diff --git a/pkgs/development/python-modules/brian2/default.nix b/pkgs/development/python-modules/brian2/default.nix
new file mode 100644
index 000000000000..52149b883060
--- /dev/null
+++ b/pkgs/development/python-modules/brian2/default.nix
@@ -0,0 +1,53 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, cython
+, jinja2
+, numpy
+, pyparsing
+, setuptools
+, sympy
+, pytest
+, pytest-xdist
+, python
+}:
+
+buildPythonPackage rec {
+  pname = "brian2";
+  version = "2.5.1";
+
+  src = fetchPypi {
+    pname = "Brian2";
+    inherit version;
+    sha256 = "sha256-x1EcS7PFCsjPYsq3Lt87SJRW4J5DE/OfdFs3NuyHiLw=";
+  };
+
+  propagatedBuildInputs = [
+    cython
+    jinja2
+    numpy
+    pyparsing
+    setuptools
+    sympy
+  ];
+
+  checkInputs = [
+    pytest
+    pytest-xdist
+  ];
+
+  checkPhase = ''
+    runHook preCheck
+    # Cython cache lies in home directory
+    export HOME=$(mktemp -d)
+    cd $HOME && ${python.interpreter} -c "import brian2;assert brian2.test()"
+    runHook postCheck
+  '';
+
+  meta = with lib; {
+    description = "A clock-driven simulator for spiking neural networks";
+    homepage = "https://briansimulator.org/";
+    license = licenses.cecill21;
+    maintainers = with maintainers; [ jiegec ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index d3a9136b83d8..8bb654b8dc5f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1421,6 +1421,8 @@ self: super: with self; {
 
   brelpy = callPackage ../development/python-modules/brelpy { };
 
+  brian2 = callPackage ../development/python-modules/brian2 { };
+
   broadlink = callPackage ../development/python-modules/broadlink { };
 
   brother = callPackage ../development/python-modules/brother { };