diff --git a/doc/languages-frameworks/python.section.md b/doc/languages-frameworks/python.section.md
index eeecb640d966..957037b95f4f 100644
--- a/doc/languages-frameworks/python.section.md
+++ b/doc/languages-frameworks/python.section.md
@@ -48,7 +48,6 @@ Based on the packages defined in `pkgs/top-level/python-packages.nix` an
 attribute set is created for each available Python interpreter. The available
 sets are
 
-* `pkgs.python27Packages`
 * `pkgs.python3Packages`
 * `pkgs.python311Packages`
 * `pkgs.python312Packages`
@@ -60,9 +59,7 @@ sets are
 
 and the aliases
 
-* `pkgs.python2Packages` pointing to `pkgs.python27Packages`
 * `pkgs.python3Packages` pointing to `pkgs.python313Packages`
-* `pkgs.pythonPackages` pointing to `pkgs.python2Packages`
 * `pkgs.pypy2Packages` pointing to `pkgs.pypy27Packages`
 * `pkgs.pypy3Packages` pointing to `pkgs.pypy310Packages`
 * `pkgs.pypyPackages` pointing to `pkgs.pypy2Packages`
@@ -573,9 +570,6 @@ In contrast to [`python.buildEnv`](#python.buildenv-function), [`python.withPack
 more advanced options such as `ignoreCollisions = true` or `postBuild`. If you
 need them, you have to use [`python.buildEnv`](#python.buildenv-function).
 
-Python 2 namespace packages may provide `__init__.py` that collide. In that case
-[`python.buildEnv`](#python.buildenv-function) should be used with `ignoreCollisions = true`.
-
 #### Setup hooks {#setup-hooks}
 
 The following are setup hooks specifically for Python packages. Most of these
@@ -627,10 +621,9 @@ buildPythonPackage.override { stdenv = customStdenv; } {
 
 Several versions of the Python interpreter are available on Nix, as well as a
 high amount of packages. The attribute `python3` refers to the default
-interpreter, which is currently CPython 3.13. The attribute `python` refers to
-CPython 2.7 for backwards compatibility. It is also possible to refer to
-specific versions, e.g., `python313` refers to CPython 3.13, and `pypy` refers to
-the default PyPy interpreter.
+interpreter, which is currently CPython 3.13. It is also possible to refer to
+specific versions, e.g., `python313` refers to CPython 3.13, and `pypy` refers
+to the default PyPy interpreter.
 
 Python is used a lot, and in different ways. This affects also how it is
 packaged. In the case of Python on Nix, an important distinction is made between
@@ -1910,9 +1903,8 @@ pkgs.mkShell rec {
 }
 ```
 
-In case the supplied venvShellHook is insufficient, or when Python 2 support is
-needed, you can define your own shell hook and adapt to your needs like in the
-following example:
+In case the supplied venvShellHook is insufficient, you can define your own
+shell hook and adapt to your needs like in the following example:
 
 ```nix
 with import <nixpkgs> { };
@@ -1925,8 +1917,6 @@ pkgs.mkShell rec {
   name = "impurePythonEnv";
   buildInputs = [
     pythonPackages.python
-    # Needed when using python 2.7
-    # pythonPackages.virtualenv
     # ...
   ];
 
@@ -1939,8 +1929,6 @@ pkgs.mkShell rec {
       echo "Skipping venv creation, '${venvDir}' already exists"
     else
       echo "Creating new venv environment in path: '${venvDir}'"
-      # Note that the module venv was only introduced in python 3, so for 2.7
-      # this needs to be replaced with a call to virtualenv
       ${pythonPackages.python.interpreter} -m venv "${venvDir}"
     fi
 
diff --git a/nixos/doc/manual/release-notes/rl-2611.section.md b/nixos/doc/manual/release-notes/rl-2611.section.md
index f029f3e9032f..798e204a578d 100644
--- a/nixos/doc/manual/release-notes/rl-2611.section.md
+++ b/nixos/doc/manual/release-notes/rl-2611.section.md
@@ -18,6 +18,8 @@
 
 - `boot.vesa` has been removed. It was deprecated in 2020 because Xorg now works better with kernel modesetting. If you still need the legacy VESA 800x600 fallback, set `boot.kernelParams = [ "vga=0x317" "nomodeset" ];` directly.
 
+- Python 2 has been removed from the top-level package set, as it is long past end-of-life. The `python2`, `python27`, `python2Full`, `python27Full`, `python2Packages`, and `python27Packages` attributes, along with the legacy `python`, `pythonFull`, and `pythonPackages` aliases, now throw an error directing you to `python3`. The `isPy2` and `isPy27` package flags have been removed accordingly. The only remaining Python 2 interpreter is vendored inside the `resholve` package for its `oil` dependency and is not exposed for general use.
+
 ## Other Notable Changes {#sec-release-26.11-notable-changes}
 
 <!-- To avoid merge conflicts, consider adding your item at an arbitrary place in the list instead. -->
diff --git a/pkgs/by-name/re/replacement/package.nix b/pkgs/by-name/re/replacement/package.nix
index 97c24a44a4f8..0802d55315b4 100644
--- a/pkgs/by-name/re/replacement/package.nix
+++ b/pkgs/by-name/re/replacement/package.nix
@@ -9,8 +9,6 @@ python3Packages.buildPythonApplication (finalAttrs: {
   version = "0.4.4";
   pyproject = true;
 
-  disabled = python3Packages.isPy27;
-
   src = fetchFromGitHub {
     owner = "siriobalmelli";
     repo = "replacement";
diff --git a/pkgs/development/interpreters/python/cpython/docs/2.7-html.nix b/pkgs/development/interpreters/python/cpython/docs/2.7-html.nix
deleted file mode 100644
index e706fc0b9125..000000000000
--- a/pkgs/development/interpreters/python/cpython/docs/2.7-html.nix
+++ /dev/null
@@ -1,24 +0,0 @@
-# This file was generated and will be overwritten by ./generate.sh
-
-{
-  stdenv,
-  lib,
-  fetchurl,
-}:
-
-stdenv.mkDerivation {
-  pname = "python27-docs-html";
-  version = "2.7.18";
-
-  src = fetchurl {
-    url = "https://www.python.org/ftp/python/doc/2.7.18/python-2.7.18-docs-html.tar.bz2";
-    sha256 = "03igxwpqc2lvzspnj78zz1prnmfwwj00jbvh1wsxvb0wayd5wi10";
-  };
-  installPhase = ''
-    mkdir -p $out/share/doc/python27
-    cp -R ./ $out/share/doc/python27/html
-  '';
-  meta = {
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-a4.nix b/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-a4.nix
deleted file mode 100644
index 31d8a2fe337f..000000000000
--- a/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-a4.nix
+++ /dev/null
@@ -1,24 +0,0 @@
-# This file was generated and will be overwritten by ./generate.sh
-
-{
-  stdenv,
-  lib,
-  fetchurl,
-}:
-
-stdenv.mkDerivation {
-  pname = "python27-docs-pdf-a4";
-  version = "2.7.18";
-
-  src = fetchurl {
-    url = "https://www.python.org/ftp/python/doc/2.7.18/python-2.7.18-docs-pdf-a4.tar.bz2";
-    sha256 = "0rxb2fpxwivjpk5wi2pl1fqibr4khf9s0yq6a49k9b4awi9nkb6v";
-  };
-  installPhase = ''
-    mkdir -p $out/share/doc/python27
-    cp -R ./ $out/share/doc/python27/pdf-a4
-  '';
-  meta = {
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-letter.nix b/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-letter.nix
deleted file mode 100644
index 7ee205efc947..000000000000
--- a/pkgs/development/interpreters/python/cpython/docs/2.7-pdf-letter.nix
+++ /dev/null
@@ -1,24 +0,0 @@
-# This file was generated and will be overwritten by ./generate.sh
-
-{
-  stdenv,
-  lib,
-  fetchurl,
-}:
-
-stdenv.mkDerivation {
-  pname = "python27-docs-pdf-letter";
-  version = "2.7.18";
-
-  src = fetchurl {
-    url = "https://www.python.org/ftp/python/doc/2.7.18/python-2.7.18-docs-pdf-letter.tar.bz2";
-    sha256 = "07hbqvrdlq01cb95r1574bxqqhiqbkj4f92wzlq4d6dq1l272nan";
-  };
-  installPhase = ''
-    mkdir -p $out/share/doc/python27
-    cp -R ./ $out/share/doc/python27/pdf-letter
-  '';
-  meta = {
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/development/interpreters/python/cpython/docs/2.7-text.nix b/pkgs/development/interpreters/python/cpython/docs/2.7-text.nix
deleted file mode 100644
index 8caea548ffa0..000000000000
--- a/pkgs/development/interpreters/python/cpython/docs/2.7-text.nix
+++ /dev/null
@@ -1,24 +0,0 @@
-# This file was generated and will be overwritten by ./generate.sh
-
-{
-  stdenv,
-  lib,
-  fetchurl,
-}:
-
-stdenv.mkDerivation {
-  pname = "python27-docs-text";
-  version = "2.7.18";
-
-  src = fetchurl {
-    url = "https://www.python.org/ftp/python/doc/2.7.18/python-2.7.18-docs-text.tar.bz2";
-    sha256 = "1wj7mxs52kp5lmn5mvv574sygkfnk00kbz9ya9c03yfq5dd5nvy8";
-  };
-  installPhase = ''
-    mkdir -p $out/share/doc/python27
-    cp -R ./ $out/share/doc/python27/text
-  '';
-  meta = {
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/development/interpreters/python/cpython/docs/default.nix b/pkgs/development/interpreters/python/cpython/docs/default.nix
index a2d6a35ba8b5..d5cc62a92120 100644
--- a/pkgs/development/interpreters/python/cpython/docs/default.nix
+++ b/pkgs/development/interpreters/python/cpython/docs/default.nix
@@ -8,36 +8,24 @@ let
   pythonDocs = {
     html = {
       recurseForDerivations = true;
-      python27 = import ./2.7-html.nix {
-        inherit stdenv fetchurl lib;
-      };
       python310 = import ./3.10-html.nix {
         inherit stdenv fetchurl lib;
       };
     };
     pdf_a4 = {
       recurseForDerivations = true;
-      python27 = import ./2.7-pdf-a4.nix {
-        inherit stdenv fetchurl lib;
-      };
       python310 = import ./3.10-pdf-a4.nix {
         inherit stdenv fetchurl lib;
       };
     };
     pdf_letter = {
       recurseForDerivations = true;
-      python27 = import ./2.7-pdf-letter.nix {
-        inherit stdenv fetchurl lib;
-      };
       python310 = import ./3.10-pdf-letter.nix {
         inherit stdenv fetchurl lib;
       };
     };
     text = {
       recurseForDerivations = true;
-      python27 = import ./2.7-text.nix {
-        inherit stdenv fetchurl lib;
-      };
       python310 = import ./3.10-text.nix {
         inherit stdenv fetchurl lib;
       };
diff --git a/pkgs/development/interpreters/python/default.nix b/pkgs/development/interpreters/python/default.nix
index 11a150d78506..d87e115892b8 100644
--- a/pkgs/development/interpreters/python/default.nix
+++ b/pkgs/development/interpreters/python/default.nix
@@ -30,18 +30,6 @@
   in
   {
 
-    python27 = callPackage ./cpython/2.7 {
-      self = __splicedPackages.python27;
-      sourceVersion = {
-        major = "2";
-        minor = "7";
-        patch = "18";
-        suffix = ".12"; # ActiveState's Python 2 extended support
-      };
-      hash = "sha256-RuEgfpags9wJm9Xe0daotqUx4knABEUc7DvtgnQXEfE=";
-      inherit passthruFun;
-    };
-
     python311 = callPackage ./cpython {
       self = __splicedPackages.python311;
       sourceVersion = {
diff --git a/pkgs/development/interpreters/python/passthrufun.nix b/pkgs/development/interpreters/python/passthrufun.nix
index e302e9b6bdc0..005ba62ba742 100644
--- a/pkgs/development/interpreters/python/passthrufun.nix
+++ b/pkgs/development/interpreters/python/passthrufun.nix
@@ -79,7 +79,7 @@ let
             keep = self: hooks self { };
             optionalExtensions = cond: as: lib.optionals cond as;
             pythonExtension = import ../../../top-level/python-packages.nix;
-            python2Extension = import ../../../top-level/python2-packages.nix;
+            python2Extension = import ../../misc/resholve/python2-packages.nix;
             extensions = lib.composeManyExtensions (
               [
                 hooks
@@ -109,12 +109,10 @@ let
     );
 in
 rec {
-  isPy27 = pythonVersion == "2.7";
   isPy311 = pythonVersion == "3.11";
   isPy312 = pythonVersion == "3.12";
   isPy313 = pythonVersion == "3.13";
   isPy314 = pythonVersion == "3.14";
-  isPy2 = lib.strings.substring 0 1 pythonVersion == "2";
   isPy3 = lib.strings.substring 0 1 pythonVersion == "3";
   isPy3k = isPy3;
   isPyPy = lib.hasInfix "pypy" interpreter;
diff --git a/pkgs/development/interpreters/python/python-packages-base.nix b/pkgs/development/interpreters/python/python-packages-base.nix
index aeb5582e4c8b..68b10dfc8c6a 100644
--- a/pkgs/development/interpreters/python/python-packages-base.nix
+++ b/pkgs/development/interpreters/python/python-packages-base.nix
@@ -102,7 +102,11 @@ let
     );
 
   mkPythonDerivation =
-    if python.isPy3k then ./mk-python-derivation.nix else ./python2/mk-python-derivation.nix;
+    if python.isPy3k then
+      ./mk-python-derivation.nix
+    else
+      # Python 2 build infrastructure lives with its only consumers (resholve, pypy27).
+      ../../misc/resholve/python2/mk-python-derivation.nix;
 
   buildPythonPackage = makeOverridablePythonPackage (
     overrideStdenvCompat (
@@ -186,7 +190,6 @@ in
 {
   inherit lib pkgs stdenv;
   inherit (python.passthru)
-    isPy27
     isPy311
     isPy312
     isPy313
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.5.2-ctypes-util-find_library.patch b/pkgs/development/misc/resholve/cpython-2.7/2.5.2-ctypes-util-find_library.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.5.2-ctypes-util-find_library.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.5.2-ctypes-util-find_library.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.5.2-tkinter-x11.patch b/pkgs/development/misc/resholve/cpython-2.7/2.5.2-tkinter-x11.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.5.2-tkinter-x11.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.5.2-tkinter-x11.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.6.2-ssl-threads.patch b/pkgs/development/misc/resholve/cpython-2.7/2.6.2-ssl-threads.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.6.2-ssl-threads.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.6.2-ssl-threads.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.6.5-FD_SETSIZE.patch b/pkgs/development/misc/resholve/cpython-2.7/2.6.5-FD_SETSIZE.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.6.5-FD_SETSIZE.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.6.5-FD_SETSIZE.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.6.5-export-PySignal_SetWakeupFd.patch b/pkgs/development/misc/resholve/cpython-2.7/2.6.5-export-PySignal_SetWakeupFd.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.6.5-export-PySignal_SetWakeupFd.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.6.5-export-PySignal_SetWakeupFd.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.6.5-ncurses-abi6.patch b/pkgs/development/misc/resholve/cpython-2.7/2.6.5-ncurses-abi6.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.6.5-ncurses-abi6.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.6.5-ncurses-abi6.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.7.3-dbm.patch b/pkgs/development/misc/resholve/cpython-2.7/2.7.3-dbm.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.7.3-dbm.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.7.3-dbm.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.7.3-dylib.patch b/pkgs/development/misc/resholve/cpython-2.7/2.7.3-dylib.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.7.3-dylib.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.7.3-dylib.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.7.3-getpath-exe-extension.patch b/pkgs/development/misc/resholve/cpython-2.7/2.7.3-getpath-exe-extension.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.7.3-getpath-exe-extension.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.7.3-getpath-exe-extension.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/2.7.3-no-libm.patch b/pkgs/development/misc/resholve/cpython-2.7/2.7.3-no-libm.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/2.7.3-no-libm.patch
rename to pkgs/development/misc/resholve/cpython-2.7/2.7.3-no-libm.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/atomic_pyc.patch b/pkgs/development/misc/resholve/cpython-2.7/atomic_pyc.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/atomic_pyc.patch
rename to pkgs/development/misc/resholve/cpython-2.7/atomic_pyc.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/cross-compile.patch b/pkgs/development/misc/resholve/cpython-2.7/cross-compile.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/cross-compile.patch
rename to pkgs/development/misc/resholve/cpython-2.7/cross-compile.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/default.nix b/pkgs/development/misc/resholve/cpython-2.7/default.nix
similarity index 99%
rename from pkgs/development/interpreters/python/cpython/2.7/default.nix
rename to pkgs/development/misc/resholve/cpython-2.7/default.nix
index 9f3d064ceeb1..e68c988ca0b4 100644
--- a/pkgs/development/interpreters/python/cpython/2.7/default.nix
+++ b/pkgs/development/misc/resholve/cpython-2.7/default.nix
@@ -146,7 +146,7 @@ let
     # It does break aarch64-darwin, which we do support. See:
     # * https://bugs.python.org/issue35523
     # * https://github.com/python/cpython/commit/e6b247c8e524
-    ../3.7/no-win64-workaround.patch
+    ./no-win64-workaround.patch
 
     # fix openssl detection by reverting irrelevant change for us, to enable hashlib which is required by pip
     (fetchpatch {
@@ -378,7 +378,7 @@ stdenv.mkDerivation (
 
     postFixup = ''
       # Include a sitecustomize.py file. Note it causes an error when it's in postInstall with 2.7.
-      cp ${../../sitecustomize.py} $out/${sitePackages}/sitecustomize.py
+      cp ${../../../interpreters/python/sitecustomize.py} $out/${sitePackages}/sitecustomize.py
     ''
     + lib.optionalString strip2to3 ''
       rm -R $out/bin/2to3 $out/lib/python*/lib2to3
diff --git a/pkgs/development/interpreters/python/cpython/2.7/deterministic-build.patch b/pkgs/development/misc/resholve/cpython-2.7/deterministic-build.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/deterministic-build.patch
rename to pkgs/development/misc/resholve/cpython-2.7/deterministic-build.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/find_library-gcc10.patch b/pkgs/development/misc/resholve/cpython-2.7/find_library-gcc10.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/find_library-gcc10.patch
rename to pkgs/development/misc/resholve/cpython-2.7/find_library-gcc10.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/nix-store-mtime.patch b/pkgs/development/misc/resholve/cpython-2.7/nix-store-mtime.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/nix-store-mtime.patch
rename to pkgs/development/misc/resholve/cpython-2.7/nix-store-mtime.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/no-ldconfig.patch b/pkgs/development/misc/resholve/cpython-2.7/no-ldconfig.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/no-ldconfig.patch
rename to pkgs/development/misc/resholve/cpython-2.7/no-ldconfig.patch
diff --git a/pkgs/development/interpreters/python/cpython/3.7/no-win64-workaround.patch b/pkgs/development/misc/resholve/cpython-2.7/no-win64-workaround.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/3.7/no-win64-workaround.patch
rename to pkgs/development/misc/resholve/cpython-2.7/no-win64-workaround.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/profile-task.patch b/pkgs/development/misc/resholve/cpython-2.7/profile-task.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/profile-task.patch
rename to pkgs/development/misc/resholve/cpython-2.7/profile-task.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/python-2.7-distutils-C++.patch b/pkgs/development/misc/resholve/cpython-2.7/python-2.7-distutils-C++.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/python-2.7-distutils-C++.patch
rename to pkgs/development/misc/resholve/cpython-2.7/python-2.7-distutils-C++.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/search-path.patch b/pkgs/development/misc/resholve/cpython-2.7/search-path.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/search-path.patch
rename to pkgs/development/misc/resholve/cpython-2.7/search-path.patch
diff --git a/pkgs/development/interpreters/python/cpython/2.7/use-correct-tcl-tk-on-darwin.patch b/pkgs/development/misc/resholve/cpython-2.7/use-correct-tcl-tk-on-darwin.patch
similarity index 100%
rename from pkgs/development/interpreters/python/cpython/2.7/use-correct-tcl-tk-on-darwin.patch
rename to pkgs/development/misc/resholve/cpython-2.7/use-correct-tcl-tk-on-darwin.patch
diff --git a/pkgs/development/misc/resholve/default.nix b/pkgs/development/misc/resholve/default.nix
index a8061d19fe0d..1582b64fc339 100644
--- a/pkgs/development/misc/resholve/default.nix
+++ b/pkgs/development/misc/resholve/default.nix
@@ -12,35 +12,8 @@ let
         knownVulnerabilities = [ ];
       };
     });
-  # We are removing `meta.knownVulnerabilities` from `python27`,
-  # and setting it in `resholve` itself.
-  python27' = (removeKnownVulnerabilities pkgsBuildHost.python27).override {
-    self = python27';
-    pkgsBuildHost = pkgsBuildHost // {
-      python27 = python27';
-    };
-    # strip down that python version as much as possible
-    openssl = null;
-    bzip2 = null;
-    readline = null;
-    ncurses = null;
-    gdbm = null;
-    sqlite = null;
-    rebuildBytecode = false;
-    stripBytecode = true;
-    strip2to3 = true;
-    stripConfig = true;
-    stripIdlelib = true;
-    stripTests = true;
-    enableOptimizations = false;
-    packageOverrides = final: prev: {
-      pip = removeKnownVulnerabilities prev.pip;
-      setuptools = removeKnownVulnerabilities prev.setuptools;
-    };
-  };
-  callPackage = lib.callPackageWith (pkgsBuildHost // { python27 = python27'; });
+  callPackage = lib.callPackageWith pkgsBuildHost;
   source = callPackage ./source.nix { };
-  deps = callPackage ./deps.nix { };
   # not exposed in all-packages
   resholveBuildTimeOnly = removeKnownVulnerabilities resholve;
 in
@@ -49,8 +22,6 @@ rec {
   resholve = (
     callPackage ./resholve.nix {
       inherit (source) rSrc version;
-      inherit (deps.oil) oildev;
-      inherit (deps) configargparse;
       inherit resholve-utils;
       # used only in tests
       resholve = resholveBuildTimeOnly;
diff --git a/pkgs/development/misc/resholve/deps.nix b/pkgs/development/misc/resholve/deps.nix
deleted file mode 100644
index e96e049528c1..000000000000
--- a/pkgs/development/misc/resholve/deps.nix
+++ /dev/null
@@ -1,78 +0,0 @@
-{
-  lib,
-  callPackage,
-  fetchFromGitHub,
-  python27,
-  fetchPypi,
-  ...
-}:
-
-/*
-  Notes on specific dependencies:
-  - if/when python2.7 is removed from nixpkgs, this may need to figure
-  out how to build oil's vendored python2
-*/
-
-rec {
-  oil = callPackage ./oildev.nix {
-    inherit python27;
-    inherit six;
-    inherit typing;
-  };
-  configargparse = python27.pkgs.buildPythonPackage rec {
-    pname = "configargparse";
-    version = "1.5.3";
-    format = "setuptools";
-
-    src = fetchFromGitHub {
-      owner = "bw2";
-      repo = "ConfigArgParse";
-      rev = "v${version}";
-      sha256 = "1dsai4bilkp2biy9swfdx2z0k4akw4lpvx12flmk00r80hzgbglz";
-    };
-
-    doCheck = false;
-
-    pythonImportsCheck = [ "configargparse" ];
-
-    meta = {
-      description = "Drop-in replacement for argparse";
-      homepage = "https://github.com/bw2/ConfigArgParse";
-      license = lib.licenses.mit;
-    };
-  };
-  six = python27.pkgs.buildPythonPackage rec {
-    pname = "six";
-    version = "1.16.0";
-
-    src = fetchPypi {
-      inherit pname version;
-      sha256 = "1e61c37477a1626458e36f7b1d82aa5c9b094fa4802892072e49de9c60c4c926";
-    };
-
-    doCheck = false;
-
-    meta = {
-      description = "Python 2 and 3 compatibility library";
-      homepage = "https://pypi.org/project/six/";
-      license = lib.licenses.mit;
-    };
-  };
-  typing = python27.pkgs.buildPythonPackage rec {
-    pname = "typing";
-    version = "3.10.0.0";
-
-    src = fetchPypi {
-      inherit pname version;
-      sha256 = "13b4ad211f54ddbf93e5901a9967b1e07720c1d1b78d596ac6a439641aa1b130";
-    };
-
-    doCheck = false;
-
-    meta = {
-      description = "Backport of typing module to Python versions older than 3.5";
-      homepage = "https://docs.python.org/3/library/typing.html";
-      license = lib.licenses.psfl;
-    };
-  };
-}
diff --git a/pkgs/development/misc/resholve/oildev.nix b/pkgs/development/misc/resholve/oildev.nix
deleted file mode 100644
index 7eb6314a2edc..000000000000
--- a/pkgs/development/misc/resholve/oildev.nix
+++ /dev/null
@@ -1,121 +0,0 @@
-{
-  lib,
-  stdenv,
-  python27,
-  callPackage,
-  fetchFromGitHub,
-  makeWrapper,
-  re2c,
-  # oil deps
-  glibcLocales,
-  file,
-  six,
-  typing,
-}:
-
-{
-  /*
-    Upstream isn't interested in packaging this as a library
-    (or accepting all of the patches we need to do so).
-    This creates one without disturbing upstream too much.
-  */
-  oildev = python27.pkgs.buildPythonPackage rec {
-    pname = "oildev-unstable";
-    version = "2024-02-26";
-    format = "setuptools";
-
-    src = fetchFromGitHub {
-      owner = "oilshell";
-      repo = "oil";
-      # rev == present HEAD of release/0.20.0
-      rev = "f730c79e2dcde4bc08e85a718951cfa42102bd01";
-      hash = "sha256-HBj3Izh1gD63EzbgZ/9If5vihR5L2HhnyCyMah6rMg4=";
-
-      /*
-        It's not critical to drop most of these; the primary target is
-        the vendored fork of Python-2.7.13, which is ~ 55M and over 3200
-        files, dozens of which get interpreter script patches in fixup.
-
-        Note: -f is necessary to keep it from being a pain to update
-        hash on rev updates. Command will fail w/o and not print hash.
-      */
-      postFetch = ''
-        rm -rf $out/{Python-2.7.13,metrics,py-yajl,rfc,gold,web,testdata,services,demo}
-      '';
-    };
-
-    # patch to support a python package, pass tests on macOS, drop deps, etc.
-    patchSrc = fetchFromGitHub {
-      owner = "abathur";
-      repo = "nix-py-dev-oil";
-      rev = "v0.20.0.0";
-      hash = "sha256-qoA54rnzAdnFZ3k4kRzQWEdgtEjraCT5+NFw8AWnRDk=";
-    };
-
-    patches = [
-      "${patchSrc}/0001-add_setup_py.patch"
-      "${patchSrc}/0002-add_MANIFEST_in.patch"
-      "${patchSrc}/0006-disable_failing_libc_tests.patch"
-      "${patchSrc}/0007-namespace_via_init.patch"
-      "${patchSrc}/0009-avoid_nix_arch64_darwin_toolchain_bug.patch"
-      "${patchSrc}/0010-disable-line-input.patch"
-      "${patchSrc}/0011-disable-fanos.patch"
-      "${patchSrc}/0012-disable-doc-cmark.patch"
-      "${patchSrc}/0013-fix-pyverify.patch"
-      "${patchSrc}/0015-fix-compiled-extension-import-paths.patch"
-    ];
-
-    configureFlags = [
-      "--without-readline"
-    ];
-
-    nativeBuildInputs = [
-      re2c
-      file
-      makeWrapper
-    ];
-
-    propagatedBuildInputs = [
-      six
-      typing
-    ];
-
-    doCheck = true;
-
-    preBuild = ''
-      build/py.sh all
-    '';
-
-    postPatch = ''
-      patchShebangs asdl build core doctools frontend pyext oil_lang ysh
-      rm cpp/stdlib.h # keep modules from finding the wrong stdlib?
-      # work around hard parse failure documented in oilshell/oil#1468
-      substituteInPlace osh/cmd_parse.py --replace 'elif self.c_id == Id.Op_LParen' 'elif False'
-    '';
-
-    # See earlier note on glibcLocales TODO: verify needed?
-    LOCALE_ARCHIVE = lib.optionalString (
-      stdenv.buildPlatform.libc == "glibc"
-    ) "${glibcLocales}/lib/locale/locale-archive";
-
-    # not exhaustive; sample what resholve uses as a sanity check
-    pythonImportsCheck = [
-      "oil"
-      "oil.asdl"
-      "oil.core"
-      "oil.frontend"
-      "oil._devbuild"
-      "oil._devbuild.gen.id_kind_asdl"
-      "oil._devbuild.gen.syntax_asdl"
-      "oil.osh"
-      "oil.tools.ysh_ify"
-    ];
-
-    meta = {
-      license = with lib.licenses; [
-        psfl # Includes a portion of the python interpreter and standard library
-        asl20 # Licence for Oil itself
-      ];
-    };
-  };
-}
diff --git a/pkgs/development/python2-modules/bootstrapped-pip/default.nix b/pkgs/development/misc/resholve/python2-modules/bootstrapped-pip/default.nix
similarity index 100%
rename from pkgs/development/python2-modules/bootstrapped-pip/default.nix
rename to pkgs/development/misc/resholve/python2-modules/bootstrapped-pip/default.nix
diff --git a/pkgs/development/misc/resholve/python2-modules/configargparse/default.nix b/pkgs/development/misc/resholve/python2-modules/configargparse/default.nix
new file mode 100644
index 000000000000..b05dee7079c2
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-modules/configargparse/default.nix
@@ -0,0 +1,28 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+}:
+
+buildPythonPackage rec {
+  pname = "configargparse";
+  version = "1.5.3";
+  format = "setuptools";
+
+  src = fetchFromGitHub {
+    owner = "bw2";
+    repo = "ConfigArgParse";
+    rev = "v${version}";
+    sha256 = "1dsai4bilkp2biy9swfdx2z0k4akw4lpvx12flmk00r80hzgbglz";
+  };
+
+  doCheck = false;
+
+  pythonImportsCheck = [ "configargparse" ];
+
+  meta = {
+    description = "Drop-in replacement for argparse";
+    homepage = "https://github.com/bw2/ConfigArgParse";
+    license = lib.licenses.mit;
+  };
+}
diff --git a/pkgs/development/misc/resholve/python2-modules/oildev/default.nix b/pkgs/development/misc/resholve/python2-modules/oildev/default.nix
new file mode 100644
index 000000000000..e8cf4e5df6f2
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-modules/oildev/default.nix
@@ -0,0 +1,115 @@
+{
+  lib,
+  stdenv,
+  buildPythonPackage,
+  fetchFromGitHub,
+  makeWrapper,
+  re2c,
+  glibcLocales,
+  file,
+  six,
+  typing,
+}:
+
+# Upstream isn't interested in packaging this as a library
+# (or accepting all of the patches we need to do so).
+# This creates one without disturbing upstream too much.
+buildPythonPackage rec {
+  pname = "oildev-unstable";
+  version = "2024-02-26";
+  format = "setuptools";
+
+  src = fetchFromGitHub {
+    owner = "oilshell";
+    repo = "oil";
+    # rev == present HEAD of release/0.20.0
+    rev = "f730c79e2dcde4bc08e85a718951cfa42102bd01";
+    hash = "sha256-HBj3Izh1gD63EzbgZ/9If5vihR5L2HhnyCyMah6rMg4=";
+
+    /*
+      It's not critical to drop most of these; the primary target is
+      the vendored fork of Python-2.7.13, which is ~ 55M and over 3200
+      files, dozens of which get interpreter script patches in fixup.
+
+      Note: -f is necessary to keep it from being a pain to update
+      hash on rev updates. Command will fail w/o and not print hash.
+    */
+    postFetch = ''
+      rm -rf $out/{Python-2.7.13,metrics,py-yajl,rfc,gold,web,testdata,services,demo}
+    '';
+  };
+
+  # patch to support a python package, pass tests on macOS, drop deps, etc.
+  patchSrc = fetchFromGitHub {
+    owner = "abathur";
+    repo = "nix-py-dev-oil";
+    rev = "v0.20.0.0";
+    hash = "sha256-qoA54rnzAdnFZ3k4kRzQWEdgtEjraCT5+NFw8AWnRDk=";
+  };
+
+  patches = [
+    "${patchSrc}/0001-add_setup_py.patch"
+    "${patchSrc}/0002-add_MANIFEST_in.patch"
+    "${patchSrc}/0006-disable_failing_libc_tests.patch"
+    "${patchSrc}/0007-namespace_via_init.patch"
+    "${patchSrc}/0009-avoid_nix_arch64_darwin_toolchain_bug.patch"
+    "${patchSrc}/0010-disable-line-input.patch"
+    "${patchSrc}/0011-disable-fanos.patch"
+    "${patchSrc}/0012-disable-doc-cmark.patch"
+    "${patchSrc}/0013-fix-pyverify.patch"
+    "${patchSrc}/0015-fix-compiled-extension-import-paths.patch"
+  ];
+
+  configureFlags = [
+    "--without-readline"
+  ];
+
+  nativeBuildInputs = [
+    re2c
+    file
+    makeWrapper
+  ];
+
+  propagatedBuildInputs = [
+    six
+    typing
+  ];
+
+  doCheck = true;
+
+  preBuild = ''
+    build/py.sh all
+  '';
+
+  postPatch = ''
+    patchShebangs asdl build core doctools frontend pyext oil_lang ysh
+    rm cpp/stdlib.h # keep modules from finding the wrong stdlib?
+    # work around hard parse failure documented in oilshell/oil#1468
+    substituteInPlace osh/cmd_parse.py --replace 'elif self.c_id == Id.Op_LParen' 'elif False'
+  '';
+
+  # See earlier note on glibcLocales TODO: verify needed?
+  LOCALE_ARCHIVE = lib.optionalString (
+    stdenv.buildPlatform.libc == "glibc"
+  ) "${glibcLocales}/lib/locale/locale-archive";
+
+  # not exhaustive; sample what resholve uses as a sanity check
+  pythonImportsCheck = [
+    "oil"
+    "oil.asdl"
+    "oil.core"
+    "oil.frontend"
+    "oil._devbuild"
+    "oil._devbuild.gen.id_kind_asdl"
+    "oil._devbuild.gen.syntax_asdl"
+    "oil.osh"
+    "oil.tools.ysh_ify"
+  ];
+
+  meta = {
+    license = with lib.licenses; [
+      psfl # Includes a portion of the python interpreter and standard library
+      asl20 # Licence for Oil itself
+    ];
+  };
+}
diff --git a/pkgs/development/python2-modules/pip/default.nix b/pkgs/development/misc/resholve/python2-modules/pip/default.nix
similarity index 100%
rename from pkgs/development/python2-modules/pip/default.nix
rename to pkgs/development/misc/resholve/python2-modules/pip/default.nix
diff --git a/pkgs/development/misc/resholve/python2-modules/sedparse/default.nix b/pkgs/development/misc/resholve/python2-modules/sedparse/default.nix
new file mode 100644
index 000000000000..3426d25d23a0
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-modules/sedparse/default.nix
@@ -0,0 +1,24 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+}:
+
+buildPythonPackage {
+  pname = "sedparse";
+  version = "0.1.2";
+  format = "setuptools";
+
+  src = fetchFromGitHub {
+    owner = "aureliojargas";
+    repo = "sedparse";
+    rev = "0.1.2";
+    hash = "sha256-Q17A/oJ3GZbdSK55hPaMdw85g43WhTW9tuAuJtDfHHU=";
+  };
+
+  meta = {
+    description = "Python port of GNU sed's parser";
+    homepage = "https://github.com/aureliojargas/sedparse";
+    license = lib.licenses.gpl3Plus;
+  };
+}
diff --git a/pkgs/development/python2-modules/setuptools/default.nix b/pkgs/development/misc/resholve/python2-modules/setuptools/default.nix
similarity index 100%
rename from pkgs/development/python2-modules/setuptools/default.nix
rename to pkgs/development/misc/resholve/python2-modules/setuptools/default.nix
diff --git a/pkgs/development/python2-modules/setuptools/tag-date.patch b/pkgs/development/misc/resholve/python2-modules/setuptools/tag-date.patch
similarity index 100%
rename from pkgs/development/python2-modules/setuptools/tag-date.patch
rename to pkgs/development/misc/resholve/python2-modules/setuptools/tag-date.patch
diff --git a/pkgs/development/misc/resholve/python2-modules/six/default.nix b/pkgs/development/misc/resholve/python2-modules/six/default.nix
new file mode 100644
index 000000000000..951c42c107d1
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-modules/six/default.nix
@@ -0,0 +1,24 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchPypi,
+}:
+
+buildPythonPackage rec {
+  pname = "six";
+  version = "1.16.0";
+  format = "setuptools";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1e61c37477a1626458e36f7b1d82aa5c9b094fa4802892072e49de9c60c4c926";
+  };
+
+  doCheck = false;
+
+  meta = {
+    description = "Python 2 and 3 compatibility library";
+    homepage = "https://pypi.org/project/six/";
+    license = lib.licenses.mit;
+  };
+}
diff --git a/pkgs/development/misc/resholve/python2-modules/typing/default.nix b/pkgs/development/misc/resholve/python2-modules/typing/default.nix
new file mode 100644
index 000000000000..d26e5e2da706
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-modules/typing/default.nix
@@ -0,0 +1,24 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchPypi,
+}:
+
+buildPythonPackage rec {
+  pname = "typing";
+  version = "3.10.0.0";
+  format = "setuptools";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "13b4ad211f54ddbf93e5901a9967b1e07720c1d1b78d596ac6a439641aa1b130";
+  };
+
+  doCheck = false;
+
+  meta = {
+    description = "Backport of typing module to Python versions older than 3.5";
+    homepage = "https://docs.python.org/3/library/typing.html";
+    license = lib.licenses.psfl;
+  };
+}
diff --git a/pkgs/development/python2-modules/wheel/0001-tests-Rename-a-a-o-_-.py-_-.py.patch b/pkgs/development/misc/resholve/python2-modules/wheel/0001-tests-Rename-a-a-o-_-.py-_-.py.patch
similarity index 100%
rename from pkgs/development/python2-modules/wheel/0001-tests-Rename-a-a-o-_-.py-_-.py.patch
rename to pkgs/development/misc/resholve/python2-modules/wheel/0001-tests-Rename-a-a-o-_-.py-_-.py.patch
diff --git a/pkgs/development/python2-modules/wheel/default.nix b/pkgs/development/misc/resholve/python2-modules/wheel/default.nix
similarity index 100%
rename from pkgs/development/python2-modules/wheel/default.nix
rename to pkgs/development/misc/resholve/python2-modules/wheel/default.nix
diff --git a/pkgs/development/misc/resholve/python2-packages.nix b/pkgs/development/misc/resholve/python2-packages.nix
new file mode 100644
index 000000000000..45e066d3311c
--- /dev/null
+++ b/pkgs/development/misc/resholve/python2-packages.nix
@@ -0,0 +1,29 @@
+# Python 2 overlay applied to resholve's local python27 package set.
+# Provides the bootstrap toolchain (bootstrapped-pip/pip/setuptools/wheel)
+# plus resholve's own python2 build dependencies, kept here so all of
+# resholve's python2 surface lives in one place.
+
+self: super:
+
+with self;
+with super;
+{
+  bootstrapped-pip = toPythonModule (callPackage ./python2-modules/bootstrapped-pip { });
+
+  pip = callPackage ./python2-modules/pip { };
+
+  setuptools = callPackage ./python2-modules/setuptools { };
+
+  wheel = callPackage ./python2-modules/wheel { };
+
+  # resholve build deps
+  configargparse = callPackage ./python2-modules/configargparse { };
+
+  six = callPackage ./python2-modules/six { };
+
+  typing = callPackage ./python2-modules/typing { };
+
+  oildev = callPackage ./python2-modules/oildev { };
+
+  sedparse = callPackage ./python2-modules/sedparse { };
+}
diff --git a/pkgs/development/interpreters/python/python2/mk-python-derivation.nix b/pkgs/development/misc/resholve/python2/mk-python-derivation.nix
similarity index 100%
rename from pkgs/development/interpreters/python/python2/mk-python-derivation.nix
rename to pkgs/development/misc/resholve/python2/mk-python-derivation.nix
diff --git a/pkgs/development/misc/resholve/python27.nix b/pkgs/development/misc/resholve/python27.nix
new file mode 100644
index 000000000000..677cf13dc0d8
--- /dev/null
+++ b/pkgs/development/misc/resholve/python27.nix
@@ -0,0 +1,69 @@
+{
+  lib,
+  pkgsBuildHost,
+}:
+
+let
+  removeKnownVulnerabilities =
+    pkg:
+    pkg.overrideAttrs (old: {
+      meta = (old.meta or { }) // {
+        knownVulnerabilities = [ ];
+      };
+    });
+
+  passthruFun = import ../../interpreters/python/passthrufun.nix {
+    inherit lib;
+    inherit (pkgsBuildHost)
+      stdenv
+      callPackage
+      pythonPackagesExtensions
+      config
+      makeScopeWithSplicing'
+      ;
+  };
+
+  python27Base = pkgsBuildHost.callPackage ./cpython-2.7 {
+    self = python27;
+    sourceVersion = {
+      major = "2";
+      minor = "7";
+      patch = "18";
+      suffix = ".12"; # ActiveState's Python 2 extended support
+    };
+    hash = "sha256-RuEgfpags9wJm9Xe0daotqUx4knABEUc7DvtgnQXEfE=";
+    inherit passthruFun;
+  };
+
+  # We are removing `meta.knownVulnerabilities` from `python27`,
+  # and setting it in `resholve` itself.
+  python27 = (removeKnownVulnerabilities python27Base).override {
+    self = python27;
+    pkgsBuildHost = pkgsBuildHost // {
+      inherit python27;
+    };
+    # python2-only overrides for bootstrapped-pip/pip/setuptools/wheel
+    # (no longer applied globally — kept local to resholve)
+    packageOverrides = lib.composeExtensions (import ./python2-packages.nix) (
+      _self: super: {
+        pip = removeKnownVulnerabilities super.pip;
+        setuptools = removeKnownVulnerabilities super.setuptools;
+      }
+    );
+    # strip down that python version as much as possible
+    openssl = null;
+    bzip2 = null;
+    readline = null;
+    ncurses = null;
+    gdbm = null;
+    sqlite = null;
+    rebuildBytecode = false;
+    stripBytecode = true;
+    strip2to3 = true;
+    stripConfig = true;
+    stripIdlelib = true;
+    stripTests = true;
+    enableOptimizations = false;
+  };
+in
+python27
diff --git a/pkgs/development/misc/resholve/resholve.nix b/pkgs/development/misc/resholve/resholve.nix
index 16c9924510e3..67200729d4ef 100644
--- a/pkgs/development/misc/resholve/resholve.nix
+++ b/pkgs/development/misc/resholve/resholve.nix
@@ -1,32 +1,16 @@
 {
   lib,
   callPackage,
-  python27,
-  fetchFromGitHub,
   installShellFiles,
   rSrc,
   version,
-  oildev,
-  configargparse,
   gawk,
   binlore,
   resholve,
   resholve-utils,
 }:
-
 let
-  sedparse = python27.pkgs.buildPythonPackage {
-    pname = "sedparse";
-    version = "0.1.2";
-    format = "setuptools";
-    src = fetchFromGitHub {
-      owner = "aureliojargas";
-      repo = "sedparse";
-      rev = "0.1.2";
-      hash = "sha256-Q17A/oJ3GZbdSK55hPaMdw85g43WhTW9tuAuJtDfHHU=";
-    };
-  };
-
+  python27 = callPackage ./python27.nix { };
 in
 python27.pkgs.buildPythonApplication {
   pname = "resholve";
@@ -35,7 +19,7 @@ python27.pkgs.buildPythonApplication {
 
   nativeBuildInputs = [ installShellFiles ];
 
-  propagatedBuildInputs = [
+  propagatedBuildInputs = with python27.pkgs; [
     oildev
     configargparse
     sedparse
diff --git a/pkgs/development/misc/resholve/test.nix b/pkgs/development/misc/resholve/test.nix
index 75b13b7c1900..a2cc8aaffe69 100644
--- a/pkgs/development/misc/resholve/test.nix
+++ b/pkgs/development/misc/resholve/test.nix
@@ -13,7 +13,6 @@
   bats,
   libressl,
   openssl,
-  python27,
   file,
   gettext,
   rSrc,
diff --git a/pkgs/development/python-modules/aiocontextvars/default.nix b/pkgs/development/python-modules/aiocontextvars/default.nix
index 7bcf18ee24d6..ee5c35e27fae 100644
--- a/pkgs/development/python-modules/aiocontextvars/default.nix
+++ b/pkgs/development/python-modules/aiocontextvars/default.nix
@@ -5,7 +5,6 @@
   setuptools,
   pytestCheckHook,
   pytest-asyncio,
-  isPy27,
 }:
 
 buildPythonPackage rec {
@@ -13,8 +12,6 @@ buildPythonPackage rec {
   version = "0.2.2";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "fantix";
     repo = "aiocontextvars";
diff --git a/pkgs/development/python-modules/aspell-python/default.nix b/pkgs/development/python-modules/aspell-python/default.nix
index 87784477ccbd..4bc47fe3bd51 100644
--- a/pkgs/development/python-modules/aspell-python/default.nix
+++ b/pkgs/development/python-modules/aspell-python/default.nix
@@ -4,7 +4,6 @@
   aspellDicts,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   pytestCheckHook,
   setuptools,
 }:
@@ -14,8 +13,6 @@ buildPythonPackage rec {
   version = "1.15";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     pname = "aspell-python-py3";
     inherit version;
diff --git a/pkgs/development/python-modules/awslambdaric/default.nix b/pkgs/development/python-modules/awslambdaric/default.nix
index 3a74d1e2c350..504834368922 100644
--- a/pkgs/development/python-modules/awslambdaric/default.nix
+++ b/pkgs/development/python-modules/awslambdaric/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytestCheckHook,
   autoconf,
   automake,
@@ -20,8 +19,6 @@ buildPythonPackage rec {
   version = "3.1.1";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "aws";
     repo = "aws-lambda-python-runtime-interface-client";
diff --git a/pkgs/development/python-modules/basiciw/default.nix b/pkgs/development/python-modules/basiciw/default.nix
index 45b1d5407db4..e21dcbfa9f61 100644
--- a/pkgs/development/python-modules/basiciw/default.nix
+++ b/pkgs/development/python-modules/basiciw/default.nix
@@ -4,7 +4,6 @@
   fetchPypi,
   gcc,
   wirelesstools,
-  isPy27,
   isPyPy,
 }:
 
@@ -13,7 +12,7 @@ buildPythonPackage rec {
   version = "0.2.2";
   format = "setuptools";
 
-  disabled = isPy27 || isPyPy;
+  disabled = isPyPy;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/beaker/default.nix b/pkgs/development/python-modules/beaker/default.nix
index aad6383f249e..bd556adcaef3 100644
--- a/pkgs/development/python-modules/beaker/default.nix
+++ b/pkgs/development/python-modules/beaker/default.nix
@@ -12,11 +12,8 @@
   sqlalchemy,
   pycrypto,
   cryptography,
-  isPy27,
   pytestCheckHook,
   setuptools,
-  funcsigs ? null,
-  pycryptopp ? null,
 }:
 
 buildPythonPackage rec {
@@ -38,10 +35,6 @@ buildPythonPackage rec {
     sqlalchemy
     pycrypto
     cryptography
-  ]
-  ++ lib.optionals isPy27 [
-    funcsigs
-    pycryptopp
   ];
 
   nativeCheckInputs = [
diff --git a/pkgs/development/python-modules/ci-info/default.nix b/pkgs/development/python-modules/ci-info/default.nix
index d3035a11df13..32b08f75003d 100644
--- a/pkgs/development/python-modules/ci-info/default.nix
+++ b/pkgs/development/python-modules/ci-info/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
   pytest,
   pytestCheckHook,
@@ -12,8 +11,6 @@ buildPythonPackage rec {
   format = "setuptools";
   pname = "ci-info";
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-H9UMvUAfKa3/7rGLBIniMtFqwadFisa8MW3qtq5TX7A=";
diff --git a/pkgs/development/python-modules/click-completion/default.nix b/pkgs/development/python-modules/click-completion/default.nix
index 5e06ace61034..c87468bd5955 100644
--- a/pkgs/development/python-modules/click-completion/default.nix
+++ b/pkgs/development/python-modules/click-completion/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
 
   # propagates
   click,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "click-completion";
   version = "0.5.2";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/coapthon3/default.nix b/pkgs/development/python-modules/coapthon3/default.nix
index 283633f6d04f..89795e6001ca 100644
--- a/pkgs/development/python-modules/coapthon3/default.nix
+++ b/pkgs/development/python-modules/coapthon3/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   cachetools,
   fetchFromGitHub,
-  isPy27,
   lib,
 }:
 
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "coapthon3";
   version = "1.0.2";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "Tanganelli";
diff --git a/pkgs/development/python-modules/debts/default.nix b/pkgs/development/python-modules/debts/default.nix
index ba8a49c20034..25d37cc566f1 100644
--- a/pkgs/development/python-modules/debts/default.nix
+++ b/pkgs/development/python-modules/debts/default.nix
@@ -3,7 +3,6 @@
   python,
   buildPythonPackage,
   fetchFromGitLab,
-  isPy27,
   jinja2,
   pytest,
 }:
@@ -22,8 +21,6 @@ buildPythonPackage rec {
     sha256 = "1d66nka81mv9c07mki78lp5hdajqv4cq6aq2k7bh3mhkc5hwnwlg";
   };
 
-  disabled = isPy27;
-
   propagatedBuildInputs = [ jinja2 ];
 
   nativeCheckInputs = [ pytest ];
diff --git a/pkgs/development/python-modules/digi-xbee/default.nix b/pkgs/development/python-modules/digi-xbee/default.nix
index 0d659cf4833c..e128ab588b06 100644
--- a/pkgs/development/python-modules/digi-xbee/default.nix
+++ b/pkgs/development/python-modules/digi-xbee/default.nix
@@ -1,7 +1,6 @@
 {
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   pyserial,
   srp,
   lib,
@@ -11,7 +10,6 @@ buildPythonPackage rec {
   pname = "digi-xbee";
   version = "1.5.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     pname = "digi_xbee";
diff --git a/pkgs/development/python-modules/etesync/default.nix b/pkgs/development/python-modules/etesync/default.nix
index e1310b1ef37d..c5ce2cd1685e 100644
--- a/pkgs/development/python-modules/etesync/default.nix
+++ b/pkgs/development/python-modules/etesync/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   appdirs,
   asn1crypto,
   cffi,
@@ -29,7 +28,6 @@ buildPythonPackage rec {
   pname = "etesync";
   version = "0.12.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/exdown/default.nix b/pkgs/development/python-modules/exdown/default.nix
index 0b1b0bf32747..7ee213a87409 100644
--- a/pkgs/development/python-modules/exdown/default.nix
+++ b/pkgs/development/python-modules/exdown/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
   setuptools,
   pytestCheckHook,
@@ -12,8 +11,6 @@ buildPythonPackage rec {
   version = "0.9.0";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     extension = "zip";
diff --git a/pkgs/development/python-modules/executor/default.nix b/pkgs/development/python-modules/executor/default.nix
index 6a93631fe79b..685b9ffa6b81 100644
--- a/pkgs/development/python-modules/executor/default.nix
+++ b/pkgs/development/python-modules/executor/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   fetchFromGitHub,
   setuptools,
-  isPy27,
   pythonAtLeast,
   coloredlogs,
   humanfriendly,
@@ -21,7 +20,7 @@ buildPythonPackage rec {
   format = "setuptools";
 
   # pipes is removed in python 3.13
-  disabled = isPy27 || pythonAtLeast "3.13";
+  disabled = pythonAtLeast "3.13";
 
   src = fetchFromGitHub {
     owner = "xolox";
diff --git a/pkgs/development/python-modules/gibberish-detector/default.nix b/pkgs/development/python-modules/gibberish-detector/default.nix
index e30677548552..9b432d32c042 100644
--- a/pkgs/development/python-modules/gibberish-detector/default.nix
+++ b/pkgs/development/python-modules/gibberish-detector/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytestCheckHook,
 }:
 
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "gibberish-detector";
   version = "0.1.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "domanchi";
diff --git a/pkgs/development/python-modules/gumath/default.nix b/pkgs/development/python-modules/gumath/default.nix
index f478acffb27e..765793f90ea4 100644
--- a/pkgs/development/python-modules/gumath/default.nix
+++ b/pkgs/development/python-modules/gumath/default.nix
@@ -10,13 +10,11 @@
   libndtypes,
   libxnd,
   libgumath,
-  isPy27,
 }:
 
 buildPythonPackage {
   pname = "gumath";
   format = "setuptools";
-  disabled = isPy27;
   inherit (libgumath) src version meta;
 
   patches = [
diff --git a/pkgs/development/python-modules/halo/default.nix b/pkgs/development/python-modules/halo/default.nix
index 094331f54f75..9750b7686691 100644
--- a/pkgs/development/python-modules/halo/default.nix
+++ b/pkgs/development/python-modules/halo/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   colorama,
   fetchPypi,
-  isPy27,
   lib,
   log-symbols,
   six,
@@ -14,7 +13,6 @@ buildPythonPackage (finalAttrs: {
   pname = "halo";
   version = "0.0.31";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit (finalAttrs) pname version;
diff --git a/pkgs/development/python-modules/hyperlink/default.nix b/pkgs/development/python-modules/hyperlink/default.nix
index 05f774c3dc43..3bfd9a6e2ca6 100644
--- a/pkgs/development/python-modules/hyperlink/default.nix
+++ b/pkgs/development/python-modules/hyperlink/default.nix
@@ -2,9 +2,7 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   idna,
-  typing ? null,
 }:
 
 buildPythonPackage rec {
@@ -17,7 +15,7 @@ buildPythonPackage rec {
     sha256 = "0sx50lkivsfjxx9zr4yh7l9gll2l9kvl0v0w8w4wk2x5v9bzjyj2";
   };
 
-  propagatedBuildInputs = [ idna ] ++ lib.optionals isPy27 [ typing ];
+  propagatedBuildInputs = [ idna ];
 
   meta = {
     description = "Featureful, correct URL for Python";
diff --git a/pkgs/development/python-modules/inflection/default.nix b/pkgs/development/python-modules/inflection/default.nix
index ed8cc71addac..a4b0b46ffb4a 100644
--- a/pkgs/development/python-modules/inflection/default.nix
+++ b/pkgs/development/python-modules/inflection/default.nix
@@ -2,7 +2,6 @@
   lib,
   fetchPypi,
   buildPythonPackage,
-  isPy27,
   pytest,
 }:
 
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "inflection";
   version = "0.5.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/ipydatawidgets/default.nix b/pkgs/development/python-modules/ipydatawidgets/default.nix
index 80539b22e3e0..68a1e2967d8a 100644
--- a/pkgs/development/python-modules/ipydatawidgets/default.nix
+++ b/pkgs/development/python-modules/ipydatawidgets/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   pytestCheckHook,
   nbval,
   jupyter-packaging,
@@ -19,8 +18,6 @@ buildPythonPackage rec {
   version = "4.3.5";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-OU8kiVdlh8/XVTd6CaBn9GytIggZZQkgIf0avL54Uqg=";
diff --git a/pkgs/development/python-modules/jaraco-classes/default.nix b/pkgs/development/python-modules/jaraco-classes/default.nix
index 01f4514eafb5..1e1eb826b7d7 100644
--- a/pkgs/development/python-modules/jaraco-classes/default.nix
+++ b/pkgs/development/python-modules/jaraco-classes/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   setuptools-scm,
   more-itertools,
   pytestCheckHook,
@@ -13,8 +12,6 @@ buildPythonPackage rec {
   version = "3.4.0";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "jaraco";
     repo = "jaraco.classes";
diff --git a/pkgs/development/python-modules/javaobj-py3/default.nix b/pkgs/development/python-modules/javaobj-py3/default.nix
index 72696d60e7a2..52d42233e8b1 100644
--- a/pkgs/development/python-modules/javaobj-py3/default.nix
+++ b/pkgs/development/python-modules/javaobj-py3/default.nix
@@ -1,7 +1,6 @@
 {
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   lib,
   numpy,
 }:
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "javaobj-py3";
   version = "0.4.4";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/json-rpc/default.nix b/pkgs/development/python-modules/json-rpc/default.nix
index 10e4ae35245f..477c48b91abb 100644
--- a/pkgs/development/python-modules/json-rpc/default.nix
+++ b/pkgs/development/python-modules/json-rpc/default.nix
@@ -1,15 +1,10 @@
 {
   lib,
-  isPy27,
   buildPythonPackage,
   fetchPypi,
   pytestCheckHook,
-  mock,
 }:
 
-let
-  pythonEnv = lib.optional isPy27 mock;
-in
 buildPythonPackage rec {
   pname = "json-rpc";
   version = "1.15.0";
@@ -20,9 +15,7 @@ buildPythonPackage rec {
     hash = "sha256-5kQdVsHc1UJByTfQotzRk73wvcU5tTFlJHE/VUt/hbk=";
   };
 
-  nativeCheckInputs = pythonEnv ++ [ pytestCheckHook ];
-
-  nativeBuildInputs = pythonEnv;
+  nativeCheckInputs = [ pytestCheckHook ];
 
   meta = {
     description = "JSON-RPC 1/2 transport implementation";
diff --git a/pkgs/development/python-modules/manuel/default.nix b/pkgs/development/python-modules/manuel/default.nix
index 6fcb892bd977..fd66f5dab78c 100644
--- a/pkgs/development/python-modules/manuel/default.nix
+++ b/pkgs/development/python-modules/manuel/default.nix
@@ -4,7 +4,6 @@
   fetchPypi,
   fetchpatch,
   python,
-  isPy27,
   six,
   zope-testing,
 }:
@@ -13,7 +12,6 @@ buildPythonPackage rec {
   pname = "manuel";
   version = "1.13.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/matchpy/default.nix b/pkgs/development/python-modules/matchpy/default.nix
index b66bfccc410e..83a82ef0251a 100644
--- a/pkgs/development/python-modules/matchpy/default.nix
+++ b/pkgs/development/python-modules/matchpy/default.nix
@@ -8,14 +8,12 @@
   pytestCheckHook,
   hypothesis,
   setuptools-scm,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "matchpy";
   version = "0.5.5"; # Don't upgrade to 4.3.1, this tag is very old
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "HPAC";
diff --git a/pkgs/development/python-modules/mergedeep/default.nix b/pkgs/development/python-modules/mergedeep/default.nix
index eeb055381880..6854d80dc3c9 100644
--- a/pkgs/development/python-modules/mergedeep/default.nix
+++ b/pkgs/development/python-modules/mergedeep/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchFromGitHub,
   pytest,
 }:
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "mergedeep";
   version = "1.3.4";
   format = "setuptools";
-  disabled = isPy27;
 
   # PyPI tarball doesn't include tests directory
   src = fetchFromGitHub {
diff --git a/pkgs/development/python-modules/mlrose/default.nix b/pkgs/development/python-modules/mlrose/default.nix
index 0ec60de6f4d8..21431e8a373e 100644
--- a/pkgs/development/python-modules/mlrose/default.nix
+++ b/pkgs/development/python-modules/mlrose/default.nix
@@ -1,6 +1,5 @@
 {
   lib,
-  isPy27,
   buildPythonPackage,
   fetchFromGitHub,
   fetchpatch,
@@ -14,7 +13,6 @@ buildPythonPackage rec {
   pname = "mlrose";
   version = "1.3.0";
   pyproject = true;
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "gkhayes";
diff --git a/pkgs/development/python-modules/mlxtend/default.nix b/pkgs/development/python-modules/mlxtend/default.nix
index 8b0cf517676d..886238be38e4 100644
--- a/pkgs/development/python-modules/mlxtend/default.nix
+++ b/pkgs/development/python-modules/mlxtend/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   setuptools,
   pytestCheckHook,
   scipy,
@@ -18,8 +17,6 @@ buildPythonPackage rec {
   version = "0.24.0";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "rasbt";
     repo = "mlxtend";
diff --git a/pkgs/development/python-modules/mnist/default.nix b/pkgs/development/python-modules/mnist/default.nix
index 23cb82eaf307..ff90bccc086c 100644
--- a/pkgs/development/python-modules/mnist/default.nix
+++ b/pkgs/development/python-modules/mnist/default.nix
@@ -1,9 +1,7 @@
 {
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   lib,
-  mock,
   numpy,
   pytestCheckHook,
 }:
@@ -20,7 +18,7 @@ buildPythonPackage rec {
     sha256 = "17r37pbxiv5dw857bmg990x836gq6sgww069w3q5jjg9m3xdm7dh";
   };
 
-  propagatedBuildInputs = [ numpy ] ++ lib.optional isPy27 mock;
+  propagatedBuildInputs = [ numpy ];
 
   nativeCheckInputs = [ pytestCheckHook ];
 
diff --git a/pkgs/development/python-modules/mongoengine/default.nix b/pkgs/development/python-modules/mongoengine/default.nix
index 0c7e59f6a6fa..a4392d767292 100644
--- a/pkgs/development/python-modules/mongoengine/default.nix
+++ b/pkgs/development/python-modules/mongoengine/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   fetchFromGitHub,
   pymongo,
-  isPy27,
   six,
   blinker,
   pytestCheckHook,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "mongoengine";
   version = "0.29.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "MongoEngine";
diff --git a/pkgs/development/python-modules/mongoquery/default.nix b/pkgs/development/python-modules/mongoquery/default.nix
index 01a1985031df..ae4a0cfc88d5 100644
--- a/pkgs/development/python-modules/mongoquery/default.nix
+++ b/pkgs/development/python-modules/mongoquery/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   fetchPypi,
   six,
-  isPy27,
 }:
 
 buildPythonPackage rec {
@@ -11,8 +10,6 @@ buildPythonPackage rec {
   version = "1.4.3";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     sha256 = "sha256-6QH4buWvfvbtovLCb0vSz+g4DYHxeLfjYH27zc7pcjk=";
diff --git a/pkgs/development/python-modules/ms-cv/default.nix b/pkgs/development/python-modules/ms-cv/default.nix
index 840a1a7a2285..a77a245a2f01 100644
--- a/pkgs/development/python-modules/ms-cv/default.nix
+++ b/pkgs/development/python-modules/ms-cv/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchFromGitHub,
   pytestCheckHook,
 }:
@@ -11,8 +10,6 @@ buildPythonPackage rec {
   version = "0.1.1";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "OpenXbox";
     repo = "ms_cv";
diff --git a/pkgs/development/python-modules/ndtypes/default.nix b/pkgs/development/python-modules/ndtypes/default.nix
index 21b13ffee682..95419e06d9b6 100644
--- a/pkgs/development/python-modules/ndtypes/default.nix
+++ b/pkgs/development/python-modules/ndtypes/default.nix
@@ -5,13 +5,11 @@
   python,
   numpy,
   libndtypes,
-  isPy27,
 }:
 
 buildPythonPackage {
   pname = "ndtypes";
   format = "setuptools";
-  disabled = isPy27;
   inherit (libndtypes) version src meta;
 
   outputs = [
diff --git a/pkgs/development/python-modules/nixpkgs-pytools/default.nix b/pkgs/development/python-modules/nixpkgs-pytools/default.nix
index 103286a0f0b1..0b6c2aad4d88 100644
--- a/pkgs/development/python-modules/nixpkgs-pytools/default.nix
+++ b/pkgs/development/python-modules/nixpkgs-pytools/default.nix
@@ -5,14 +5,12 @@
   jinja2,
   setuptools,
   rope,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "nixpkgs-pytools";
   version = "1.3.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/nplusone/default.nix b/pkgs/development/python-modules/nplusone/default.nix
index 5f4bdc99f89d..5cbb845e9e74 100644
--- a/pkgs/development/python-modules/nplusone/default.nix
+++ b/pkgs/development/python-modules/nplusone/default.nix
@@ -6,7 +6,6 @@
   fetchFromGitHub,
   flake8,
   flask-sqlalchemy,
-  isPy27,
   mock,
   peewee,
   pytest-django,
@@ -21,7 +20,6 @@ buildPythonPackage rec {
   pname = "nplusone";
   version = "1.0.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "jmcarp";
diff --git a/pkgs/development/python-modules/opuslib/default.nix b/pkgs/development/python-modules/opuslib/default.nix
index b7a02b04a9d8..f2f0d8c973bc 100644
--- a/pkgs/development/python-modules/opuslib/default.nix
+++ b/pkgs/development/python-modules/opuslib/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   fetchFromGitHub,
   fetchpatch,
-  isPy27,
   libopus,
   pytestCheckHook,
   lib,
@@ -16,8 +15,6 @@ buildPythonPackage {
   version = "3.0.3";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "orion-labs";
     repo = "opuslib";
diff --git a/pkgs/development/python-modules/piccata/default.nix b/pkgs/development/python-modules/piccata/default.nix
index 720433461cf1..cefec10cb7f4 100644
--- a/pkgs/development/python-modules/piccata/default.nix
+++ b/pkgs/development/python-modules/piccata/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytestCheckHook,
 }:
 
@@ -11,8 +10,6 @@ buildPythonPackage rec {
   version = "2.0.3";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "NordicSemiconductor";
     repo = "piccata";
diff --git a/pkgs/development/python-modules/plexauth/default.nix b/pkgs/development/python-modules/plexauth/default.nix
index aba650e2cbef..9831ba3b8140 100644
--- a/pkgs/development/python-modules/plexauth/default.nix
+++ b/pkgs/development/python-modules/plexauth/default.nix
@@ -3,14 +3,12 @@
   buildPythonPackage,
   fetchFromGitHub,
   aiohttp,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "plexauth";
   version = "0.0.6";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "jjlawren";
diff --git a/pkgs/development/python-modules/pooch/default.nix b/pkgs/development/python-modules/pooch/default.nix
index 3275848c97da..ebd4220c69a3 100644
--- a/pkgs/development/python-modules/pooch/default.nix
+++ b/pkgs/development/python-modules/pooch/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
   setuptools,
   setuptools-scm,
@@ -20,8 +19,6 @@ buildPythonPackage rec {
   version = "1.8.2";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-dlYfDeaKAdpN9q846ZVcTJ0aXJDac/fkAnalco7IPRA=";
diff --git a/pkgs/development/python-modules/pq/default.nix b/pkgs/development/python-modules/pq/default.nix
index 63f4fc43c848..e6a3ee02086d 100644
--- a/pkgs/development/python-modules/pq/default.nix
+++ b/pkgs/development/python-modules/pq/default.nix
@@ -2,14 +2,12 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "pq";
   version = "1.9.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/py-air-control-exporter/default.nix b/pkgs/development/python-modules/py-air-control-exporter/default.nix
index 45e69dd12445..2b3290c32b94 100644
--- a/pkgs/development/python-modules/py-air-control-exporter/default.nix
+++ b/pkgs/development/python-modules/py-air-control-exporter/default.nix
@@ -4,7 +4,6 @@
   click,
   fetchPypi,
   flask,
-  isPy27,
   nixosTests,
   prometheus-client,
   py-air-control,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "py-air-control-exporter";
   version = "0.3.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/py-sonic/default.nix b/pkgs/development/python-modules/py-sonic/default.nix
index 322454a2f59d..d1689fcc7c08 100644
--- a/pkgs/development/python-modules/py-sonic/default.nix
+++ b/pkgs/development/python-modules/py-sonic/default.nix
@@ -2,14 +2,12 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "py-sonic";
   version = "1.0.3";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/pyaehw4a1/default.nix b/pkgs/development/python-modules/pyaehw4a1/default.nix
index ab7dc9d4b854..b10e845296c4 100644
--- a/pkgs/development/python-modules/pyaehw4a1/default.nix
+++ b/pkgs/development/python-modules/pyaehw4a1/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchFromGitHub,
 }:
 
@@ -10,8 +9,6 @@ buildPythonPackage rec {
   version = "0.3.9";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "bannhead";
     repo = "pyaehw4a1";
diff --git a/pkgs/development/python-modules/pycmarkgfm/default.nix b/pkgs/development/python-modules/pycmarkgfm/default.nix
index 80a3fefcb45c..e3ef26bd7c20 100644
--- a/pkgs/development/python-modules/pycmarkgfm/default.nix
+++ b/pkgs/development/python-modules/pycmarkgfm/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   cffi,
   pytest,
 }:
@@ -11,7 +10,6 @@ buildPythonPackage rec {
   pname = "pycmarkgfm";
   version = "1.2.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/pyenchant/default.nix b/pkgs/development/python-modules/pyenchant/default.nix
index 3ca3b126b8f3..4c0ac8884e18 100644
--- a/pkgs/development/python-modules/pyenchant/default.nix
+++ b/pkgs/development/python-modules/pyenchant/default.nix
@@ -2,7 +2,6 @@
   lib,
   stdenv,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
   enchant_2,
 }:
@@ -11,7 +10,6 @@ buildPythonPackage rec {
   pname = "pyenchant";
   version = "3.3.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/pypubsub/default.nix b/pkgs/development/python-modules/pypubsub/default.nix
index 3b4f97f73a61..b37b97e135fa 100644
--- a/pkgs/development/python-modules/pypubsub/default.nix
+++ b/pkgs/development/python-modules/pypubsub/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytest,
 }:
 
@@ -10,7 +9,6 @@ buildPythonPackage {
   pname = "pypubsub";
   version = "4.0.3";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "schollii";
diff --git a/pkgs/development/python-modules/pyqt/5.x.nix b/pkgs/development/python-modules/pyqt/5.x.nix
index 85cedbede6af..89f5cc650dca 100644
--- a/pkgs/development/python-modules/pyqt/5.x.nix
+++ b/pkgs/development/python-modules/pyqt/5.x.nix
@@ -3,7 +3,6 @@
   stdenv,
   buildPythonPackage,
   setuptools,
-  isPy27,
   fetchPypi,
   pkg-config,
   dbus,
@@ -30,8 +29,6 @@ buildPythonPackage rec {
   version = "5.15.10";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     pname = "PyQt5";
     inherit version;
diff --git a/pkgs/development/python-modules/pytest-helpers-namespace/default.nix b/pkgs/development/python-modules/pytest-helpers-namespace/default.nix
index 5de6872ce99e..f9b58f18bad5 100644
--- a/pkgs/development/python-modules/pytest-helpers-namespace/default.nix
+++ b/pkgs/development/python-modules/pytest-helpers-namespace/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   fetchPypi,
   pytestCheckHook,
-  isPy27,
   lib,
   setuptools,
   setuptools-declarative-requirements,
@@ -13,7 +12,6 @@ buildPythonPackage rec {
   pname = "pytest-helpers-namespace";
   version = "2021.12.29";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/pytest-tornasync/default.nix b/pkgs/development/python-modules/pytest-tornasync/default.nix
index f66343a8823b..12d82c4ee36c 100644
--- a/pkgs/development/python-modules/pytest-tornasync/default.nix
+++ b/pkgs/development/python-modules/pytest-tornasync/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytest,
   tornado,
 }:
@@ -11,7 +10,6 @@ buildPythonPackage {
   pname = "pytest-tornasync";
   version = "0.6.0.post2";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "eukaryote";
diff --git a/pkgs/development/python-modules/pyxl3/default.nix b/pkgs/development/python-modules/pyxl3/default.nix
index 47f40cab27e0..f656f3dfa416 100644
--- a/pkgs/development/python-modules/pyxl3/default.nix
+++ b/pkgs/development/python-modules/pyxl3/default.nix
@@ -3,14 +3,12 @@
   buildPythonPackage,
   fetchFromGitHub,
   pytestCheckHook,
-  isPy27,
 }:
 
 buildPythonPackage {
   pname = "pyxl3";
   version = "1.4";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "gvanrossum";
diff --git a/pkgs/development/python-modules/reparser/default.nix b/pkgs/development/python-modules/reparser/default.nix
index 5d35bc128083..b1749ded00e6 100644
--- a/pkgs/development/python-modules/reparser/default.nix
+++ b/pkgs/development/python-modules/reparser/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchFromGitHub,
 }:
 
@@ -10,8 +9,6 @@ buildPythonPackage rec {
   version = "1.4.3";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "xmikos";
     repo = "reparser";
diff --git a/pkgs/development/python-modules/roku/default.nix b/pkgs/development/python-modules/roku/default.nix
index 5baae3a107e8..cd560fd2cca9 100644
--- a/pkgs/development/python-modules/roku/default.nix
+++ b/pkgs/development/python-modules/roku/default.nix
@@ -5,14 +5,12 @@
   requests,
   pytest,
   flask,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   version = "4.1";
   format = "setuptools";
   pname = "roku";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "jcarbaugh";
diff --git a/pkgs/development/python-modules/rtmixer/default.nix b/pkgs/development/python-modules/rtmixer/default.nix
index d2a83c7260ec..05a38a1ca7f3 100644
--- a/pkgs/development/python-modules/rtmixer/default.nix
+++ b/pkgs/development/python-modules/rtmixer/default.nix
@@ -1,7 +1,6 @@
 {
   fetchFromGitHub,
   buildPythonPackage,
-  isPy27,
   setuptools,
   cython,
   portaudio,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "rtmixer";
   version = "0.1.7";
   pyproject = true;
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "spatialaudio";
diff --git a/pkgs/development/python-modules/sansio-multipart/default.nix b/pkgs/development/python-modules/sansio-multipart/default.nix
index ef47ab77c7ed..aa12f71a01e7 100644
--- a/pkgs/development/python-modules/sansio-multipart/default.nix
+++ b/pkgs/development/python-modules/sansio-multipart/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
 }:
 
@@ -9,8 +8,6 @@ buildPythonPackage rec {
   pname = "sansio-multipart";
   version = "0.3";
 
-  disabled = isPy27;
-
   format = "setuptools";
 
   src = fetchPypi {
diff --git a/pkgs/development/python-modules/scikit-tda/default.nix b/pkgs/development/python-modules/scikit-tda/default.nix
index aa36b958343c..f6a2cc54fcbf 100644
--- a/pkgs/development/python-modules/scikit-tda/default.nix
+++ b/pkgs/development/python-modules/scikit-tda/default.nix
@@ -15,14 +15,12 @@
   kmapper,
   tadasets,
   pytest,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "scikit-tda";
   version = "1.1.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "scikit-tda";
diff --git a/pkgs/development/python-modules/segments/default.nix b/pkgs/development/python-modules/segments/default.nix
index 63968d773aee..60e3c961d0db 100644
--- a/pkgs/development/python-modules/segments/default.nix
+++ b/pkgs/development/python-modules/segments/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   setuptools,
   regex,
   csvw,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "segments";
   version = "2.4.0";
   pyproject = true;
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "cldf";
diff --git a/pkgs/development/python-modules/sgmllib3k/default.nix b/pkgs/development/python-modules/sgmllib3k/default.nix
index 3d488ca98eb0..d15858c59f03 100644
--- a/pkgs/development/python-modules/sgmllib3k/default.nix
+++ b/pkgs/development/python-modules/sgmllib3k/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   pytestCheckHook,
 }:
 
@@ -11,8 +10,6 @@ buildPythonPackage rec {
   version = "1.0.0";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-eGj7HIv6dkwaxWPTzzacOB0TJdNhJJM6cm8p/NqoEuk=";
diff --git a/pkgs/development/python-modules/simpleaudio/default.nix b/pkgs/development/python-modules/simpleaudio/default.nix
index 1518b29537ae..d0aa31dadddd 100644
--- a/pkgs/development/python-modules/simpleaudio/default.nix
+++ b/pkgs/development/python-modules/simpleaudio/default.nix
@@ -2,7 +2,6 @@
   alsa-lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   lib,
 }:
 
@@ -10,7 +9,6 @@ buildPythonPackage rec {
   pname = "simpleaudio";
   version = "1.0.4";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchFromGitHub {
     owner = "hamiltron";
diff --git a/pkgs/development/python-modules/simpy/default.nix b/pkgs/development/python-modules/simpy/default.nix
index c85eb0c4ad81..d042bbde7d4f 100644
--- a/pkgs/development/python-modules/simpy/default.nix
+++ b/pkgs/development/python-modules/simpy/default.nix
@@ -2,7 +2,6 @@
   lib,
   stdenv,
   buildPythonPackage,
-  isPy27,
   fetchPypi,
   setuptools,
   setuptools-scm,
@@ -16,8 +15,6 @@ buildPythonPackage rec {
   version = "4.1.1";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-BtB1CniEsR4OjiDOC8fG1O1fF0PUVmlTQNE/3/lQAaY=";
diff --git a/pkgs/development/python-modules/skein/default.nix b/pkgs/development/python-modules/skein/default.nix
index fa0168b0337c..c7d4995fc1cc 100644
--- a/pkgs/development/python-modules/skein/default.nix
+++ b/pkgs/development/python-modules/skein/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   callPackage,
   fetchPypi,
-  isPy27,
   pythonOlder,
   lib,
   cryptography,
@@ -11,7 +10,6 @@
   grpcio-tools,
   hadoop,
   pytestCheckHook,
-  python,
   setuptools,
   versioneer,
 }:
@@ -77,8 +75,5 @@ buildPythonPackage rec {
       alexbiehl
       illustris
     ];
-    problems = lib.optionalAttrs isPy27 {
-      broken.message = "${pname} not supported on ${python.executable}";
-    };
   };
 }
diff --git a/pkgs/development/python-modules/snapshot-restore-py/default.nix b/pkgs/development/python-modules/snapshot-restore-py/default.nix
index bb478bc8d11c..be8456cc2d58 100644
--- a/pkgs/development/python-modules/snapshot-restore-py/default.nix
+++ b/pkgs/development/python-modules/snapshot-restore-py/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytestCheckHook,
   setuptools,
 }:
@@ -11,8 +10,6 @@ buildPythonPackage rec {
   version = "1.0.0";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "aws";
     repo = "snapshot-restore-py";
diff --git a/pkgs/development/python-modules/sounddevice/default.nix b/pkgs/development/python-modules/sounddevice/default.nix
index 4a7e62dee817..3f3fdb55ad07 100644
--- a/pkgs/development/python-modules/sounddevice/default.nix
+++ b/pkgs/development/python-modules/sounddevice/default.nix
@@ -3,7 +3,6 @@
   stdenv,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   setuptools,
   cffi,
   numpy,
@@ -15,7 +14,6 @@ buildPythonPackage rec {
   pname = "sounddevice";
   version = "0.5.3";
   pyproject = true;
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/sphinxcontrib-jsmath/default.nix b/pkgs/development/python-modules/sphinxcontrib-jsmath/default.nix
index aba070269087..591091073f8b 100644
--- a/pkgs/development/python-modules/sphinxcontrib-jsmath/default.nix
+++ b/pkgs/development/python-modules/sphinxcontrib-jsmath/default.nix
@@ -2,14 +2,12 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
 }:
 
 buildPythonPackage (finalAttrs: {
   pname = "sphinxcontrib-jsmath";
   version = "1.0.1";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit (finalAttrs) pname version;
diff --git a/pkgs/development/python-modules/sphinxcontrib-openapi/default.nix b/pkgs/development/python-modules/sphinxcontrib-openapi/default.nix
index da92f50fbfb8..8a5a6b9fdbc9 100644
--- a/pkgs/development/python-modules/sphinxcontrib-openapi/default.nix
+++ b/pkgs/development/python-modules/sphinxcontrib-openapi/default.nix
@@ -3,7 +3,6 @@
   buildPythonPackage,
   deepmerge,
   fetchPypi,
-  isPy27,
   setuptools-scm,
   jsonschema,
   picobox,
@@ -16,7 +15,6 @@ buildPythonPackage rec {
   pname = "sphinxcontrib-openapi";
   version = "0.8.4";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/spiderpy/default.nix b/pkgs/development/python-modules/spiderpy/default.nix
index 5f247cca2cdc..d62ea82b6759 100644
--- a/pkgs/development/python-modules/spiderpy/default.nix
+++ b/pkgs/development/python-modules/spiderpy/default.nix
@@ -1,7 +1,6 @@
 {
   lib,
   buildPythonPackage,
-  isPy27,
   fetchFromGitHub,
   poetry-core,
   requests,
@@ -12,8 +11,6 @@ buildPythonPackage rec {
   version = "1.7.2";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "peternijssen";
     repo = "spiderpy";
diff --git a/pkgs/development/python-modules/spinners/default.nix b/pkgs/development/python-modules/spinners/default.nix
index 049894a49bb0..5b9df19c1368 100644
--- a/pkgs/development/python-modules/spinners/default.nix
+++ b/pkgs/development/python-modules/spinners/default.nix
@@ -1,7 +1,6 @@
 {
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   lib,
 }:
 
@@ -9,7 +8,6 @@ buildPythonPackage rec {
   pname = "spinners";
   version = "0.0.24";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     inherit pname version;
diff --git a/pkgs/development/python-modules/test-tube/default.nix b/pkgs/development/python-modules/test-tube/default.nix
index a7c90aa2c73e..977b78e0080d 100644
--- a/pkgs/development/python-modules/test-tube/default.nix
+++ b/pkgs/development/python-modules/test-tube/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
-  isPy27,
   pytestCheckHook,
   future,
   imageio,
@@ -17,8 +16,6 @@ buildPythonPackage rec {
   version = "0.628";
   format = "setuptools";
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "williamFalcon";
     repo = "test-tube";
diff --git a/pkgs/development/python-modules/tokenize-rt/default.nix b/pkgs/development/python-modules/tokenize-rt/default.nix
index 0133e47553c0..4dcf73be19fe 100644
--- a/pkgs/development/python-modules/tokenize-rt/default.nix
+++ b/pkgs/development/python-modules/tokenize-rt/default.nix
@@ -2,7 +2,6 @@
   buildPythonPackage,
   lib,
   fetchFromGitHub,
-  isPy27,
   setuptools,
   pytestCheckHook,
 }:
@@ -12,8 +11,6 @@ buildPythonPackage rec {
   version = "6.2.0";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchFromGitHub {
     owner = "asottile";
     repo = "tokenize-rt";
diff --git a/pkgs/development/python-modules/update-checker/default.nix b/pkgs/development/python-modules/update-checker/default.nix
index 54dc1c552357..f6100125a88a 100644
--- a/pkgs/development/python-modules/update-checker/default.nix
+++ b/pkgs/development/python-modules/update-checker/default.nix
@@ -3,14 +3,12 @@
   buildPythonPackage,
   fetchPypi,
   requests,
-  isPy27,
 }:
 
 buildPythonPackage rec {
   pname = "update-checker";
   version = "0.18.0";
   format = "setuptools";
-  disabled = isPy27;
 
   src = fetchPypi {
     pname = "update_checker";
diff --git a/pkgs/development/python-modules/venusian/default.nix b/pkgs/development/python-modules/venusian/default.nix
index 6b9a45b06fc0..5d60eff54efc 100644
--- a/pkgs/development/python-modules/venusian/default.nix
+++ b/pkgs/development/python-modules/venusian/default.nix
@@ -2,7 +2,6 @@
   lib,
   buildPythonPackage,
   fetchPypi,
-  isPy27,
   pytestCheckHook,
   pytest-cov-stub,
   setuptools,
@@ -13,8 +12,6 @@ buildPythonPackage rec {
   version = "3.1.1";
   pyproject = true;
 
-  disabled = isPy27;
-
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-U0+zs1VmkoPrOVRYGTHl0dBx/OYdAp1Y8yGaXjpvDEE=";
diff --git a/pkgs/development/python2-modules/README.md b/pkgs/development/python2-modules/README.md
deleted file mode 100644
index 97252d996691..000000000000
--- a/pkgs/development/python2-modules/README.md
+++ /dev/null
@@ -1,7 +0,0 @@
-# Python 2 is Not Supported
-
-Packages, applications, and services based on Python 2 are no longer supported and are being removed. If you require a Python 2-based package, you can include that package in your own local repository.
-
-Some packages may continue to be maintained for internal use by Nixpkgs, but they should not be used by new public packages.
-
-For more details, see [Issue #201859](https://github.com/NixOS/nixpkgs/pull/201859).
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index e1690f5858a1..33291f2d7943 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1816,15 +1816,21 @@ mapAliases {
   pyo3-pack = throw "'pyo3-pack' has been renamed to/replaced by 'maturin'"; # Converted to throw 2025-10-27
   pyotherside = warnAlias "'pyotherside' has been renamed to 'libsForQt5.pyotherside'. A Qt6 build is available at 'qt6Packages.pyotherside'."; # Added 2026-03-27
   pypolicyd-spf = throw "'pypolicyd-spf' has been renamed to/replaced by 'spf-engine'"; # Converted to throw 2025-10-27
+  python2 = throw "python2 has been removed; Python 2 is end-of-life. Use `python3` instead."; # Added 2026-05-03
+  python2Full = throw "python2Full has been removed; Python 2 is end-of-life. Use `python3` instead."; # Added 2026-05-03
+  python2Packages = throw "python2Packages has been removed; Python 2 is end-of-life. Use `python3Packages` instead."; # Added 2026-05-03
   python3Full = throw "python3Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
+  python27 = throw "python27 has been removed from the top-level package set; Python 2 is end-of-life. Use `python3` instead."; # Added 2026-05-03
+  python27Full = throw "python27Full has been removed; Python 2 is end-of-life. Use `python3` instead."; # Added 2026-05-03
+  python27Packages = throw "python27Packages has been removed; Python 2 is end-of-life. Use `python3Packages` instead."; # Added 2026-05-03
   python311Full = throw "python311Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python312Full = throw "python312Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python313Full = throw "python313Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python314Full = throw "python314Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
-  python = throw "`python` previously pointed to Python 2; use `python3` or `python2` if necessary"; # Converted to throw 2025-10-27
+  python = throw "`python` previously pointed to Python 2; use `python3` instead"; # Converted to throw 2025-10-27
   python-qt = throw "python-qt has been removed, because hard to maintain and not required by anything"; # Added 2025-01-14
-  pythonFull = throw "'pythonFull' previously pointed to Python 2; use `python3` or `python2Full` if necessary"; # Converted to throw 2025-10-27
-  pythonPackages = throw "`pythonPackages` previously pointed to Python 2; use `python3Packages` or `python2.pkgs` if necessary"; # Converted to throw 2025-10-27
+  pythonFull = throw "'pythonFull' previously pointed to Python 2; use `python3` instead"; # Converted to throw 2025-10-27
+  pythonPackages = throw "`pythonPackages` previously pointed to Python 2; use `python3Packages` instead"; # Converted to throw 2025-10-27
   pywal = pywal16; # Added 2026-02-01
   q2pro = throw "'q2pro' has been removed as upstream repository was deleted and no direct active forks were available."; # Added 2025-12-27
   qcachegrind = throw "'qcachegrind' has been removed, as it depends on KDE Gear 5, which has reached EOL"; # Added 2025-08-20
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 02a360aa1034..75ecd515cf1f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -4855,11 +4855,9 @@ with pkgs;
   # Python interpreters. All standard library modules are included except for tkinter, which is
   # available as `pythonPackages.tkinter` and can be used as any other Python package.
   # When switching these sets, please update docs at ../../doc/languages-frameworks/python.md
-  python2 = python27;
   python3 = python313;
 
   # pythonPackages further below, but assigned here because they need to be in sync
-  python2Packages = dontRecurseIntoAttrs python27Packages;
   python3Packages = dontRecurseIntoAttrs python313Packages;
 
   pypy = pypy2;
@@ -4868,16 +4866,6 @@ with pkgs;
 
   # Python interpreter that is build with all modules, including tkinter.
   # These are for compatibility and should not be used inside Nixpkgs.
-  python2Full = python2.override {
-    self = python2Full;
-    pythonAttr = "python2Full";
-    x11Support = true;
-  };
-  python27Full = python27.override {
-    self = python27Full;
-    pythonAttr = "python27Full";
-    x11Support = true;
-  };
 
   # https://py-free-threading.github.io
   python313FreeThreading = python313.override {
@@ -4898,7 +4886,6 @@ with pkgs;
 
   pythonInterpreters = callPackage ./../development/interpreters/python { };
   inherit (pythonInterpreters)
-    python27
     python311
     python312
     python313
@@ -4914,7 +4901,6 @@ with pkgs;
   pythonPackagesExtensions = [ ];
 
   # Python package sets.
-  python27Packages = python27.pkgs;
   python311Packages = python311.pkgs;
   python312Packages = python312.pkgs;
   python313Packages = recurseIntoAttrs python313.pkgs;
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f8b09738955a..2fe8b765a2a3 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8985,7 +8985,6 @@ self: super: with self; {
       p.overrideAttrs (super: {
         meta = super.meta // {
           outputsToInstall = [ "py" ];
-          broken = super.meta.broken or isPy27;
         };
       })
     )
diff --git a/pkgs/top-level/python2-packages.nix b/pkgs/top-level/python2-packages.nix
deleted file mode 100644
index 8784cb32b65a..000000000000
--- a/pkgs/top-level/python2-packages.nix
+++ /dev/null
@@ -1,71 +0,0 @@
-# Extension with Python 2 packages that is overlaid on top
-# of the Python 3 packages set. This way, Python 2+3 compatible
-# packages can still be used.
-
-self: super:
-
-with self;
-with super;
-{
-  attrs = disabled super.attrs;
-
-  bootstrapped-pip = toPythonModule (callPackage ../development/python2-modules/bootstrapped-pip { });
-
-  cffi = disabled super.cffi;
-
-  configparser = disabled super.configparser;
-
-  contextlib2 = disabled super.contextlib2;
-
-  coverage = disabled super.coverage;
-
-  filelock = disabled super.filelock;
-
-  hypothesis = disabled super.hypothesis;
-
-  importlib-metadata = disabled super.importlib-metadata;
-
-  jinja2 = disabled super.jinja2;
-
-  markupsafe = disabled super.markupsafe;
-
-  mock = disabled super.mock;
-
-  more-itertools = disabled super.more-itertools;
-
-  ninja = disabled super.ninja;
-
-  packaging = disabled super.packaging;
-
-  pip = callPackage ../development/python2-modules/pip { };
-
-  pluggy = disabled super.pluggy;
-
-  pycairo = disabled super.pycairo;
-
-  pyparsing = disabled super.pyparsing;
-
-  pytest = disabled super.pytest;
-
-  pytest_4 = disabled super.pytest;
-
-  pytest-xdist = disabled super.pytest-xdist;
-
-  recoll = disabled super.recoll;
-
-  rivet = disabled super.rivet;
-
-  rpm = disabled super.rpm;
-
-  setuptools = callPackage ../development/python2-modules/setuptools { };
-
-  six = disabled super.six;
-
-  wcwidth = disabled super.wcwidth;
-
-  wheel = callPackage ../development/python2-modules/wheel { };
-
-  zeek = disabled super.zeek;
-
-  zipp = disabled super.zipp;
-}