diff --git a/pkgs/by-name/me/meshlab/no-plist.patch b/pkgs/by-name/me/meshlab/no-plist.patch
new file mode 100644
index 000000000000..7c8d753190a8
--- /dev/null
+++ b/pkgs/by-name/me/meshlab/no-plist.patch
@@ -0,0 +1,12 @@
+--- src/meshlab/CMakeLists.txt.orig	2025-10-05 23:04:12.786192073 +0200
++++ src/meshlab/CMakeLists.txt	2025-10-05 23:04:16.379256637 +0200
+@@ -92,9 +92,6 @@
+ 		MACOSX_BUNDLE_COPYRIGHT "Copyright VCG-ISTI-CNR © 2005-2021. All rights reserved."
+ 		)
+ 	
+-	set_additional_settings_info_plist(
+-		TARGET meshlab
+-		FILE ${MESHLAB_BUILD_DISTRIB_DIR}/meshlab.app/Contents/Info.plist)
+ endif()
+ 
+ install(
diff --git a/pkgs/by-name/me/meshlab/package.nix b/pkgs/by-name/me/meshlab/package.nix
index 0be074cf79e1..9e431b24d75d 100644
--- a/pkgs/by-name/me/meshlab/package.nix
+++ b/pkgs/by-name/me/meshlab/package.nix
@@ -102,19 +102,14 @@ stdenv.mkDerivation (finalAttrs: {
     # ref. https://github.com/cnr-isti-vclab/meshlab/pull/1617
     # merged upstream
     ./1617_cmake-use-system-dependencies-install-exports.patch
+  ]
+  ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    ./no-plist.patch
   ];
 
-  postPatch =
-    lib.optionalString stdenv.hostPlatform.isLinux ''
-      substituteAll ${./meshlab.desktop} resources/linux/meshlab.desktop
-    ''
-    + lib.optionalString stdenv.hostPlatform.isDarwin ''
-      substituteInPlace src/meshlab/CMakeLists.txt \
-        --replace-fail "set_additional_settings_info_plist(" "# set_additional_settings_info_plist(" \
-        --replace-fail "	TARGET meshlab" "#	TARGET meshlab" \
-        --replace-fail "	FILE \''${MESHLAB_BUILD_DISTRIB_DIR}/meshlab.app/Contents/Info.plist)" \
-                       "#	FILE \''${MESHLAB_BUILD_DISTRIB_DIR}/meshlab.app/Contents/Info.plist)"
-    '';
+  postPatch = lib.optionalString stdenv.hostPlatform.isLinux ''
+    substituteAll ${./meshlab.desktop} resources/linux/meshlab.desktop
+  '';
 
   cmakeFlags = cmakeFlagsDisallowDownload;