diff --git a/pkgs/development/python-modules/astropy/default.nix b/pkgs/development/python-modules/astropy/default.nix
index 4e26f583b2f9..ef024251b855 100644
--- a/pkgs/development/python-modules/astropy/default.nix
+++ b/pkgs/development/python-modules/astropy/default.nix
@@ -62,6 +62,10 @@ buildPythonPackage rec {
     hash = "sha256-6S18n+6G6z34cU5d1Bu/nxY9ND4aGD2Vv2vQnkMTyUA=";
   };
 
+  env = lib.optionalAttrs stdenv.cc.isClang {
+    NIX_CFLAGS_COMPILE = "-Wno-error=unused-command-line-argument";
+  };
+
   build-system = [
     cython
     extension-helpers