diff --git a/pkgs/build-support/build-setupcfg/default.nix b/pkgs/build-support/build-setupcfg/default.nix
deleted file mode 100644
index 5737989249af..000000000000
--- a/pkgs/build-support/build-setupcfg/default.nix
+++ /dev/null
@@ -1,26 +0,0 @@
-# Build a python package from info made available by setupcfg2nix.
-#
-# * src: The source of the package.
-# * info: The package information generated by setupcfg2nix.
-# * meta: Standard nixpkgs metadata.
-# * application: Whether this package is a python library or an
-#   application which happens to be written in python.
-# * doCheck: Whether to run the test suites.
-lib: pythonPackages:
-{ src, info, meta ? {}, application ? false, doCheck ? true}: let
-  build = if application
-    then pythonPackages.buildPythonApplication
-  else pythonPackages.buildPythonPackage;
-in build {
-  inherit (info) pname version;
-
-  inherit src meta doCheck;
-
-  nativeBuildInputs = map (p: pythonPackages.${p}) (
-    (info.setup_requires or []) ++
-    (lib.optionals doCheck (info.tests_require or []))
-  );
-
-  propagatedBuildInputs = map (p: pythonPackages.${p})
-    (info.install_requires or []);
-}
diff --git a/pkgs/development/interpreters/python/python-packages-base.nix b/pkgs/development/interpreters/python/python-packages-base.nix
index b5afaf34ce61..2126b796ca9d 100644
--- a/pkgs/development/interpreters/python/python-packages-base.nix
+++ b/pkgs/development/interpreters/python/python-packages-base.nix
@@ -47,9 +47,6 @@ let
     toPythonModule = x: x;  # Application does not provide modules.
   }));
 
-  # See build-setupcfg/default.nix for documentation.
-  buildSetupcfg = import ../../../build-support/build-setupcfg lib self;
-
   # Check whether a derivation provides a Python module.
   hasPythonModule = drv: drv?pythonModule && drv.pythonModule == python;
 
@@ -92,13 +89,11 @@ let
   disabledIf = x: drv: if x then disabled drv else drv;
 
 in {
-
   inherit lib pkgs stdenv;
   inherit (python.passthru) isPy27 isPy37 isPy38 isPy39 isPy310 isPy311 isPy3k isPyPy pythonAtLeast pythonOlder;
   inherit buildPythonPackage buildPythonApplication;
   inherit hasPythonModule requiredPythonModules makePythonPath disabled disabledIf;
   inherit toPythonModule toPythonApplication;
-  inherit buildSetupcfg;
 
   python = toPythonModule python;
   # Dont take pythonPackages from "global" pkgs scope to avoid mixing python versions
diff --git a/pkgs/development/tools/setupcfg2nix/default.nix b/pkgs/development/tools/setupcfg2nix/default.nix
deleted file mode 100644
index 4cc1ec320ccd..000000000000
--- a/pkgs/development/tools/setupcfg2nix/default.nix
+++ /dev/null
@@ -1,19 +0,0 @@
-{ buildSetupcfg, fetchFromGitHub, lib }:
-
-buildSetupcfg rec {
-  info = import ./info.nix;
-  src = fetchFromGitHub {
-    owner = "target";
-    repo = "setupcfg2nix";
-    rev = info.version;
-    sha256 = "1rj227vxybwp9acwnpwg9np964b1qcw2av3qmx00isnrw5vcps8m";
-  };
-  application = true;
-  meta = {
-    description = "Generate nix expressions from setup.cfg for a python package";
-    homepage = "https://github.com/target/setupcfg2nix";
-    license = lib.licenses.mit;
-    platforms = lib.platforms.all;
-    maintainers = [ lib.maintainers.shlevy ];
-  };
-}
diff --git a/pkgs/development/tools/setupcfg2nix/info.nix b/pkgs/development/tools/setupcfg2nix/info.nix
deleted file mode 100644
index 17e888fee416..000000000000
--- a/pkgs/development/tools/setupcfg2nix/info.nix
+++ /dev/null
@@ -1,7 +0,0 @@
-{
-  pname = "setupcfg2nix";
-  version = "2.0.1";
-  install_requires = [
-    "setuptools"
-  ];
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 9466a2c52587..016c8a655020 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -859,6 +859,7 @@ mapAliases ({
   sdlmame = throw "'sdlmame' has been renamed to/replaced by 'mame'"; # Converted to throw 2023-09-10
   searx = throw "'searx' has been removed as it is unmaintained. Please switch to searxng"; # Added 2023-10-03
   session-desktop-appimage = session-desktop;
+  setupcfg2nix = throw "'setupcfg2nix' has been removed. Please switch to buildPythonPackage"; # Added 2023-12-12
   sequoia = sequoia-sq; # Added 2023-06-26
   sexp = sexpp; # Added 2023-07-03
   sget = throw "sget has been removed from nixpkgs, as it is not supported upstream anymore see https://github.com/sigstore/sget/issues/145"; # Added 2023-05-26
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index e16f4773a96d..9358a77f80b5 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -17934,8 +17934,6 @@ with pkgs;
 
   pypi-mirror = callPackage ../development/tools/pypi-mirror { };
 
-  setupcfg2nix = python3Packages.callPackage ../development/tools/setupcfg2nix { };
-
   svg2tikz = with python3.pkgs; toPythonApplication svg2tikz;
 
   svg2pdf = callPackage ../tools/graphics/svg2pdf { };