diff --git a/pkgs/development/python-modules/pandas/default.nix b/pkgs/development/python-modules/pandas/default.nix
index 54ad2eaf724f..dad1d4499ef7 100644
--- a/pkgs/development/python-modules/pandas/default.nix
+++ b/pkgs/development/python-modules/pandas/default.nix
@@ -90,6 +90,10 @@ buildPythonPackage rec {
     "test_comparison_invalid"
     # AssertionError: Regex pattern '"quotechar" must be string, not int'
     "python-kwargs2"
+    # Tests for rounding errors and fails if we have better precision
+    # than expected, e.g. on amd64 with FMA or on arm64
+    # https://github.com/pandas-dev/pandas/issues/38921
+    "test_rolling_var_numerical_issues"
   ] ++ lib.optionals stdenv.isDarwin [
     "test_locale"
     "test_clipboard"