diff --git a/pkgs/development/compilers/gcc/4.8/default.nix b/pkgs/development/compilers/gcc/4.8/default.nix
index 0105a159877a..36adfd075df2 100644
--- a/pkgs/development/compilers/gcc/4.8/default.nix
+++ b/pkgs/development/compilers/gcc/4.8/default.nix
@@ -169,7 +169,7 @@ let version = "4.8.5";
           # To keep ABI compatibility with upstream mingw-w64
           "--enable-fully-dynamic-string"
         ] else
-          optionals (targetPlatform.libc == "uclibc") [
+          optionals (targetPlatform.libc == "uclibc" || targetPlatform.libc == "musl") [
             # In uclibc cases, libgomp needs an additional '-ldl'
             # and as I don't know how to pass it, I disable libgomp.
             "--disable-libgomp"
diff --git a/pkgs/development/compilers/gcc/4.9/default.nix b/pkgs/development/compilers/gcc/4.9/default.nix
index 1b1492686d0e..c436da678fd9 100644
--- a/pkgs/development/compilers/gcc/4.9/default.nix
+++ b/pkgs/development/compilers/gcc/4.9/default.nix
@@ -160,7 +160,7 @@ let version = "4.9.4";
           # To keep ABI compatibility with upstream mingw-w64
           "--enable-fully-dynamic-string"
         ] else
-          optionals (targetPlatform.libc == "uclibc") [
+          optionals (targetPlatform.libc == "uclibc" || targetPlatform.libc == "musl") [
             # libsanitizer requires netrom/netrom.h which is not
             # available in uclibc.
             "--disable-libsanitizer"
diff --git a/pkgs/development/compilers/gcc/5/default.nix b/pkgs/development/compilers/gcc/5/default.nix
index 0636ce7381ae..ea59d2826e24 100644
--- a/pkgs/development/compilers/gcc/5/default.nix
+++ b/pkgs/development/compilers/gcc/5/default.nix
@@ -160,7 +160,7 @@ let version = "5.5.0";
           # To keep ABI compatibility with upstream mingw-w64
           "--enable-fully-dynamic-string"
         ] else
-          optionals (targetPlatform.libc == "uclibc") [
+          optionals (targetPlatform.libc == "uclibc" || targetPlatform.libc == "musl") [
             # libsanitizer requires netrom/netrom.h which is not
             # available in uclibc.
             "--disable-libsanitizer"
diff --git a/pkgs/development/compilers/gcc/6/default.nix b/pkgs/development/compilers/gcc/6/default.nix
index 2614e96e1b7c..91088a612333 100644
--- a/pkgs/development/compilers/gcc/6/default.nix
+++ b/pkgs/development/compilers/gcc/6/default.nix
@@ -158,7 +158,7 @@ let version = "6.4.0";
           # To keep ABI compatibility with upstream mingw-w64
           "--enable-fully-dynamic-string"
         ] else
-          optionals (targetPlatform.libc == "uclibc") [
+          optionals (targetPlatform.libc == "uclibc" || targetPlatform.libc == "musl") [
             # libsanitizer requires netrom/netrom.h which is not
             # available in uclibc.
             "--disable-libsanitizer"
@@ -399,6 +399,7 @@ stdenv.mkDerivation ({
       # On Illumos/Solaris GNU as is preferred
       "--with-gnu-as" "--without-gnu-ld"
     ]
+    ++ optional (targetPlatform == hostPlatform && targetPlatform.libc == "musl") "--disable-libsanitizer"
   ;
 
   targetConfig = if targetPlatform != hostPlatform then targetPlatform.config else null;
diff --git a/pkgs/development/compilers/gcc/7/default.nix b/pkgs/development/compilers/gcc/7/default.nix
index 0e5f69c27262..267e660e12d7 100644
--- a/pkgs/development/compilers/gcc/7/default.nix
+++ b/pkgs/development/compilers/gcc/7/default.nix
@@ -156,7 +156,7 @@ let version = "7.3.0";
           # To keep ABI compatibility with upstream mingw-w64
           "--enable-fully-dynamic-string"
         ] else
-          optionals (targetPlatform.libc == "uclibc") [
+          optionals (targetPlatform.libc == "uclibc" || targetPlatform.libc == "musl") [
             # libsanitizer requires netrom/netrom.h which is not
             # available in uclibc.
             "--disable-libsanitizer"