diff --git a/pkgs/development/python-modules/mozjpeg_lossless_optimization/default.nix b/pkgs/development/python-modules/mozjpeg_lossless_optimization/default.nix
new file mode 100644
index 000000000000..431e6ce15cf9
--- /dev/null
+++ b/pkgs/development/python-modules/mozjpeg_lossless_optimization/default.nix
@@ -0,0 +1,53 @@
+{
+  lib,
+  python3Packages,
+  fetchFromGitHub,
+  buildPythonPackage,
+  mozjpeg,
+  pytestCheckHook,
+  setuptools,
+  cmake,
+  nix-update-script,
+  cffi,
+}:
+buildPythonPackage rec {
+  pname = "mozjpeg_lossless_optimization";
+  version = "1.1.3";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "wanadev";
+    repo = "mozjpeg-lossless-optimization";
+    # https://github.com/NixOS/nixpkgs/issues/26302
+    rev = "refs/tags/v${version}";
+    hash = "sha256-OKNt9XtfZ6hhRJN1Asn1T2dVjyXKQAsnFvXKYnrRZ98=";
+    fetchSubmodules = true;
+  };
+
+  # This package needs cmake, but it is not the default builder
+  dontUseCmakeConfigure = true;
+
+  buildInputs = [ mozjpeg ];
+  nativeBuildInputs = [ cmake ];
+  propagatedBuildInputs = [ cffi ];
+
+  # https://github.com/NixOS/nixpkgs/issues/255262
+  preCheck = ''
+    rm -r mozjpeg_lossless_optimization
+  '';
+
+  build-system = [ setuptools ];
+  nativeCheckInputs = [ pytestCheckHook ];
+
+  passthru = {
+    updateScript = nix-update-script { };
+  };
+
+  meta = {
+    description = "Python library to optimize JPEGs losslessly using MozJPEG";
+    homepage = "https://github.com/wanadev/mozjpeg-lossless-optimization";
+    changelog = "https://github.com/wanadev/mozjpeg-lossless-optimization/releases/tag/v${version}";
+    license = lib.licenses.bsd3;
+    maintainers = [ lib.maintainers.adfaure ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index d81ba7424d74..58f0387ad3ab 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -9154,6 +9154,10 @@ self: super: with self; {
 
   mozilla-django-oidc = callPackage ../development/python-modules/mozilla-django-oidc { };
 
+  mozjpeg_lossless_optimization =
+    callPackage ../development/python-modules/mozjpeg_lossless_optimization
+      { };
+
   mpd2 = callPackage ../development/python-modules/mpd2 { };
 
   mpegdash = callPackage ../development/python-modules/mpegdash { };