diff --git a/pkgs/applications/virtualization/xen/generic/default.nix b/pkgs/applications/virtualization/xen/generic/default.nix
index 250e5a41bfc1..d4d0d235eef2 100644
--- a/pkgs/applications/virtualization/xen/generic/default.nix
+++ b/pkgs/applications/virtualization/xen/generic/default.nix
@@ -25,7 +25,7 @@ versionDefinition:
   ncurses,
   ocamlPackages,
   perl,
-  python311Packages,
+  python3Packages,
   systemdMinimal,
   xz,
   yajl,
@@ -323,6 +323,7 @@ stdenv.mkDerivation (finalAttrs: {
     "doc" # The full Xen documentation in HTML format.
     "dev" # Development headers.
     "boot" # xen.gz kernel, policy file if Flask is enabled, xen.efi if EFI is enabled.
+    # TODO: Python package to be in separate output/package.
   ];
 
   # Main Xen source.
@@ -345,10 +346,11 @@ stdenv.mkDerivation (finalAttrs: {
       flex
       pandoc
       pkg-config
+      python3Packages.setuptools
     ]
     ++ lib.lists.optionals withInternalQEMU [
       ninja
-      python311Packages.sphinx
+      python3Packages.sphinx
     ];
   buildInputs =
     [
@@ -362,7 +364,7 @@ stdenv.mkDerivation (finalAttrs: {
       lzo
       ncurses
       perl
-      python311Packages.python
+      python3Packages.python
       xz
       yajl
       zlib
@@ -373,7 +375,7 @@ stdenv.mkDerivation (finalAttrs: {
       ocamlPackages.ocaml
 
       # Python Fixes
-      python311Packages.wrapPython
+      python3Packages.wrapPython
     ]
     ++ lib.lists.optionals withInternalQEMU [
       glib
diff --git a/pkgs/applications/virtualization/xen/packages.nix b/pkgs/applications/virtualization/xen/packages.nix
index 7402edc8bc70..fe759709770f 100644
--- a/pkgs/applications/virtualization/xen/packages.nix
+++ b/pkgs/applications/virtualization/xen/packages.nix
@@ -1,6 +1,12 @@
-{ callPackage }:
+{
+  python3Packages,
+  python311Packages,
+  callPackage,
+}:
 let
   standard = {
+    # Broken with python 3.12+ when using internal QEMU due to https://github.com/NixOS/nixpkgs/issues/253751
+    python3Packages = python311Packages;
     meta = {
       description = "Standard";
       longDescription = ''
@@ -13,6 +19,7 @@ let
     };
   };
   slim = {
+    inherit python3Packages;
     meta = {
       description = "Without Internal Components";
       longDescription = ''
@@ -27,30 +34,38 @@ let
 in
 # TODO: generalise this to automatically generate both Xen variants for each ./<version>/default.nix.
 rec {
-  xen_4_19 = callPackage ./4.19/default.nix { inherit (standard) meta; };
+  xen_4_19 = callPackage ./4.19/default.nix {
+    inherit (standard) meta python3Packages;
+  };
   xen_4_19-slim = xen_4_19.override {
     withInternalQEMU = false;
     withInternalSeaBIOS = false;
     withInternalOVMF = false;
     withInternalIPXE = false;
-    inherit (slim) meta;
+    inherit (slim) meta python3Packages;
   };
 
-  xen_4_18 = callPackage ./4.18/default.nix { inherit (standard) meta; };
+  xen_4_18 = callPackage ./4.18/default.nix {
+    inherit (standard) meta python3Packages;
+  };
   xen_4_18-slim = xen_4_18.override {
     withInternalQEMU = false;
     withInternalSeaBIOS = false;
     withInternalOVMF = false;
     withInternalIPXE = false;
-    inherit (slim) meta;
+    inherit (slim) meta python3Packages;
   };
 
-  xen_4_17 = callPackage ./4.17/default.nix { inherit (standard) meta; };
+  xen_4_17 = callPackage ./4.17/default.nix {
+    inherit (standard) meta python3Packages;
+  };
   xen_4_17-slim = xen_4_17.override {
     withInternalQEMU = false;
     withInternalSeaBIOS = false;
     withInternalOVMF = false;
     withInternalIPXE = false;
     inherit (slim) meta;
+    # Broken with python 3.12+ due to distutils missing.
+    python3Packages = python311Packages;
   };
 }
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 5f4c18055d16..9376889841e9 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -17550,6 +17550,10 @@ self: super: with self; {
     inherit (pkgs) graphviz;
   };
 
+  xen = toPythonModule (pkgs.xen-slim.override {
+    python3Packages = self;
+  });
+
   xformers = callPackage ../development/python-modules/xformers { };
 
   xgboost = callPackage ../development/python-modules/xgboost {