diff --git a/pkgs/development/compilers/sbcl/default.nix b/pkgs/development/compilers/sbcl/default.nix
index 943c9ca627e2..5befbd94b476 100644
--- a/pkgs/development/compilers/sbcl/default.nix
+++ b/pkgs/development/compilers/sbcl/default.nix
@@ -152,6 +152,23 @@ stdenv.mkDerivation (self: {
       # Fail intermittently
       "gc.impure.lisp"
       "threads.pure.lisp"
+    ]
+    ++ lib.optionals (stdenv.hostPlatform.isDarwin) [
+      # This test has a gotcha on Darwin which originally showed up in
+      # 57b36ea5c83a1841b174ec6cd5e423439fe9d7a0, and later again around Oct
+      # 2025 in staging.  The test wants a clean environment (using
+      # run-program, akin to fork & execve), but darwin keeps injecting this
+      # envvar:
+      #
+      #   __CF_USER_TEXT_ENCODING=0x15F:0:0
+      #
+      # It’s not clear to maintainers where the problem lies exactly, but
+      # removing the test at least fixes the build and unblocks others.
+      #
+      # see:
+      # - https://github.com/NixOS/nixpkgs/pull/359214
+      # - https://github.com/NixOS/nixpkgs/pull/453099
+      "run-program.test.sh"
     ];
 
   patches =