diff --git a/pkgs/development/python-modules/ctranslate2/default.nix b/pkgs/development/python-modules/ctranslate2/default.nix
index 210d7aaacf02..d1a56041f07b 100644
--- a/pkgs/development/python-modules/ctranslate2/default.nix
+++ b/pkgs/development/python-modules/ctranslate2/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
 
   # build-system
@@ -59,6 +60,11 @@ buildPythonPackage rec {
     export HOME=$TMPDIR
   '';
 
+  disabledTests = lib.optionals stdenv.hostPlatform.isDarwin [
+    # Fatal Python error: Aborted
+    "test_invalid_model_path"
+  ];
+
   disabledTestPaths = [
     # TODO: ModuleNotFoundError: No module named 'opennmt'
     "tests/test_opennmt_tf.py"