diff --git a/pkgs/development/python-modules/py-eth-sig-utils/default.nix b/pkgs/development/python-modules/py-eth-sig-utils/default.nix
deleted file mode 100644
index bf95fb2da73f..000000000000
--- a/pkgs/development/python-modules/py-eth-sig-utils/default.nix
+++ /dev/null
@@ -1,48 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  eth-abi,
-  py-ecc,
-  pycryptodome,
-  python,
-  rlp,
-}:
-
-buildPythonPackage rec {
-  pname = "py-eth-sig-utils";
-  version = "0.4.0";
-  format = "setuptools";
-
-  src = fetchFromGitHub {
-    owner = "rmeissner";
-    repo = "py-eth-sig-utils";
-    rev = "v${version}";
-    hash = "sha256-PNvEHH5w2ptntRGzqWrqlbIzJJsT60OXg/Dh5f6Wq9k=";
-  };
-
-  propagatedBuildInputs = [
-    eth-abi
-    py-ecc
-    pycryptodome
-    rlp
-  ];
-
-  # lots of: isinstance() arg 2 must be a type or tuple of types
-  doCheck = false;
-
-  checkPhase = ''
-    ${python.interpreter} -m unittest
-  '';
-
-  pythonImportsCheck = [ "py_eth_sig_utils" ];
-
-  meta = with lib; {
-    description = "Collection of functions to generate hashes for signing on Ethereum";
-    homepage = "https://github.com/rmeissner/py-eth-sig-utils";
-    license = licenses.mit;
-    maintainers = [ ];
-    # TODO: upstream is stale and doesn't not work with the new `eth-abi` package any more.
-    broken = true;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 6e6e1d7f3160..a9770ef24527 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -562,6 +562,7 @@ mapAliases {
   pwndbg = throw "'pwndbg' has been removed due to dependency version incompatibilities that are infeasible to maintain in nixpkgs. Use the downstream flake that pwndbg provides instead: https://github.com/pwndbg/pwndbg"; # Added 2025-02-09
   pxml = throw "pxml was removed, because it was disabled on all python version since 3.8 and last updated in 2020."; # added 2024-05-13
   py3to2 = throw "py3to2 is unmaintained and source is no longer available"; # added 2024-10-23
+  py-eth-sig-utils = throw "py-eth-sig-utils has been removed because it has been marked as broken since at least November 2024."; # Added 2025-10-04
   pypcap = throw "pypcap has been removed because it is broken and unmaintained upstream."; # added 2025-06-18
   pytedee-async = aiotedee; # added 2025-07-06
   pytricia = throw "pytricia has been removed, since it is unmaintained"; # added 2025-05-25
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b290465a08da..69b61f580320 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12447,8 +12447,6 @@ self: super: with self; {
 
   py-ecc = callPackage ../development/python-modules/py-ecc { };
 
-  py-eth-sig-utils = callPackage ../development/python-modules/py-eth-sig-utils { };
-
   py-evm = callPackage ../development/python-modules/py-evm { };
 
   py-expression-eval = callPackage ../development/python-modules/py-expression-eval { };