diff --git a/pkgs/development/tools/misc/nrfutil/default.nix b/pkgs/development/tools/misc/nrfutil/default.nix
index 848afb5b2ca8..7ffd92451bf5 100644
--- a/pkgs/development/tools/misc/nrfutil/default.nix
+++ b/pkgs/development/tools/misc/nrfutil/default.nix
@@ -68,5 +68,7 @@ buildPythonApplication rec {
     license = licenses.unfreeRedistributable;
     platforms = platforms.unix;
     maintainers = with maintainers; [ gebner ];
+    # libusb1 1.9.3 uses setuptools' 2to3 translation feature, which has been removed in setuptools 58
+    broken = true;
   };
 }