diff --git a/pkgs/development/python-modules/python-on-whales/default.nix b/pkgs/development/python-modules/python-on-whales/default.nix
new file mode 100644
index 000000000000..c2484a8857dd
--- /dev/null
+++ b/pkgs/development/python-modules/python-on-whales/default.nix
@@ -0,0 +1,45 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, setuptools
+, pythonOlder
+, pydantic
+, requests
+, tqdm
+, typer
+}:
+
+buildPythonPackage rec {
+  pname = "python-on-whales";
+  version = "0.65.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "gabrieldemarmiesse";
+    repo = "python-on-whales";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-aFE4qeNMSxhHs7IAjYQYl15s4NkHH8balTV3N0obNPs=";
+  };
+
+  nativeBuildInputs = [ setuptools ];
+
+  propagatedBuildInputs = [
+    pydantic
+    requests
+    tqdm
+    typer
+  ];
+
+  doCheck = false;  # majority of tests require Docker and/or network access
+  pythonImportsCheck = [ "python_on_whales" ];
+
+  meta = with lib; {
+    description = "Docker client for Python, designed to be fun and intuitive";
+    homepage = "https://github.com/gabrieldemarmiesse/python-on-whales";
+    changelog = "https://github.com/gabrieldemarmiesse/python-on-whales/releases/tag/v${version}";
+    license = licenses.mit;
+    maintainers = with maintainers; [ bcdarwin ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index a9c69321a06c..73bd3bb17c1f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11502,6 +11502,8 @@ self: super: with self; {
 
   python-olm = callPackage ../development/python-modules/python-olm { };
 
+  python-on-whales = callPackage ../development/python-modules/python-on-whales { };
+
   python-opendata-transport = callPackage ../development/python-modules/python-opendata-transport { };
 
   python-openstackclient = callPackage ../development/python-modules/python-openstackclient { };