diff --git a/pkgs/tools/networking/mu/default.nix b/pkgs/tools/networking/mu/default.nix
index 6a578b472398..9a4d47808a77 100644
--- a/pkgs/tools/networking/mu/default.nix
+++ b/pkgs/tools/networking/mu/default.nix
@@ -31,6 +31,17 @@ stdenv.mkDerivation rec {
       --replace "/bin/rm" "${coreutils}/bin/rm"
   '';
 
+  # AOT native-comp, mostly copied from pkgs/build-support/emacs/generic.nix
+  postInstall = lib.optionalString (emacs.nativeComp or false) ''
+    mkdir -p $out/share/emacs/native-lisp
+    export EMACSLOADPATH=$out/share/emacs/site-lisp/mu4e:
+    export EMACSNATIVELOADPATH=$out/share/emacs/native-lisp:
+
+    find $out/share/emacs -type f -name '*.el' -print0 \
+      | xargs -0 -I {} -n 1 -P $NIX_BUILD_CORES sh -c \
+          "emacs --batch --eval '(setq large-file-warning-threshold nil)' -f batch-native-compile {} || true"
+  '';
+
   buildInputs = [ emacs glib gmime3 texinfo xapian ];
 
   mesonFlags = [