diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 35938794696a..083c33cee838 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -604,7 +604,8 @@ stdenv.mkDerivation (finalAttrs: {
       export CFLAGS_NODIST="-fno-semantic-interposition"
     '';
 
-  hardeningEnable = [ "pie" ];
+  # Our aarch64-linux bootstrap files lack Scrt1.o, which fails the config test
+  hardeningEnable = lib.optionals (!withMinimalDeps && !stdenv.hostPlatform.isAarch64) [ "pie" ];
 
   setupHook = python-setup-hook sitePackages;