diff --git a/pkgs/applications/graphics/mypaint/default.nix b/pkgs/applications/graphics/mypaint/default.nix
index 7b83bdec8c6b..b93b4794db81 100644
--- a/pkgs/applications/graphics/mypaint/default.nix
+++ b/pkgs/applications/graphics/mypaint/default.nix
@@ -1,5 +1,6 @@
 { lib
 , fetchFromGitHub
+, fetchpatch
 , gtk3
 , gettext
 , json_c
@@ -31,6 +32,15 @@ in buildPythonApplication rec {
     fetchSubmodules = true;
   };
 
+  patches = [
+    # Fix build due to setuptools issue.
+    # https://github.com/mypaint/mypaint/pull/1183
+    (fetchpatch {
+      url = "https://github.com/mypaint/mypaint/commit/423950bec96d6057eac70442de577364d784a847.patch";
+      sha256 = "OxJJOi20bFMRibL59zx6svtMrkgeMYyEvbdSXbZHqpc=";
+    })
+  ];
+
   nativeBuildInputs = [
     gettext
     pkg-config