diff --git a/pkgs/development/python-modules/affinegap/default.nix b/pkgs/development/python-modules/affinegap/default.nix
new file mode 100644
index 000000000000..6d315b347729
--- /dev/null
+++ b/pkgs/development/python-modules/affinegap/default.nix
@@ -0,0 +1,50 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  cython,
+  setuptools,
+
+  # tests
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "affinegap";
+  version = "1.12";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "dedupeio";
+    repo = "affinegap";
+    tag = "v${version}";
+    hash = "sha256-9eX41eoME5Vdtq+c04eQbMYnViy6QKOhKkafrkeMylI=";
+  };
+
+  build-system = [
+    cython
+    setuptools
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  # Prevent importing from source during test collection (only $out has compiled extensions)
+  preCheck = ''
+    rm -rf affinegap
+  '';
+
+  pythonImportsCheck = [
+    "affinegap"
+  ];
+
+  meta = {
+    description = "Cython implementation of the affine gap string distance";
+    homepage = "https://github.com/dedupeio/affinegap";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ daniel-fahey ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 99a8ce5fcd78..23224850d8a5 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -124,6 +124,8 @@ self: super: with self; {
 
   affine-gaps = callPackage ../development/python-modules/affine-gaps { };
 
+  affinegap = callPackage ../development/python-modules/affinegap { };
+
   afsapi = callPackage ../development/python-modules/afsapi { };
 
   agate = callPackage ../development/python-modules/agate { };