diff --git a/pkgs/by-name/xs/xsynth_dssi/package.nix b/pkgs/by-name/xs/xsynth_dssi/package.nix
deleted file mode 100644
index 09ee1880fcb9..000000000000
--- a/pkgs/by-name/xs/xsynth_dssi/package.nix
+++ /dev/null
@@ -1,63 +0,0 @@
-{
-  lib,
-  stdenv,
-  fetchurl,
-  alsa-lib,
-  autoconf,
-  automake,
-  dssi,
-  gtk2,
-  libjack2,
-  ladspaH,
-  ladspaPlugins,
-  liblo,
-  pkg-config,
-}:
-
-stdenv.mkDerivation rec {
-  pname = "xsynth-dssi";
-  version = "0.9.4";
-
-  src = fetchurl {
-    url = "mirror://sourceforge/dssi/${pname}-${version}.tar.gz";
-    sha256 = "00nwv2pqjbmxqdc6xdm0cljq6z05lv4y6bibmhz1kih9lm0lklnk";
-  };
-
-  nativeBuildInputs = [
-    autoconf
-    automake
-    pkg-config
-  ];
-  buildInputs = [
-    alsa-lib
-    dssi
-    gtk2
-    libjack2
-    ladspaH
-    ladspaPlugins
-    liblo
-  ];
-
-  installPhase = ''
-    mkdir -p $out/bin
-    mkdir -p $out/lib
-    cp src/Xsynth_gtk $out/bin
-    cp src/.libs/* $out/lib
-  '';
-
-  meta = {
-    description = "Classic-analog (VCOs-VCF-VCA) style software synthesizer";
-    mainProgram = "Xsynth_gtk";
-    longDescription = ''
-      Xsynth-DSSI is a classic-analog (VCOs-VCF-VCA) style software
-      synthesizer which operates as a plugin for the DSSI Soft Synth
-      Interface.  DSSI is a plugin API for software instruments (soft
-      synths) with user interfaces, permitting them to be hosted
-      in-process by audio applications.
-    '';
-    homepage = "https://dssi.sourceforge.net/download.html#Xsynth-DSSI";
-    license = lib.licenses.gpl2Plus;
-    platforms = lib.platforms.linux;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 4c31045ea85c..9a2164fa589f 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1942,6 +1942,7 @@ mapAliases {
   xorgdocs = xorg-docs; # Added 2026-01-19
   xorgsgmldoctools = xorg-sgml-doctools; # Added 2026-01-19
   xsw = throw "'xsw' has been removed due to lack of upstream maintenance"; # Added 2025-08-22
+  xsynth-dssi = throw "'xsynth-dssi' was removed due to lack of upstream maintenance and relying on gtk2"; # Added 2025-12-02
   xtrap = throw "XTrap was a proposed X11 extension that hasn't been in Xorg since X11R6 in 1994, it is deprecated and archived upstream."; # added 2025-12-13
   xulrunner = throw "'xulrunner' has been renamed to/replaced by 'firefox-unwrapped'"; # Converted to throw 2025-10-27
   xxgdb = throw "'xxgdb' seems inactive and doesn't compile with glibc 2.42"; # Added 2025-09-28