diff --git a/pkgs/development/python-modules/tuf/default.nix b/pkgs/development/python-modules/tuf/default.nix
new file mode 100644
index 000000000000..b6965a7f42e2
--- /dev/null
+++ b/pkgs/development/python-modules/tuf/default.nix
@@ -0,0 +1,61 @@
+{ lib
+, buildPythonPackage
+, ed25519
+, fetchFromGitHub
+, hatchling
+, pytestCheckHook
+, pythonOlder
+, requests
+, securesystemslib
+}:
+
+buildPythonPackage rec {
+  pname = "tuf";
+  version = "3.1.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "theupdateframework";
+    repo = "python-tuf";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-IGF/8RdX7Oxl6gdqPGN1w/6q4zaei+MnYXBZepB4KUA=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace "hatchling==" "hatchling>="
+  '';
+
+  nativeBuildInputs = [
+    hatchling
+  ];
+
+  propagatedBuildInputs = [
+    requests
+    securesystemslib
+  ] ++ securesystemslib.optional-dependencies.pynacl
+  ++ securesystemslib.optional-dependencies.crypto;
+
+  nativeCheckInputs = [
+    ed25519
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "tuf"
+  ];
+
+  preCheck = ''
+    cd tests
+  '';
+
+  meta = with lib; {
+    description = "Python reference implementation of The Update Framework (TUF)";
+    homepage = "https://github.com/theupdateframework/python-tuf";
+    changelog = "https://github.com/theupdateframework/python-tuf/blob/v${version}/docs/CHANGELOG.md";
+    license = with licenses; [ asl20 mit ];
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index a822afe36f27..ad94a450060a 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -14327,6 +14327,8 @@ self: super: with self; {
 
   tubes = callPackage ../development/python-modules/tubes { };
 
+  tuf = callPackage ../development/python-modules/tuf { };
+
   tunigo = callPackage ../development/python-modules/tunigo { };
 
   tubeup = callPackage ../development/python-modules/tubeup { };