diff --git a/pkgs/applications/video/deface/default.nix b/pkgs/applications/video/deface/default.nix
new file mode 100644
index 000000000000..43c009c9dbb8
--- /dev/null
+++ b/pkgs/applications/video/deface/default.nix
@@ -0,0 +1,56 @@
+{ lib
+, stdenv
+, python3
+, fetchFromGitHub
+, makeWrapper
+, pkgs
+}:
+
+python3.pkgs.buildPythonApplication rec {
+  pname = "deface";
+  version = "1.4.0";
+  format = "pyproject";
+
+  src = fetchFromGitHub {
+    owner = "ORB-HD";
+    repo = "deface";
+    rev = "v${version}";
+    hash = "sha256-tLNTgdnKKmyYHVajz0dHIb7cvC1by5LQ5CFIbMvPEYk=";
+  };
+
+  nativeBuildInputs = with python3.pkgs; [
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = with python3.pkgs; [
+    imageio
+    imageio-ffmpeg
+    numpy
+    onnx
+    onnxruntime # Nixpkgs onnxruntime is missing CUDA support
+    opencv4
+    scikit-image
+    tqdm
+  ];
+
+  # Native onnxruntime lib used by Python module onnxruntime can't find its other libs without this
+  makeWrapperArgs = [
+    ''--prefix LD_LIBRARY_PATH : "${lib.makeLibraryPath [ pkgs.onnxruntime ]}"''
+  ];
+
+  patchPhase = ''
+    substituteInPlace pyproject.toml requirements.txt --replace "opencv-python" "opencv"
+  '';
+
+  # Let setuptools know deface version
+  SETUPTOOLS_SCM_PRETEND_VERSION = "v${version}";
+
+  pythonImportsCheck = [ "deface" "onnx" "onnxruntime" ];
+
+  meta = with lib; {
+    description = "Video anonymization by face detection";
+    homepage = "https://github.com/ORB-HD/deface";
+    license = licenses.mit;
+    maintainers = with maintainers; [ lurkki ];
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 3e94d75af142..17ea9103368c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -41865,6 +41865,8 @@ with pkgs;
 
   ov = callPackage ../tools/text/ov { };
 
+  deface = callPackage ../applications/video/deface { };
+
   tubekit = callPackage ../applications/networking/cluster/tubekit/wrapper.nix { };
 
   tubekit-unwrapped = callPackage ../applications/networking/cluster/tubekit { };