diff --git a/pkgs/by-name/re/retool/package.nix b/pkgs/by-name/re/retool/package.nix
index 664862da8380..41fbdafbb80b 100644
--- a/pkgs/by-name/re/retool/package.nix
+++ b/pkgs/by-name/re/retool/package.nix
@@ -8,18 +8,34 @@
 
 python3.pkgs.buildPythonApplication (finalAttrs: {
   pname = "retool";
-  version = "2.4.5";
+  version = "2.4.8";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "unexpectedpanda";
     repo = "retool";
     tag = "v${finalAttrs.version}";
-    hash = "sha256-q1v/VPcKIMGcAtnELKUpVgRGPyMmL8zJr5RdOClCwoc=";
+    hash = "sha256-SSSHYwQtDtCONvM5Ze3G5JJ4TW5aCziS3EbxhliXx+g=";
   };
 
   pythonRelaxDeps = true;
 
+  postPatch = ''
+    # Upstream uses hatch-pyinstaller for a separate frozen-app target, but nixpkgs
+    # only builds the wheel. Keeping it in build-system.requires makes the wheel build
+    # fail unless the optional plugin is packaged too.
+    substituteInPlace pyproject.toml \
+      --replace-fail '"hatch-pyinstaller",' ""
+
+    # Retool derives its config/download directory from sys.argv[0], which points
+    # into the immutable Nix store. Redirect its mutable state to RETOOL_HOME or
+    # the current working directory instead.
+    substituteInPlace modules/config/config.py \
+      --replace-fail \
+        "self.retool_location: pathlib.Path = pathlib.Path(sys.argv[0]).resolve().parent" \
+        "self.retool_location: pathlib.Path = pathlib.Path(os.environ.get('RETOOL_HOME', pathlib.Path.cwd())).expanduser()"
+  '';
+
   build-system = with python3.pkgs; [ hatchling ];
 
   nativeBuildInputs = [ qt6.wrapQtAppsHook ];