diff --git a/pkgs/development/python-modules/pyfaidx/default.nix b/pkgs/development/python-modules/pyfaidx/default.nix
index a50c8accb858..a2815c3e1e2d 100644
--- a/pkgs/development/python-modules/pyfaidx/default.nix
+++ b/pkgs/development/python-modules/pyfaidx/default.nix
@@ -1,24 +1,52 @@
 { lib
 , buildPythonPackage
 , fetchPypi
+, nose
+, numpy
+, setuptools-scm
 , six
+, pytestCheckHook
 }:
 
 buildPythonPackage rec {
   pname = "pyfaidx";
   version = "0.6.3.1";
+  format = "setuptools";
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "93adf036a75e08dc9b1dcd59de6a4db2f65a48c603edabe2e499764b6535ed50";
   };
 
-  propagatedBuildInputs = [ six ];
+  nativeBuildInputs = [
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    six
+  ];
+
+  checkInputs = [
+    nose
+    numpy
+    pytestCheckHook
+  ];
+
+  disabledTests = [
+    # PyPI releases don't ship all the needed files for the tests
+    "test_index_zero_length"
+    "test_fetch_zero_length"
+    "test_read_back_index"
+  ];
+
+  pythonImportsCheck = [
+    "pyfaidx"
+  ];
 
   meta = with lib; {
     homepage = "https://github.com/mdshw5/pyfaidx";
     description = "Python classes for indexing, retrieval, and in-place modification of FASTA files using a samtools compatible index";
     license = licenses.bsd3;
-    maintainers = [ maintainers.jbedo ];
+    maintainers = with maintainers; [ jbedo ];
   };
 }