '' + lib.optionalString (isDarwin && isx86_64) ''
-    sed -i '/qemucaps2xmltest/d' tests/meson.build
-    sed -i '/qemuhotplugtest/d' tests/meson.build
-    sed -i '/virnetdaemontest/d' tests/meson.build
   '';
 
   strictDeps = true;