diff --git a/pkgs/tools/security/ghidra/build-extension.nix b/pkgs/tools/security/ghidra/build-extension.nix
index a677879f8a39..b6bec2073ca1 100644
--- a/pkgs/tools/security/ghidra/build-extension.nix
+++ b/pkgs/tools/security/ghidra/build-extension.nix
@@ -58,6 +58,11 @@ let
             mkdir -p $out/lib/ghidra/Ghidra/Extensions
             unzip -d $out/lib/ghidra/Ghidra/Extensions dist/*.zip
 
+            # Prevent attempted creation of plugin lock files in the Nix store.
+            for i in $out/lib/ghidra/Ghidra/Extensions/*; do
+              touch "$i/.dbDirLock"
+            done
+
             runHook postInstall
           '';
 
diff --git a/pkgs/tools/security/ghidra/with-extensions.nix b/pkgs/tools/security/ghidra/with-extensions.nix
index e1ddfed4a06a..80276704ac78 100644
--- a/pkgs/tools/security/ghidra/with-extensions.nix
+++ b/pkgs/tools/security/ghidra/with-extensions.nix
@@ -30,6 +30,9 @@ let
       ] ++ lib.optional stdenv.hostPlatform.isDarwin desktopToDarwinBundle;
       postBuild =
         ''
+          # Prevent attempted creation of plugin lock files in the Nix store.
+          touch $out/lib/ghidra/Ghidra/.dbDirLock
+
           makeWrapper '${ghidra}/bin/ghidra' "$out/bin/ghidra" \
             --set NIX_GHIDRAHOME "$out/lib/ghidra/Ghidra"
           makeWrapper '${ghidra}/bin/ghidra-analyzeHeadless' "$out/bin/ghidra-analyzeHeadless" \