diff --git a/pkgs/development/python-modules/vispy/default.nix b/pkgs/development/python-modules/vispy/default.nix
index 36833c75ff48..d3597727926a 100644
--- a/pkgs/development/python-modules/vispy/default.nix
+++ b/pkgs/development/python-modules/vispy/default.nix
@@ -31,7 +31,7 @@ buildPythonPackage rec {
     hash = "sha256-7ti0TW9ch70pWySqmi4OTm3GqQXM7gGy1ByPvwp2ez0=";
   };
 
-  patches = [
+  patches = lib.optionals (!stdenv.hostPlatform.isDarwin) [
     (substituteAll {
       src = ./library-paths.patch;
       fontconfig = "${fontconfig.lib}/lib/libfontconfig${stdenv.hostPlatform.extensions.sharedLibrary}";