diff --git a/pkgs/applications/emulators/epsxe/default.nix b/pkgs/applications/emulators/epsxe/default.nix
deleted file mode 100644
index f39c2ae74ac4..000000000000
--- a/pkgs/applications/emulators/epsxe/default.nix
+++ /dev/null
@@ -1,52 +0,0 @@
-{ lib, stdenv, fetchurl, alsa-lib, curl, gdk-pixbuf, glib, gtk3, libGLU, libGL,
-  libX11, openssl_1_0_2, ncurses5, SDL, SDL_ttf, unzip, zlib, wrapGAppsHook, autoPatchelfHook }:
-
-with lib;
-
-stdenv.mkDerivation rec {
-  pname = "epsxe";
-  version = "2.0.5";
-
-  src = let
-    version2 = replaceStrings ["."] [""] version;
-    platform = "linux" + (optionalString stdenv.is64bit "_x64");
-  in fetchurl {
-    url = "https://www.epsxe.com/files/ePSXe${version2}${platform}.zip";
-    sha256 = if stdenv.is64bit
-             then "16fa9qc2xhaz1f6294m0b56s5l86cbmclwm9w3mqnch0yjsrvab0"
-             else "1677lclam557kp8jwvchdrk27zfj50fqx2q9i3bcx26d9k61q3kl";
-  };
-
-  nativeBuildInputs = [ unzip wrapGAppsHook autoPatchelfHook ];
-  sourceRoot = ".";
-
-  buildInputs = [
-    alsa-lib
-    curl
-    gdk-pixbuf
-    glib
-    gtk3
-    libX11
-    libGLU libGL
-    openssl_1_0_2
-    ncurses5
-    SDL
-    SDL_ttf
-    stdenv.cc.cc.lib
-    zlib
-  ];
-
-  dontStrip = true;
-
-  installPhase = ''
-    install -D ${if stdenv.is64bit then "epsxe_x64" else "ePSXe"} $out/bin/epsxe
-  '';
-
-  meta = {
-    homepage = "http://epsxe.com/";
-    description = "Enhanced PSX (PlayStation 1) emulator";
-    license = licenses.unfree;
-    maintainers = with maintainers; [ yana ];
-    platforms = [ "i686-linux" "x86_64-linux" ];
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 191344cbd989..54a278d58d41 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -309,6 +309,7 @@ mapAliases ({
   encryptr = throw "encryptr was removed because it reached end of life"; # Added 2022-02-06
   envelope = throw "envelope has been removed from nixpkgs, as it was unmaintained"; # Added 2021-08-05
   epoxy = libepoxy; # Added 2021-11-11
+  epsxe = throw "epsxe has been removed from nixpkgs, as it was unmaintained."; # added 2021-12-15
   esniper = throw "esniper has been removed because upstream no longer maintains it (and it no longer works)"; # Added 2021-04-12
   etcdctl = throw "'etcdctl' has been renamed to/replaced by 'etcd'"; # Converted to throw 2022-02-22
   eteroj.lv2 = throw "'eteroj.lv2' has been renamed to/replaced by 'open-music-kontrollers.eteroj'"; # Added 2022-03-09
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 0cf4ba89639b..370b6a9a7f92 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -5316,8 +5316,6 @@ with pkgs;
 
   epstool = callPackage ../tools/graphics/epstool { };
 
-  epsxe = callPackage ../applications/emulators/epsxe { };
-
   escrotum = callPackage ../tools/graphics/escrotum { };
 
   etcher = callPackage ../tools/misc/etcher {