diff --git a/pkgs/development/python-modules/prometheus-client/default.nix b/pkgs/development/python-modules/prometheus-client/default.nix
index 19477b659b56..96b9a8f8077e 100644
--- a/pkgs/development/python-modules/prometheus-client/default.nix
+++ b/pkgs/development/python-modules/prometheus-client/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   fetchFromGitHub,
   setuptools,
@@ -32,6 +33,11 @@ buildPythonPackage rec {
 
   pythonImportsCheck = [ "prometheus_client" ];
 
+  disabledTests = lib.optionals stdenv.hostPlatform.isDarwin [
+    # fails in darwin sandbox: Operation not permitted
+    "test_instance_ip_grouping_key"
+  ];
+
   meta = with lib; {
     description = "Prometheus instrumentation library for Python applications";
     homepage = "https://github.com/prometheus/client_python";