diff --git a/pkgs/development/python-modules/pyopenssl/default.nix b/pkgs/development/python-modules/pyopenssl/default.nix
index 3b225ad721ea..16bfddc8340a 100644
--- a/pkgs/development/python-modules/pyopenssl/default.nix
+++ b/pkgs/development/python-modules/pyopenssl/default.nix
@@ -47,6 +47,8 @@ let
     "test_fallback_default_verify_paths"
     # https://github.com/pyca/pyopenssl/issues/768
     "test_wantWriteError"
+    # https://github.com/pyca/pyopenssl/issues/1043
+    "test_alpn_call_failure"
   ] ++ (
     lib.optionals (lib.hasPrefix "libressl" openssl.meta.name) failingLibresslTests
   ) ++ (