diff --git a/pkgs/development/python-modules/acme-tiny/default.nix b/pkgs/development/python-modules/acme-tiny/default.nix
index c0ddb81a1920..368bb2cc2f85 100644
--- a/pkgs/development/python-modules/acme-tiny/default.nix
+++ b/pkgs/development/python-modules/acme-tiny/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   setuptools-scm,
   fusepy,
   fuse,
@@ -11,7 +12,7 @@
 buildPythonPackage rec {
   pname = "acme-tiny";
   version = "5.0.1";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
@@ -19,12 +20,15 @@ buildPythonPackage rec {
   };
 
   patchPhase = ''
-    substituteInPlace acme_tiny.py --replace '"openssl"' '"${openssl.bin}/bin/openssl"'
-    substituteInPlace tests/test_module.py --replace '"openssl"' '"${openssl.bin}/bin/openssl"'
-    substituteInPlace tests/utils.py --replace /etc/ssl/openssl.cnf ${openssl.out}/etc/ssl/openssl.cnf
+    substituteInPlace acme_tiny.py --replace-fail '"openssl"' '"${openssl.bin}/bin/openssl"'
+    substituteInPlace tests/test_module.py --replace-fail '"openssl"' '"${openssl.bin}/bin/openssl"'
+    substituteInPlace tests/utils.py --replace-fail /etc/ssl/openssl.cnf ${openssl.out}/etc/ssl/openssl.cnf
   '';
 
-  buildInputs = [ setuptools-scm ];
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
 
   nativeCheckInputs = [
     fusepy
diff --git a/pkgs/development/python-modules/adb-enhanced/default.nix b/pkgs/development/python-modules/adb-enhanced/default.nix
index 7ef10347207c..ad33e08ef8a9 100644
--- a/pkgs/development/python-modules/adb-enhanced/default.nix
+++ b/pkgs/development/python-modules/adb-enhanced/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   docopt,
   fetchFromGitHub,
+  setuptools,
   jdk11,
   psutil,
   pythonOlder,
@@ -11,25 +12,27 @@
 buildPythonPackage rec {
   pname = "adb-enhanced";
   version = "2.5.24";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
   src = fetchFromGitHub {
     owner = "ashishb";
-    repo = pname;
+    repo = "adb-enhanced";
     rev = "refs/tags/${version}";
     hash = "sha256-0HxeL6VGM+HTiAxs3NFRcEFbmH9q+0/pJdGyF1hl4hU=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     psutil
     docopt
   ];
 
   postPatch = ''
     substituteInPlace adbe/adb_enhanced.py \
-      --replace "cmd = 'java" "cmd = '${jdk11}/bin/java"
+      --replace-fail "cmd = 'java" "cmd = '${jdk11}/bin/java"
   '';
 
   # Disable tests because they require a dedicated Android emulator
diff --git a/pkgs/development/python-modules/aiolip/default.nix b/pkgs/development/python-modules/aiolip/default.nix
index 5baebc529b02..06c23bc68bea 100644
--- a/pkgs/development/python-modules/aiolip/default.nix
+++ b/pkgs/development/python-modules/aiolip/default.nix
@@ -3,26 +3,29 @@
   buildPythonPackage,
   fetchFromGitHub,
   pytestCheckHook,
+  setuptools,
   pythonOlder,
 }:
 
 buildPythonPackage rec {
   pname = "aiolip";
   version = "1.1.6";
-  format = "setuptools";
+  pyproject = true;
   disabled = pythonOlder "3.5";
 
   src = fetchFromGitHub {
     owner = "bdraco";
-    repo = pname;
+    repo = "aiolip";
     rev = version;
     sha256 = "1bgmcl8q1p6f2xm3w2qylvla6vf6bd1p2hfwj4l8w6w0w04vr02g";
   };
 
+  build-system = [ setuptools ];
+
   nativeCheckInputs = [ pytestCheckHook ];
 
   postPatch = ''
-    substituteInPlace setup.py --replace "'pytest-runner'," ""
+    substituteInPlace setup.py --replace-fail "'pytest-runner'," ""
   '';
 
   pythonImportsCheck = [ "aiolip" ];
diff --git a/pkgs/development/python-modules/ambee/default.nix b/pkgs/development/python-modules/ambee/default.nix
index 45dbce4ff1d4..91cf9f27b2e1 100644
--- a/pkgs/development/python-modules/ambee/default.nix
+++ b/pkgs/development/python-modules/ambee/default.nix
@@ -16,7 +16,7 @@ buildPythonPackage rec {
   pname = "ambee";
   version = "0.4.0";
   disabled = pythonOlder "3.8";
-  format = "pyproject";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "frenck";
@@ -25,9 +25,9 @@ buildPythonPackage rec {
     hash = "sha256-2wX2CLr6kdVw2AGPW6DmYI2OBfQFI/iWVorok2d3wx4=";
   };
 
-  nativeBuildInputs = [ poetry-core ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     aiohttp
     yarl
   ];
@@ -42,7 +42,7 @@ buildPythonPackage rec {
   postPatch = ''
     # Upstream doesn't set a version for the pyproject.toml
     substituteInPlace pyproject.toml \
-      --replace "0.0.0" "${version}"
+      --replace-fail "0.0.0" "${version}"
   '';
 
   pythonImportsCheck = [ "ambee" ];
diff --git a/pkgs/development/python-modules/atc-ble/default.nix b/pkgs/development/python-modules/atc-ble/default.nix
index 76e572401904..1b099a8d0f41 100644
--- a/pkgs/development/python-modules/atc-ble/default.nix
+++ b/pkgs/development/python-modules/atc-ble/default.nix
@@ -6,6 +6,7 @@
   poetry-core,
   pycryptodomex,
   pytestCheckHook,
+  pytest-cov-stub,
   pythonOlder,
   sensor-state-data,
 }:
@@ -13,31 +14,29 @@
 buildPythonPackage rec {
   pname = "atc-ble";
   version = "0.1.0";
-  format = "pyproject";
+  pyproject = true;
 
   disabled = pythonOlder "3.9";
 
   src = fetchFromGitHub {
     owner = "Bluetooth-Devices";
-    repo = pname;
+    repo = "atc-ble";
     rev = "refs/tags/v${version}";
     hash = "sha256-rwOFKxUlbbNIDJRdCmZpHstXwxcTnvlExgcVDdGbIVY=";
   };
 
-  postPatch = ''
-    substituteInPlace pyproject.toml \
-      --replace " --cov=atc_ble --cov-report=term-missing:skip-covered" ""
-  '';
+  build-system = [ poetry-core ];
 
-  nativeBuildInputs = [ poetry-core ];
-
-  propagatedBuildInputs = [
+  dependencies = [
     bluetooth-sensor-state-data
     pycryptodomex
     sensor-state-data
   ];
 
-  nativeCheckInputs = [ pytestCheckHook ];
+  nativeCheckInputs = [
+    pytestCheckHook
+    pytest-cov-stub
+  ];
 
   pythonImportsCheck = [ "atc_ble" ];
 
diff --git a/pkgs/development/python-modules/autarco/default.nix b/pkgs/development/python-modules/autarco/default.nix
index 0ecb14291c3a..f9e843ec7a57 100644
--- a/pkgs/development/python-modules/autarco/default.nix
+++ b/pkgs/development/python-modules/autarco/default.nix
@@ -8,6 +8,7 @@
   orjson,
   poetry-core,
   pytest-asyncio,
+  pytest-cov-stub,
   pytestCheckHook,
   pythonOlder,
   syrupy,
@@ -33,8 +34,7 @@ buildPythonPackage rec {
   postPatch = ''
     # Upstream doesn't set a version for the pyproject.toml
     substituteInPlace pyproject.toml \
-      --replace "0.0.0" "${version}" \
-      --replace "--cov" ""
+      --replace-fail "0.0.0" "${version}"
   '';
 
   build-system = [ poetry-core ];
@@ -51,6 +51,7 @@ buildPythonPackage rec {
   nativeCheckInputs = [
     aresponses
     pytest-asyncio
+    pytest-cov-stub
     pytestCheckHook
     syrupy
   ];
diff --git a/pkgs/development/python-modules/avro3k/default.nix b/pkgs/development/python-modules/avro3k/default.nix
index a2e9c344c564..cc85bb4611a6 100644
--- a/pkgs/development/python-modules/avro3k/default.nix
+++ b/pkgs/development/python-modules/avro3k/default.nix
@@ -2,13 +2,14 @@
   lib,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   isPy3k,
 }:
 
 buildPythonPackage rec {
   pname = "avro3k";
   version = "1.7.7-SNAPSHOT";
-  format = "setuptools";
+  pyproject = true;
   disabled = !isPy3k;
 
   src = fetchPypi {
@@ -19,9 +20,11 @@ buildPythonPackage rec {
   # setuptools.extern.packaging.version.InvalidVersion: Invalid version: '1.7.7-SNAPSHOT'
   postPatch = ''
     substituteInPlace setup.py \
-      --replace "1.7.7-SNAPSHOT" "1.7.7"
+      --replace-fail "1.7.7-SNAPSHOT" "1.7.7"
   '';
 
+  build-system = [ setuptools ];
+
   doCheck = false; # No such file or directory: './run_tests.py
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/azure-mgmt-commerce/default.nix b/pkgs/development/python-modules/azure-mgmt-commerce/default.nix
index 8668ecb99d52..93875a62e84e 100644
--- a/pkgs/development/python-modules/azure-mgmt-commerce/default.nix
+++ b/pkgs/development/python-modules/azure-mgmt-commerce/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   msrestazure,
   azure-common,
   azure-mgmt-core,
@@ -11,7 +12,7 @@
 buildPythonPackage rec {
   pname = "azure-mgmt-commerce";
   version = "6.0.0";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
@@ -19,7 +20,9 @@ buildPythonPackage rec {
     sha256 = "6f5447395503b2318f451d24f8021ee08db1cac44f1c3337ea690700419626b6";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     msrestazure
     azure-common
     azure-mgmt-core
@@ -28,8 +31,6 @@ buildPythonPackage rec {
 
   prePatch = ''
     rm -f azure_bdist_wheel.py tox.ini
-    substituteInPlace setup.py \
-      --replace "wheel==0.30.0" "wheel"
     sed -i "/azure-namespace-package/c\ " setup.cfg
   '';
 
@@ -43,8 +44,6 @@ buildPythonPackage rec {
     description = "This is the Microsoft Azure Commerce Management Client Library";
     homepage = "https://github.com/Azure/azure-sdk-for-python";
     license = licenses.mit;
-    maintainers = with maintainers; [
-      maxwilson
-    ];
+    maintainers = with maintainers; [ maxwilson ];
   };
 }
diff --git a/pkgs/development/python-modules/azure-mgmt-consumption/default.nix b/pkgs/development/python-modules/azure-mgmt-consumption/default.nix
index b300fe7f17b6..5e47775d2b1e 100644
--- a/pkgs/development/python-modules/azure-mgmt-consumption/default.nix
+++ b/pkgs/development/python-modules/azure-mgmt-consumption/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   msrestazure,
   azure-common,
   azure-mgmt-core,
@@ -11,7 +12,7 @@
 buildPythonPackage rec {
   pname = "azure-mgmt-consumption";
   version = "10.0.0";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
@@ -19,7 +20,9 @@ buildPythonPackage rec {
     hash = "sha256-BqCGQ2wXN/d6uGiU1R9Zc7bg+l7fVlWOTCllieurkTA=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     msrestazure
     azure-common
     azure-mgmt-core
@@ -28,8 +31,6 @@ buildPythonPackage rec {
 
   preBuild = ''
     rm -f azure_bdist_wheel.py
-    substituteInPlace setup.cfg \
-      --replace "azure-namespace-package = azure-mgmt-nspkg" ""
   '';
 
   pythonNamespaces = [ "azure.mgmt" ];
diff --git a/pkgs/development/python-modules/azure-mgmt-relay/default.nix b/pkgs/development/python-modules/azure-mgmt-relay/default.nix
index ced59697c8e3..0086fa381973 100644
--- a/pkgs/development/python-modules/azure-mgmt-relay/default.nix
+++ b/pkgs/development/python-modules/azure-mgmt-relay/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   msrestazure,
   azure-common,
   azure-mgmt-core,
@@ -11,7 +12,7 @@
 buildPythonPackage rec {
   pname = "azure-mgmt-relay";
   version = "1.1.0";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
@@ -19,7 +20,9 @@ buildPythonPackage rec {
     sha256 = "c93b7550e64b6734bf23ce57ca974a3ea929b734c58d1fe3669728c4fd2d2eb3";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     msrestazure
     azure-common
     azure-mgmt-core
@@ -28,8 +31,6 @@ buildPythonPackage rec {
 
   preBuild = ''
     rm -f azure_bdist_wheel.py
-    substituteInPlace setup.cfg \
-      --replace "azure-namespace-package = azure-mgmt-nspkg" ""
   '';
 
   pythonNamespaces = [ "azure.mgmt" ];
diff --git a/pkgs/development/python-modules/batchgenerators/default.nix b/pkgs/development/python-modules/batchgenerators/default.nix
index e07567ff1be0..6c02b8e8cb20 100644
--- a/pkgs/development/python-modules/batchgenerators/default.nix
+++ b/pkgs/development/python-modules/batchgenerators/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   pythonOlder,
   fetchFromGitHub,
+  setuptools,
   pytestCheckHook,
   future,
   numpy,
@@ -16,18 +17,20 @@
 buildPythonPackage rec {
   pname = "batchgenerators";
   version = "0.25";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
   src = fetchFromGitHub {
     owner = "MIC-DKFZ";
-    repo = pname;
+    repo = "batchgenerators";
     rev = "v${version}";
     hash = "sha256-L2mWH2t8PN9o1M67KDdl1Tj2ZZ02MY4icsJY2VNrj3A=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     future
     numpy
     pillow
@@ -38,10 +41,7 @@ buildPythonPackage rec {
   ];
 
   # see https://github.com/MIC-DKFZ/batchgenerators/pull/78
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace '"unittest2",' ""
-  '';
+  pythonRemoveDeps = [ "unittest2" ];
 
   nativeCheckInputs = [ pytestCheckHook ];
 
diff --git a/pkgs/development/python-modules/block-io/default.nix b/pkgs/development/python-modules/block-io/default.nix
index 65190dcca668..d3a7b7213d6b 100644
--- a/pkgs/development/python-modules/block-io/default.nix
+++ b/pkgs/development/python-modules/block-io/default.nix
@@ -13,7 +13,7 @@
 buildPythonPackage rec {
   pname = "block-io";
   version = "2.0.6";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.6";
 
@@ -22,7 +22,11 @@ buildPythonPackage rec {
     hash = "sha256-M7czfpagXqoWWSu4enB3Z2hc2GtAaskI6cnJzJdpC8I=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  pythonRelaxDeps = [ "base58" ];
+
+  dependencies = [
     base58
     bitcoin-utils-fork-minimal
     pycryptodome
@@ -30,11 +34,6 @@ buildPythonPackage rec {
     setuptools
   ];
 
-  preConfigure = ''
-    substituteInPlace setup.py \
-      --replace "base58==2.1.0" "base58>=2.1.0"
-  '';
-
   # Tests needs a BlockIO API key to run properly
   # https://github.com/BlockIo/block_io-python/blob/79006bc8974544b70a2d8e9f19c759941d32648e/test.py#L18
   doCheck = false;
diff --git a/pkgs/development/python-modules/boiboite-opener-framework/default.nix b/pkgs/development/python-modules/boiboite-opener-framework/default.nix
index d9936a7593e9..9be58802c5e3 100644
--- a/pkgs/development/python-modules/boiboite-opener-framework/default.nix
+++ b/pkgs/development/python-modules/boiboite-opener-framework/default.nix
@@ -23,10 +23,7 @@ buildPythonPackage rec {
     hash = "sha256-atKqHRX24UjF/9Dy0aYXAN+80nBJKCd07FmaR5Vl1q4=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "scapy==2.5.0rc1" "scapy"
-  '';
+  pythonRelaxDeps = [ "scapy" ];
 
   build-system = [ setuptools ];
 
diff --git a/pkgs/development/python-modules/celery-singleton/default.nix b/pkgs/development/python-modules/celery-singleton/default.nix
index de011ca70d0b..3d75770e932a 100644
--- a/pkgs/development/python-modules/celery-singleton/default.nix
+++ b/pkgs/development/python-modules/celery-singleton/default.nix
@@ -14,7 +14,7 @@
 buildPythonPackage rec {
   pname = "celery-singleton";
   version = "0.3.1";
-  format = "pyproject";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "steinitzu";
@@ -33,9 +33,9 @@ buildPythonPackage rec {
     })
   ];
 
-  nativeBuildInputs = [ poetry-core ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     celery
     redis
   ];
diff --git a/pkgs/development/python-modules/cemm/default.nix b/pkgs/development/python-modules/cemm/default.nix
index 83ff151d7c8b..39159b404162 100644
--- a/pkgs/development/python-modules/cemm/default.nix
+++ b/pkgs/development/python-modules/cemm/default.nix
@@ -16,7 +16,7 @@
 buildPythonPackage rec {
   pname = "cemm";
   version = "0.5.1";
-  format = "pyproject";
+  pyproject = true;
 
   disabled = pythonOlder "3.9";
 
@@ -38,12 +38,12 @@ buildPythonPackage rec {
 
   postPatch = ''
     substituteInPlace pyproject.toml \
-      --replace '"0.0.0"' '"${version}"'
+      --replace-fail '"0.0.0"' '"${version}"'
   '';
 
-  nativeBuildInputs = [ poetry-core ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     aiohttp
     yarl
   ];
diff --git a/pkgs/development/python-modules/ciscoconfparse/default.nix b/pkgs/development/python-modules/ciscoconfparse/default.nix
index 1643c6acfa47..478591d51df3 100644
--- a/pkgs/development/python-modules/ciscoconfparse/default.nix
+++ b/pkgs/development/python-modules/ciscoconfparse/default.nix
@@ -15,13 +15,13 @@
 buildPythonPackage rec {
   pname = "ciscoconfparse";
   version = "1.7.24";
-  format = "pyproject";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
   src = fetchFromGitHub {
     owner = "mpenning";
-    repo = pname;
+    repo = "ciscoconfparse";
     rev = "refs/tags/${version}";
     hash = "sha256-vL/CQdYcOP356EyRToviWylP1EBtxmeov6qkhfQNZ2Y=";
   };
@@ -35,16 +35,14 @@ buildPythonPackage rec {
     sed -i '/requires-python/d' pyproject.toml
 
     substituteInPlace pyproject.toml \
-      --replace '"poetry>=1.3.2",' ""
+      --replace-fail '"poetry>=1.3.2",' ""
 
     patchShebangs tests
   '';
 
-  nativeBuildInputs = [
-    poetry-core
-  ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     passlib
     deprecat
     dnspython
diff --git a/pkgs/development/python-modules/databricks-connect/default.nix b/pkgs/development/python-modules/databricks-connect/default.nix
index 89e85bcd7b0b..7f06b59df3e2 100644
--- a/pkgs/development/python-modules/databricks-connect/default.nix
+++ b/pkgs/development/python-modules/databricks-connect/default.nix
@@ -3,6 +3,7 @@
   jdk8,
   buildPythonPackage,
   fetchPypi,
+  setuptools,
   six,
   py4j,
   pythonOlder,
@@ -11,7 +12,7 @@
 buildPythonPackage rec {
   pname = "databricks-connect";
   version = "11.3.33";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -22,7 +23,9 @@ buildPythonPackage rec {
 
   sourceRoot = ".";
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     py4j
     six
     jdk8
@@ -31,14 +34,11 @@ buildPythonPackage rec {
   # requires network access
   doCheck = false;
 
-  prePatch = ''
-    substituteInPlace setup.py \
-      --replace "py4j==0.10.9" "py4j"
-  '';
+  pythonRelaxDeps = [ "py4j" ];
 
   preFixup = ''
     substituteInPlace "$out/bin/find-spark-home" \
-      --replace find_spark_home.py .find_spark_home.py-wrapped
+      --replace-fail find_spark_home.py .find_spark_home.py-wrapped
   '';
 
   pythonImportsCheck = [
diff --git a/pkgs/development/python-modules/django-payments/default.nix b/pkgs/development/python-modules/django-payments/default.nix
index 714bc0253bfe..935808b32c79 100644
--- a/pkgs/development/python-modules/django-payments/default.nix
+++ b/pkgs/development/python-modules/django-payments/default.nix
@@ -9,6 +9,7 @@
   mercadopago,
   pythonOlder,
   requests,
+  setuptools,
   setuptools-scm,
   sphinx-rtd-theme,
   stripe,
@@ -18,7 +19,7 @@
 buildPythonPackage rec {
   pname = "django-payments";
   version = "2.0.0";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -31,12 +32,15 @@ buildPythonPackage rec {
 
   postPatch = ''
     substituteInPlace setup.py \
-      --replace "django-phonenumber-field[phonenumberslite]" "django-phonenumber-field"
+      --replace-fail "django-phonenumber-field[phonenumberslite]" "django-phonenumber-field"
   '';
 
-  nativeBuildInputs = [ setuptools-scm ];
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     django
     django-phonenumber-field
     requests
diff --git a/pkgs/development/python-modules/django-scim2/default.nix b/pkgs/development/python-modules/django-scim2/default.nix
index 2c9c2922f481..bb4b5d7c508c 100644
--- a/pkgs/development/python-modules/django-scim2/default.nix
+++ b/pkgs/development/python-modules/django-scim2/default.nix
@@ -19,11 +19,11 @@
 buildPythonPackage rec {
   pname = "django-scim2";
   version = "0.19.0";
-  format = "pyproject";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "15five";
-    repo = pname;
+    repo = "django-scim2";
     rev = "refs/tags/${version}";
     hash = "sha256-larDh4f9/xVr11/n/WfkJ2Tx45DMQqyK3ZzkWAvzeig=";
   };
@@ -31,13 +31,13 @@ buildPythonPackage rec {
   # remove this when upstream releases a new version > 0.19.0
   postPatch = ''
     substituteInPlace pyproject.toml \
-      --replace "poetry>=0.12" "poetry-core>=1.5.2" \
-      --replace "poetry.masonry.api" "poetry.core.masonry.api"
+      --replace-fail "poetry>=0.12" "poetry-core>=1.5.2" \
+      --replace-fail "poetry.masonry.api" "poetry.core.masonry.api"
   '';
 
-  nativeBuildInputs = [ poetry-core ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     django
     scim2-filter-parser
   ];
diff --git a/pkgs/development/python-modules/eiswarnung/default.nix b/pkgs/development/python-modules/eiswarnung/default.nix
index 0806d423a4b8..ff5fb07f11c0 100644
--- a/pkgs/development/python-modules/eiswarnung/default.nix
+++ b/pkgs/development/python-modules/eiswarnung/default.nix
@@ -6,6 +6,7 @@
   fetchFromGitHub,
   poetry-core,
   pytest-asyncio,
+  pytest-cov-stub,
   pytestCheckHook,
   pythonOlder,
   pytz,
@@ -15,7 +16,7 @@
 buildPythonPackage rec {
   pname = "eiswarnung";
   version = "2.0.0";
-  format = "pyproject";
+  pyproject = true;
 
   disabled = pythonOlder "3.11";
 
@@ -30,14 +31,14 @@ buildPythonPackage rec {
 
   postPatch = ''
     substituteInPlace pyproject.toml \
-      --replace '"0.0.0"' '"${version}"' \
-      --replace 'addopts = "--cov"' "" \
-      --replace 'pytz = ">=2022.7.1,<2024.0.0"' 'pytz = "*"'
+      --replace-fail '"0.0.0"' '"${version}"'
   '';
 
-  nativeBuildInputs = [ poetry-core ];
+  pythonRelaxDeps = [ "pytz" ];
 
-  propagatedBuildInputs = [
+  build-system = [ poetry-core ];
+
+  dependencies = [
     aiohttp
     pytz
     yarl
@@ -46,6 +47,7 @@ buildPythonPackage rec {
   nativeCheckInputs = [
     aresponses
     pytest-asyncio
+    pytest-cov-stub
     pytestCheckHook
   ];
 
diff --git a/pkgs/development/python-modules/entrance/default.nix b/pkgs/development/python-modules/entrance/default.nix
index 121c57a89106..960e629d1474 100644
--- a/pkgs/development/python-modules/entrance/default.nix
+++ b/pkgs/development/python-modules/entrance/default.nix
@@ -4,6 +4,7 @@
   buildPythonPackage,
   pythonOlder,
   routerFeatures,
+  setuptools,
   janus,
   ncclient,
   paramiko,
@@ -18,7 +19,7 @@ let
     if routerFeatures then
       {
         prePatch = ''
-          substituteInPlace ./setup.py --replace "extra_deps = []" "extra_deps = router_feature_deps"
+          substituteInPlace ./setup.py --replace-fail "extra_deps = []" "extra_deps = router_feature_deps"
         '';
         extraBuildInputs = [
           janus
@@ -36,7 +37,7 @@ in
 buildPythonPackage rec {
   pname = "entrance";
   version = "1.1.20";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
@@ -49,7 +50,9 @@ buildPythonPackage rec {
   # No useful tests
   doCheck = false;
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     pyyaml
     sanic
   ] ++ opts.extraBuildInputs;
diff --git a/pkgs/development/python-modules/envoy-reader/default.nix b/pkgs/development/python-modules/envoy-reader/default.nix
index 3f91c0c69e6a..46a8249d9e2f 100644
--- a/pkgs/development/python-modules/envoy-reader/default.nix
+++ b/pkgs/development/python-modules/envoy-reader/default.nix
@@ -4,6 +4,7 @@
   buildPythonPackage,
   envoy-utils,
   fetchFromGitHub,
+  setuptools,
   httpx,
   pyjwt,
   pytest-asyncio,
@@ -16,7 +17,7 @@
 buildPythonPackage rec {
   pname = "envoy-reader";
   version = "0.21.3";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -27,7 +28,9 @@ buildPythonPackage rec {
     hash = "sha256-aIpZ4ln4L57HwK8H0FqsyNnXosnAp3ingrJI6/MPS90=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     beautifulsoup4
     envoy-utils
     httpx
@@ -41,10 +44,11 @@ buildPythonPackage rec {
     respx
   ];
 
+  pythonRelaxDeps = [ "pyjwt" ];
+
   postPatch = ''
     substituteInPlace setup.py \
-      --replace "pytest-runner>=5.2" "" \
-      --replace "pyjwt==2.1.0" "pyjwt>=2.1.0"
+      --replace-fail "pytest-runner>=5.2" ""
   '';
 
   pythonImportsCheck = [ "envoy_reader" ];
diff --git a/pkgs/development/python-modules/fastapi-mail/default.nix b/pkgs/development/python-modules/fastapi-mail/default.nix
index feb52ac8b3f1..16a3e0c67666 100644
--- a/pkgs/development/python-modules/fastapi-mail/default.nix
+++ b/pkgs/development/python-modules/fastapi-mail/default.nix
@@ -33,16 +33,19 @@ buildPythonPackage rec {
     hash = "sha256-2iTZqZIxlt1GKhElasTcnys18UbNNDwHoZziHBOIGBo=";
   };
 
+  pythonRelaxDeps = [
+    "aiosmtplib"
+    "pydantic"
+  ];
+
   postPatch = ''
     substituteInPlace pyproject.toml \
-      --replace 'version = "1.2.5"' 'version = "${version}"' \
-      --replace 'aiosmtplib = "^2.0"' 'aiosmtplib = "*"' \
-      --replace 'pydantic = "^2.0"' 'pydantic = "*"' \
+      --replace-fail 'version = "1.2.5"' 'version = "${version}"'
   '';
 
-  nativeBuildInputs = [ poetry-core ];
+  build-system = [ poetry-core ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     aioredis
     aiosmtplib
     blinker
diff --git a/pkgs/development/python-modules/fhir-py/default.nix b/pkgs/development/python-modules/fhir-py/default.nix
index 6e156e7da72b..f03666938c48 100644
--- a/pkgs/development/python-modules/fhir-py/default.nix
+++ b/pkgs/development/python-modules/fhir-py/default.nix
@@ -9,6 +9,7 @@
   requests,
   pytestCheckHook,
   pytest-asyncio,
+  pytest-cov-stub,
   responses,
 }:
 
@@ -26,15 +27,9 @@ buildPythonPackage rec {
     hash = "sha256-kYqoRso1ypN5novRxMMzz1h2NGNybbw5lK4+HErG79I=";
   };
 
-  preBuild = ''
-    substituteInPlace pyproject.toml  \
-      --replace "--cov=fhirpy" ""  \
-      --replace "--cov-report=xml" ""
-  '';
+  build-system = [ flit-core ];
 
-  nativeBuildInputs = [ flit-core ];
-
-  propagatedBuildInputs = [
+  dependencies = [
     aiohttp
     pytz
     requests
@@ -43,6 +38,7 @@ buildPythonPackage rec {
   nativeCheckInputs = [
     pytestCheckHook
     pytest-asyncio
+    pytest-cov-stub
     responses
   ];
 
diff --git a/pkgs/development/python-modules/finvizfinance/default.nix b/pkgs/development/python-modules/finvizfinance/default.nix
index 7e0ad12fd798..0c3ff788d468 100644
--- a/pkgs/development/python-modules/finvizfinance/default.nix
+++ b/pkgs/development/python-modules/finvizfinance/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   pythonOlder,
   fetchFromGitHub,
+  setuptools,
   beautifulsoup4,
   datetime,
   lxml,
@@ -15,7 +16,7 @@
 buildPythonPackage rec {
   pname = "finvizfinance";
   version = "1.0.1";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.5";
 
@@ -26,17 +27,14 @@ buildPythonPackage rec {
     hash = "sha256-4aR1x9GgbxnJUpn1+i95djZEVBFTAIzhMLxHe2FaciY=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "bs4" "beautifulsoup4"
-  '';
+  build-system = [ setuptools ];
 
   nativeCheckInputs = [
     pytest-mock
     pytestCheckHook
   ];
 
-  propagatedBuildInputs = [
+  dependencies = [
     beautifulsoup4
     datetime
     lxml
diff --git a/pkgs/development/python-modules/flake8-future-import/default.nix b/pkgs/development/python-modules/flake8-future-import/default.nix
index 88d7f959b89a..8ea9f8c7d73d 100644
--- a/pkgs/development/python-modules/flake8-future-import/default.nix
+++ b/pkgs/development/python-modules/flake8-future-import/default.nix
@@ -6,6 +6,7 @@
   isPy38,
   isPy39,
   pythonAtLeast,
+  setuptools,
   flake8,
   six,
   python,
@@ -14,7 +15,7 @@
 buildPythonPackage rec {
   pname = "flake8-future-import";
   version = "0.4.7";
-  format = "setuptools";
+  pyproject = true;
 
   # PyPI tarball doesn't include the test suite
   src = fetchFromGitHub {
@@ -36,10 +37,12 @@ buildPythonPackage rec {
 
   postPatch = ''
     substituteInPlace "test_flake8_future_import.py" \
-      --replace "'flake8'" "'${lib.getExe flake8}'"
+      --replace-fail "'flake8'" "'${lib.getExe flake8}'"
   '';
 
-  propagatedBuildInputs = [ flake8 ];
+  build-system = [ setuptools ];
+
+  dependencies = [ flake8 ];
 
   nativeCheckInputs = [ six ];
 
diff --git a/pkgs/development/python-modules/flake8-polyfill/default.nix b/pkgs/development/python-modules/flake8-polyfill/default.nix
index 0c912cd7005b..faf3c0bdb030 100644
--- a/pkgs/development/python-modules/flake8-polyfill/default.nix
+++ b/pkgs/development/python-modules/flake8-polyfill/default.nix
@@ -3,6 +3,7 @@
   buildPythonPackage,
   fetchpatch,
   fetchPypi,
+  setuptools,
   flake8,
   mock,
   pep8,
@@ -12,14 +13,16 @@
 buildPythonPackage rec {
   pname = "flake8-polyfill";
   version = "1.0.2";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
     sha256 = "1nlf1mkqw856vi6782qcglqhaacb23khk9wkcgn55npnjxshhjz4";
   };
 
-  propagatedBuildInputs = [ flake8 ];
+  build-system = [ setuptools ];
+
+  dependencies = [ flake8 ];
 
   nativeCheckInputs = [
     mock
@@ -39,7 +42,7 @@ buildPythonPackage rec {
   postPatch = ''
     # Failed: [pytest] section in setup.cfg files is no longer supported, change to [tool:pytest] instead.
     substituteInPlace setup.cfg \
-      --replace pytest 'tool:pytest'
+      --replace-fail pytest 'tool:pytest'
   '';
 
   pythonImportsCheck = [ "flake8_polyfill" ];
diff --git a/pkgs/development/python-modules/flask-gravatar/default.nix b/pkgs/development/python-modules/flask-gravatar/default.nix
index 9194a9436ac6..81a29a3c56fa 100644
--- a/pkgs/development/python-modules/flask-gravatar/default.nix
+++ b/pkgs/development/python-modules/flask-gravatar/default.nix
@@ -12,13 +12,14 @@
 
   # tests
   pytestCheckHook,
+  pytest-cov-stub,
   pygments,
 }:
 
 buildPythonPackage rec {
   pname = "flask-gravatar";
   version = "0.5.0";
-  format = "setuptools";
+  pyproject = true;
 
   src = fetchPypi {
     pname = "Flask-Gravatar";
@@ -39,18 +40,18 @@ buildPythonPackage rec {
      -e "s|tests_require=tests_require,||g" \
      -e "s|extras_require=extras_require,||g" \
      -e "s|setup_requires=setup_requires,||g"
-    # pep8 is deprecated and cov not needed
+    # pep8 is deprecated
     substituteInPlace pytest.ini \
-     --replace "--pep8" "" \
-     --replace "--cov=flask_gravatar --cov-report=term-missing" ""
+     --replace-fail "--pep8" ""
   '';
 
-  nativeBuildInputs = [ setuptools ];
+  build-system = [ setuptools ];
 
-  propagatedBuildInputs = [ flask ];
+  dependencies = [ flask ];
 
   nativeCheckInputs = [
     pytestCheckHook
+    pytest-cov-stub
     pygments
   ];