diff --git a/pkgs/development/python-modules/cryptography/default.nix b/pkgs/development/python-modules/cryptography/default.nix
index 11f6406d4238..d9b3a68715ae 100644
--- a/pkgs/development/python-modules/cryptography/default.nix
+++ b/pkgs/development/python-modules/cryptography/default.nix
@@ -22,7 +22,7 @@
 
 buildPythonPackage rec {
   pname = "cryptography";
-  version = "46.0.1"; # Also update the hash in vectors.nix
+  version = "46.0.2";
   pyproject = true;
 
   disabled = pythonOlder "3.7";
@@ -31,7 +31,7 @@ buildPythonPackage rec {
     owner = "pyca";
     repo = "cryptography";
     tag = version;
-    hash = "sha256-saTHFKSJa9gjtEp6uGAHsvzFE3yPeck1WGdIE1+9kgs=";
+    hash = "sha256-gsEHKEYiMw2eliEpxwzFGDetOp77PivlMoBD3HBbbFA=";
   };
 
   cargoDeps = rustPlatform.fetchCargoVendor {
@@ -83,7 +83,7 @@ buildPythonPackage rec {
     vectors = cryptography-vectors;
   };
 
-  meta = with lib; {
+  meta = {
     description = "Package which provides cryptographic recipes and primitives";
     longDescription = ''
       Cryptography includes both high level recipes and low level interfaces to
@@ -91,13 +91,12 @@ buildPythonPackage rec {
       digests, and key derivation functions.
     '';
     homepage = "https://github.com/pyca/cryptography";
-    changelog =
-      "https://cryptography.io/en/latest/changelog/#v" + replaceStrings [ "." ] [ "-" ] version;
-    license = with licenses; [
+    changelog = "https://cryptography.io/en/latest/changelog/#v" + lib.replaceString "." "-" version;
+    license = with lib.licenses; [
       asl20
       bsd3
       psfl
     ];
-    maintainers = with maintainers; [ mdaniels5757 ];
+    maintainers = with lib.maintainers; [ mdaniels5757 ];
   };
 }
diff --git a/pkgs/development/python-modules/cryptography/vectors.nix b/pkgs/development/python-modules/cryptography/vectors.nix
index 0a9a1a5d5894..f8614e08a240 100644
--- a/pkgs/development/python-modules/cryptography/vectors.nix
+++ b/pkgs/development/python-modules/cryptography/vectors.nix
@@ -1,22 +1,29 @@
 {
   lib,
   buildPythonPackage,
-  fetchPypi,
   cryptography,
+  fetchpatch2,
   uv-build,
 }:
 
 buildPythonPackage rec {
   pname = "cryptography-vectors";
   # The test vectors must have the same version as the cryptography package
-  inherit (cryptography) version;
+  inherit (cryptography) version src;
   pyproject = true;
 
-  src = fetchPypi {
-    pname = "cryptography_vectors";
-    inherit version;
-    hash = "sha256-B40Sh84rRdJGtCxs+545Dh96+hdsGZsL1t6p1s6Jou4=";
-  };
+  sourceRoot = "${src.name}/vectors";
+
+  patches = [
+    # https://github.com/NixOS/nixpkgs/pull/449568
+    (fetchpatch2 {
+      name = "uv-build.patch";
+      url = "https://github.com/pyca/cryptography/commit/5f311c1cbe09ddea6136b0bb737fb7df6df1b923.patch?full_index=1";
+      stripLen = 1;
+      includes = [ "pyproject.toml" ];
+      hash = "sha256-OdHK0OGrvOi3mS0q+v8keDLvKxtgQkDkHQSYnmC/vd4=";
+    })
+  ];
 
   build-system = [ uv-build ];