diff --git a/pkgs/development/interpreters/guile/2.2.nix b/pkgs/development/interpreters/guile/2.2.nix
index 918735517ea3..617658e748b9 100644
--- a/pkgs/development/interpreters/guile/2.2.nix
+++ b/pkgs/development/interpreters/guile/2.2.nix
@@ -34,9 +34,9 @@ builder rec {
   outputs = [ "out" "dev" "info" ];
   setOutputFlags = false; # $dev gets into the library otherwise
 
-  depsBuildBuild = [
-    buildPackages.stdenv.cc
-  ]
+  depsBuildBuild = if stdenv.buildPlatform.isDarwin
+    then [ buildPackages.darwin.apple_sdk_11_0.stdenv.cc ]
+    else [ buildPackages.stdenv.cc ]
   ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform)
     pkgsBuildBuild.guile_2_2;
   nativeBuildInputs = [
diff --git a/pkgs/development/interpreters/guile/3.0.nix b/pkgs/development/interpreters/guile/3.0.nix
index 0708fb3d2974..ff27b01aad7c 100644
--- a/pkgs/development/interpreters/guile/3.0.nix
+++ b/pkgs/development/interpreters/guile/3.0.nix
@@ -35,9 +35,10 @@ builder rec {
   outputs = [ "out" "dev" "info" ];
   setOutputFlags = false; # $dev gets into the library otherwise
 
-  depsBuildBuild = [
-    buildPackages.stdenv.cc
-  ] ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform)
+  depsBuildBuild = if stdenv.buildPlatform.isDarwin
+    then [ buildPackages.darwin.apple_sdk_11_0.stdenv.cc ]
+    else [ buildPackages.stdenv.cc ]
+  ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform)
     pkgsBuildBuild.guile_3_0;
   nativeBuildInputs = [
     makeWrapper
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 15a6d6b39c89..2f099379b51b 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -18371,9 +18371,9 @@ with pkgs;
   # Needed for autogen
   guile_2_0 = callPackage ../development/interpreters/guile/2.0.nix { };
 
-  guile_2_2 = callPackage ../development/interpreters/guile/2.2.nix { };
+  guile_2_2 = darwin.apple_sdk_11_0.callPackage ../development/interpreters/guile/2.2.nix { };
 
-  guile_3_0 = callPackage ../development/interpreters/guile/3.0.nix { };
+  guile_3_0 = darwin.apple_sdk_11_0.callPackage ../development/interpreters/guile/3.0.nix { };
 
   guile = guile_3_0;