diff --git a/pkgs/desktops/gnome/core/gnome-control-center/default.nix b/pkgs/desktops/gnome/core/gnome-control-center/default.nix
index 4161598634f9..0d3b3bc5c6dd 100644
--- a/pkgs/desktops/gnome/core/gnome-control-center/default.nix
+++ b/pkgs/desktops/gnome/core/gnome-control-center/default.nix
@@ -165,6 +165,8 @@ stdenv.mkDerivation rec {
     done
   '';
 
+  separateDebugInfo = true;
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = pname;
diff --git a/pkgs/development/libraries/gnome-online-accounts/default.nix b/pkgs/development/libraries/gnome-online-accounts/default.nix
index 5344534aec5d..43eb7a2ff301 100644
--- a/pkgs/development/libraries/gnome-online-accounts/default.nix
+++ b/pkgs/development/libraries/gnome-online-accounts/default.nix
@@ -87,6 +87,8 @@ stdenv.mkDerivation rec {
 
   NIX_CFLAGS_COMPILE = "-I${glib.dev}/include/gio-unix-2.0";
 
+  separateDebugInfo = true;
+
   passthru = {
     updateScript = gnome.updateScript {
       versionPolicy = "odd-unstable";
diff --git a/pkgs/development/libraries/gvfs/default.nix b/pkgs/development/libraries/gvfs/default.nix
index d80d7f82bfd9..37a282c4ccad 100644
--- a/pkgs/development/libraries/gvfs/default.nix
+++ b/pkgs/development/libraries/gvfs/default.nix
@@ -131,6 +131,8 @@ stdenv.mkDerivation rec {
   doCheck = false; # fails with "ModuleNotFoundError: No module named 'gi'"
   doInstallCheck = doCheck;
 
+  separateDebugInfo = true;
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = pname;
diff --git a/pkgs/development/libraries/librest/1.0.nix b/pkgs/development/libraries/librest/1.0.nix
index cbd525d40b0e..130d6944e92b 100644
--- a/pkgs/development/libraries/librest/1.0.nix
+++ b/pkgs/development/libraries/librest/1.0.nix
@@ -58,6 +58,8 @@ stdenv.mkDerivation rec {
     moveToOutput "share/doc" "$devdoc"
   '';
 
+  separateDebugInfo = true;
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = pname;