diff --git a/pkgs/development/python-modules/mhcgnomes/default.nix b/pkgs/development/python-modules/mhcgnomes/default.nix
index b5a1660e5774..f963f94a3b56 100644
--- a/pkgs/development/python-modules/mhcgnomes/default.nix
+++ b/pkgs/development/python-modules/mhcgnomes/default.nix
@@ -1,38 +1,52 @@
 {
+  lib,
   buildPythonPackage,
   fetchFromGitHub,
-  lib,
+
+  # build-system
+  setuptools,
+
+  # dependencies
   pandas,
   pyyaml,
-  serializable,
+  numpy,
+
+  # tests
+  pytestCheckHook,
 }:
 
-buildPythonPackage {
+buildPythonPackage (finalAttrs: {
   pname = "mhcgnomes";
-  version = "1.8.6";
-  format = "setuptools";
+  version = "3.15.1";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "pirl-unc";
     repo = "mhcgnomes";
-    # See https://github.com/pirl-unc/mhcgnomes/issues/20. As of 2023-07-13,
-    # they do no have version tags.
-    rev = "c7e779b60e35a031f6e0f0ea6ae70e8a8e7671c6";
-    hash = "sha256-KKiBlnFlavRnaQnOpAzG0dyxmFB+zF9L6t/H05LkFZE=";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-tcJfGIJsbCdN+U/+2zsYBhKEJNy55QMf7eu9Z4nuXlk=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
     pandas
     pyyaml
-    serializable
+    numpy
   ];
 
   pythonImportsCheck = [ "mhcgnomes" ];
 
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
   meta = {
     description = "Parsing MHC nomenclature in the wild";
     homepage = "https://github.com/pirl-unc/mhcgnomes";
     license = lib.licenses.asl20;
     maintainers = with lib.maintainers; [ samuela ];
   };
-}
+})