diff --git a/pkgs/development/libraries/ctranslate2/default.nix b/pkgs/by-name/ct/ctranslate2/package.nix
similarity index 62%
rename from pkgs/development/libraries/ctranslate2/default.nix
rename to pkgs/by-name/ct/ctranslate2/package.nix
index 8524bb3e16ce..aaa3cbb13e27 100644
--- a/pkgs/development/libraries/ctranslate2/default.nix
+++ b/pkgs/by-name/ct/ctranslate2/package.nix
@@ -1,13 +1,14 @@
 {
   lib,
   stdenv,
+  config,
   fetchFromGitHub,
   cmake,
   llvmPackages, # openmp
   withMkl ? false,
   mkl,
-  withCUDA ? false,
-  withCuDNN ? false,
+  withCUDA ? config.cudaSupport,
+  withCuDNN ? withCUDA && (cudaPackages ? cudnn),
   cudaPackages,
   # Enabling both withOneDNN and withOpenblas is broken
   # https://github.com/OpenNMT/CTranslate2/issues/1294
@@ -23,21 +24,33 @@
 }:
 
 let
-  cmakeBool = b: if b then "ON" else "OFF";
   stdenv' = if withCUDA then cudaPackages.backendStdenv else stdenv;
 in
-stdenv'.mkDerivation rec {
+stdenv'.mkDerivation (finalAttrs: {
   pname = "ctranslate2";
   version = "4.6.0";
 
   src = fetchFromGitHub {
     owner = "OpenNMT";
     repo = "CTranslate2";
-    rev = "v${version}";
-    hash = "sha256-EM2kunqtxo0BTIzrEomfaRsdav7sx6QEOhjDtjjSoYY=";
+    tag = "v${finalAttrs.version}";
     fetchSubmodules = true;
+    hash = "sha256-EM2kunqtxo0BTIzrEomfaRsdav7sx6QEOhjDtjjSoYY=";
   };
 
+  # Fix CMake 4 compatibility
+  postPatch = ''
+    substituteInPlace third_party/cpu_features/CMakeLists.txt \
+      --replace-fail \
+        'cmake_minimum_required(VERSION 3.0)' \
+        'cmake_minimum_required(VERSION 3.10)'
+
+    substituteInPlace third_party/ruy/third_party/cpuinfo/deps/clog/CMakeLists.txt \
+      --replace-fail \
+        'CMAKE_MINIMUM_REQUIRED(VERSION 3.1 FATAL_ERROR)' \
+        'CMAKE_MINIMUM_REQUIRED(VERSION 3.10 FATAL_ERROR)'
+  '';
+
   nativeBuildInputs = [
     cmake
   ]
@@ -49,15 +62,17 @@ stdenv'.mkDerivation rec {
     # https://opennmt.net/CTranslate2/installation.html#build-options
     # https://github.com/OpenNMT/CTranslate2/blob/54810350e662ebdb01ecbf8e4a746f02aeff1dd7/python/tools/prepare_build_environment_linux.sh#L53
     # https://github.com/OpenNMT/CTranslate2/blob/59d223abcc7e636c1c2956e62482bc3299cc7766/python/tools/prepare_build_environment_macos.sh#L12
-    "-DOPENMP_RUNTIME=COMP"
-    "-DWITH_CUDA=${cmakeBool withCUDA}"
-    "-DWITH_CUDNN=${cmakeBool withCuDNN}"
-    "-DWITH_DNNL=${cmakeBool withOneDNN}"
-    "-DWITH_OPENBLAS=${cmakeBool withOpenblas}"
-    "-DWITH_RUY=${cmakeBool withRuy}"
-    "-DWITH_MKL=${cmakeBool withMkl}"
+    (lib.cmakeFeature "OPENMP_RUNTIME" "COMP")
+    (lib.cmakeBool "WITH_CUDA" withCUDA)
+    (lib.cmakeBool "WITH_CUDNN" withCuDNN)
+    (lib.cmakeBool "WITH_DNNL" withOneDNN)
+    (lib.cmakeBool "WITH_OPENBLAS" withOpenblas)
+    (lib.cmakeBool "WITH_RUY" withRuy)
+    (lib.cmakeBool "WITH_MKL" withMkl)
   ]
-  ++ lib.optional stdenv.hostPlatform.isDarwin "-DWITH_ACCELERATE=ON";
+  ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    (lib.cmakeBool "WITH_ACCELERATE" true)
+  ];
 
   buildInputs =
     lib.optionals withMkl [
@@ -89,16 +104,16 @@ stdenv'.mkDerivation rec {
       ;
   };
 
-  meta = with lib; {
+  meta = {
     description = "Fast inference engine for Transformer models";
     mainProgram = "ct2-translator";
     homepage = "https://github.com/OpenNMT/CTranslate2";
-    changelog = "https://github.com/OpenNMT/CTranslate2/blob/${src.rev}/CHANGELOG.md";
-    license = licenses.mit;
-    maintainers = with maintainers; [
+    changelog = "https://github.com/OpenNMT/CTranslate2/blob/${finalAttrs.src.tag}/CHANGELOG.md";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [
       hexa
       misuzu
     ];
     broken = !(withCuDNN -> withCUDA);
   };
-}
+})
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 31dc02845bf9..798adf664c28 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -7131,12 +7131,6 @@ with pkgs;
 
   inherit (cosmopolitan) cosmocc;
 
-  ctranslate2 = callPackage ../development/libraries/ctranslate2 rec {
-    withCUDA = pkgs.config.cudaSupport;
-    withCuDNN = withCUDA && (cudaPackages ? cudnn);
-    cudaPackages = pkgs.cudaPackages;
-  };
-
   ustream-ssl = callPackage ../development/libraries/ustream-ssl { ssl_implementation = openssl; };
 
   ustream-ssl-wolfssl = callPackage ../development/libraries/ustream-ssl {