diff --git a/pkgs/development/python-modules/freesasa/default.nix b/pkgs/development/python-modules/freesasa/default.nix
new file mode 100644
index 000000000000..92b2359862f0
--- /dev/null
+++ b/pkgs/development/python-modules/freesasa/default.nix
@@ -0,0 +1,47 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  setuptools,
+  cython,
+  freesasa,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "freesasa";
+  version = "2.2.1";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "freesasa";
+    repo = "freesasa-python";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-/7ymItwXOemY0+IL0k6rWnJI8fAwTFjNXzTV+uf9x9A=";
+  };
+
+  postPatch = ''
+    ln -s ${freesasa.src}/* lib/
+  '';
+
+  build-system = [
+    cython
+    setuptools
+  ];
+
+  env.USE_CYTHON = true;
+
+  pythonImportsCheck = [ "freesasa" ];
+
+  nativeCheckInputs = [ pytestCheckHook ];
+
+  pytestFlagsArray = [ "test.py" ];
+
+  meta = {
+    description = "FreeSASA Python Module";
+    homepage = "https://github.com/freesasa/freesasa-python";
+    changelog = "https://github.com/freesasa/freesasa-python/blob/${src.rev}/CHANGELOG.md";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ natsukium ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 884a52331711..d7c8625ecd4e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4590,6 +4590,10 @@ self: super: with self; {
 
   freertos-gdb = callPackage ../development/python-modules/freertos-gdb { };
 
+  freesasa = callPackage ../development/python-modules/freesasa {
+    inherit (pkgs) freesasa;
+  };
+
   freetype-py = callPackage ../development/python-modules/freetype-py { };
 
   freezegun = callPackage ../development/python-modules/freezegun { };