diff --git a/pkgs/development/python-modules/pyblake2/default.nix b/pkgs/development/python-modules/pyblake2/default.nix
deleted file mode 100644
index a0f62cf0e77f..000000000000
--- a/pkgs/development/python-modules/pyblake2/default.nix
+++ /dev/null
@@ -1,23 +0,0 @@
-{ lib
-, buildPythonPackage
-, fetchPypi
-}:
-
-buildPythonPackage rec {
-  pname = "pyblake2";
-  version = "1.1.2";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "5ccc7eb02edb82fafb8adbb90746af71460fbc29aa0f822526fc976dff83e93f";
-  };
-
-  # requires setting up sphinx doctest
-  doCheck = false;
-
-  meta = {
-    description = "BLAKE2 hash function extension module";
-    license = lib.licenses.publicDomain;
-    homepage = "https://github.com/dchest/pyblake2";
-  };
-}
diff --git a/pkgs/development/python-modules/trezor/default.nix b/pkgs/development/python-modules/trezor/default.nix
index a106db6d5656..24c282d7d8b1 100644
--- a/pkgs/development/python-modules/trezor/default.nix
+++ b/pkgs/development/python-modules/trezor/default.nix
@@ -14,7 +14,6 @@
 , mnemonic
 , pillow
 , protobuf
-, pyblake2
 , requests
 , shamir-mnemonic
 , simple-rlp
@@ -47,7 +46,6 @@ buildPythonPackage rec {
     mnemonic
     pillow
     protobuf
-    pyblake2
     requests
     shamir-mnemonic
     simple-rlp
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 7af70d4884f4..e0fb03cbca0d 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -186,6 +186,7 @@ mapAliases ({
   pushbullet = pushbullet-py;  # Added 2022-10-15
   Pweave = pweave; # added 2023-02-19
   pyalmond = throw "pyalmond has been removed, since its API endpoints have been shutdown"; # added 2023-02-02
+  pyblake2 = throw "pyblake2 is deprecated in favor of hashlib"; # added 2023-04-23
   pydrive = throw "pydrive is broken and deprecated and has been replaced with pydrive2."; # added 2022-06-01
   PyGithub = pygithub; # added 2023-02-19
   pyGtkGlade = throw "Glade support for pygtk has been removed"; # added 2022-01-15
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f6af5c709edb..a8e15ce0d1e0 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8016,8 +8016,6 @@ self: super: with self; {
 
   pyblackbird = callPackage ../development/python-modules/pyblackbird { };
 
-  pyblake2 = callPackage ../development/python-modules/pyblake2 { };
-
   pyblock = toPythonModule (callPackage ../development/python-modules/pyblock { });
 
   pybluez = callPackage ../development/python-modules/pybluez {