diff --git a/pkgs/development/python-modules/unicorn/avoid-distutils-python312.patch b/pkgs/development/python-modules/unicorn/avoid-distutils-python312.patch
new file mode 100644
index 000000000000..904538880a22
--- /dev/null
+++ b/pkgs/development/python-modules/unicorn/avoid-distutils-python312.patch
@@ -0,0 +1,29 @@
+From bcc65c0be18fc6ea6ec39da89d0de77544fa18c7 Mon Sep 17 00:00:00 2001
+From: Mrmaxmeier <Mrmaxmeier@gmail.com>
+Date: Tue, 9 Jul 2024 17:41:08 +0200
+Subject: [PATCH] Drop removed `distutils` import in favor of `sysconfig`
+
+This patch is available online as https://github.com/unicorn-engine/unicorn/pull/1973
+
+diff --git a/unicorn/unicorn.py b/unicorn/unicorn.py
+index 2e6a938f43..7204b8215f 100644
+--- a/unicorn/unicorn.py
++++ b/unicorn/unicorn.py
+@@ -2,7 +2,7 @@
+ from __future__ import annotations
+ import ctypes
+ import ctypes.util
+-import distutils.sysconfig
++import sysconfig
+ from functools import wraps
+ from typing import Any, Callable, List, Tuple, Union
+ import pkg_resources
+@@ -85,7 +85,7 @@ def _load_lib(path, lib_name):
+               pkg_resources.resource_filename(__name__, 'lib'),
+               os.path.join(os.path.split(__file__)[0], 'lib'),
+               '',
+-              distutils.sysconfig.get_python_lib(),
++              sysconfig.get_path('platlib'),
+               "/usr/local/lib/" if sys.platform == 'darwin' else '/usr/lib64',
+               os.getenv('PATH', '')]
+ 
diff --git a/pkgs/development/python-modules/unicorn/default.nix b/pkgs/development/python-modules/unicorn/default.nix
index a684d0fda817..de3a0f6a3040 100644
--- a/pkgs/development/python-modules/unicorn/default.nix
+++ b/pkgs/development/python-modules/unicorn/default.nix
@@ -15,6 +15,11 @@ buildPythonPackage rec {
 
   sourceRoot = "${src.name}/bindings/python";
 
+  patches = [
+    # Python 3.12 compatibility: Drop removed `distutils` import in favor of `sysconfig`
+    ./avoid-distutils-python312.patch
+  ];
+
   prePatch = ''
     ln -s ${unicorn-emu}/lib/libunicorn.* prebuilt/
   '';