diff --git a/pkgs/tools/networking/mu/default.nix b/pkgs/tools/networking/mu/default.nix
index 4cd5318acf5c..98dec71f456b 100644
--- a/pkgs/tools/networking/mu/default.nix
+++ b/pkgs/tools/networking/mu/default.nix
@@ -21,8 +21,11 @@ stdenv.mkDerivation rec {
   '';
 
   buildInputs = [
-    sqlite xapian glib gmime3 texinfo emacs guile libsoup icu
-  ] ++ stdenv.lib.optionals withMug [ gtk3 webkitgtk ];
+    sqlite xapian glib gmime3 texinfo emacs libsoup icu
+  ]
+    # Workaround for https://github.com/djcb/mu/issues/1641
+    ++ stdenv.lib.optional (!stdenv.isDarwin) guile
+    ++ stdenv.lib.optionals withMug [ gtk3 webkitgtk ];
 
   nativeBuildInputs = [ pkgconfig autoreconfHook pmccabe ];