diff --git a/pkgs/development/libraries/openssl/3.5/openssl-aes-gcm-ppc-remove-localentry-directive.patch b/pkgs/development/libraries/openssl/3.5/openssl-aes-gcm-ppc-remove-localentry-directive.patch
new file mode 100644
index 000000000000..43e6d333844d
--- /dev/null
+++ b/pkgs/development/libraries/openssl/3.5/openssl-aes-gcm-ppc-remove-localentry-directive.patch
@@ -0,0 +1,65 @@
+From 5aaa7e5fdc59e88a13d2911cb86d814d4e2669da Mon Sep 17 00:00:00 2001
+From: Danny Tsen <dtsen@us.ibm.com>
+Date: Wed, 28 Jan 2026 07:23:13 -0500
+Subject: [PATCH] aes-gcm-ppc.pl: Removed .localentry directive
+
+Otherwise there is mixing of  ELFv1 ABI and ELFv2 ABI directives
+and PPC64 big endian builds fail.
+
+Fixes #29815
+
+Signed-off-by: Danny Tsen <dtsen@us.ibm.com>
+
+Reviewed-by: Paul Dale <paul.dale@oracle.com>
+Reviewed-by: Shane Lontis <shane.lontis@oracle.com>
+Reviewed-by: Tomas Mraz <tomas@openssl.org>
+MergeDate: Tue Feb  3 08:39:50 2026
+(Merged from https://github.com/openssl/openssl/pull/29827)
+---
+ crypto/modes/asm/aes-gcm-ppc.pl | 5 -----
+ 1 file changed, 5 deletions(-)
+
+diff --git a/crypto/modes/asm/aes-gcm-ppc.pl b/crypto/modes/asm/aes-gcm-ppc.pl
+index 68918a9305a2b..fd5dcc22a6117 100644
+--- a/crypto/modes/asm/aes-gcm-ppc.pl
++++ b/crypto/modes/asm/aes-gcm-ppc.pl
+@@ -409,7 +409,6 @@
+ ################################################################################
+ .align 4
+ aes_gcm_crypt_1x:
+-.localentry	aes_gcm_crypt_1x,0
+ 
+ 	cmpdi	5, 16
+ 	bge	__More_1x
+@@ -492,7 +491,6 @@
+ ################################################################################
+ .align 4
+ __Process_partial:
+-.localentry	__Process_partial,0
+ 
+ 	# create partial mask
+ 	vspltisb 16, -1
+@@ -564,7 +562,6 @@
+ .global ppc_aes_gcm_encrypt
+ .align 5
+ ppc_aes_gcm_encrypt:
+-.localentry     ppc_aes_gcm_encrypt,0
+ 
+ 	SAVE_REGS
+ 	LOAD_HASH_TABLE
+@@ -752,7 +749,6 @@
+ .global ppc_aes_gcm_decrypt
+ .align 5
+ ppc_aes_gcm_decrypt:
+-.localentry	ppc_aes_gcm_decrypt, 0
+ 
+ 	SAVE_REGS
+ 	LOAD_HASH_TABLE
+@@ -1032,7 +1028,6 @@
+ .size   ppc_aes_gcm_decrypt,.-ppc_aes_gcm_decrypt
+ 
+ aes_gcm_out:
+-.localentry	aes_gcm_out,0
+ 
+ 	mr	3, 11			# return count
+ 
diff --git a/pkgs/development/libraries/openssl/default.nix b/pkgs/development/libraries/openssl/default.nix
index 4d6913e02494..541ba75ff1a6 100644
--- a/pkgs/development/libraries/openssl/default.nix
+++ b/pkgs/development/libraries/openssl/default.nix
@@ -482,6 +482,10 @@ in
         else
           ./3.5/use-etc-ssl-certs.patch
       )
+
+      # Don't cause ELF ABI mismatch on powerpc64
+      # https://github.com/openssl/openssl/issues/29815
+      ./3.5/openssl-aes-gcm-ppc-remove-localentry-directive.patch
     ]
     ++ lib.optionals stdenv.hostPlatform.isMinGW [
       ./3.5/fix-mingw-linking.patch
@@ -518,6 +522,10 @@ in
         else
           ./3.5/use-etc-ssl-certs.patch
       )
+
+      # Don't cause ELF ABI mismatch on powerpc64
+      # https://github.com/openssl/openssl/issues/29815
+      ./3.5/openssl-aes-gcm-ppc-remove-localentry-directive.patch
     ]
     ++ lib.optionals stdenv.hostPlatform.isMinGW [
       # Fix from https://github.com/openssl/openssl/pull/29826