diff --git a/pkgs/development/python-modules/pyoprf/default.nix b/pkgs/development/python-modules/pyoprf/default.nix
new file mode 100644
index 000000000000..317533daa588
--- /dev/null
+++ b/pkgs/development/python-modules/pyoprf/default.nix
@@ -0,0 +1,54 @@
+{
+  lib,
+  stdenv,
+  buildPythonPackage,
+  liboprf,
+  setuptools,
+  pysodium,
+  securestring,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "pyoprf";
+  pyproject = true;
+
+  inherit (liboprf)
+    version
+    src
+    ;
+
+  postPatch =
+    let
+      soext = stdenv.hostPlatform.extensions.sharedLibrary;
+    in
+    ''
+      substituteInPlace ./pyoprf/__init__.py --replace-fail \
+        "ctypes.util.find_library('oprf') or ctypes.util.find_library('liboprf')" "'${lib.getLib liboprf}/lib/liboprf${soext}'"
+    '';
+
+  sourceRoot = "${src.name}/python";
+
+  build-system = [ setuptools ];
+
+  dependencies = [
+    pysodium
+    securestring
+  ];
+
+  pythonImportsCheck = [ "pyoprf" ];
+
+  nativeCheckInputs = [ pytestCheckHook ];
+
+  pytestFlagsArray = [ "tests/test.py" ];
+
+  meta = {
+    inherit (liboprf.meta)
+      description
+      homepage
+      changelog
+      license
+      teams
+      ;
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ed904bfd451f..ee90764b4e6e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -13508,6 +13508,8 @@ self: super: with self; {
 
   pyoppleio-legacy = callPackage ../development/python-modules/pyoppleio-legacy { };
 
+  pyoprf = callPackage ../development/python-modules/pyoprf { };
+
   pyorc = callPackage ../development/python-modules/pyorc { };
 
   pyorthanc = callPackage ../development/python-modules/pyorthanc { };