diff --git a/pkgs/development/python-modules/asyncua/default.nix b/pkgs/development/python-modules/asyncua/default.nix
index 7e36099f186c..0ad561ebfb9b 100644
--- a/pkgs/development/python-modules/asyncua/default.nix
+++ b/pkgs/development/python-modules/asyncua/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , aiofiles
 , aiosqlite
 , buildPythonPackage
@@ -60,6 +61,17 @@ buildPythonPackage rec {
     "asyncua"
   ];
 
+  disabledTests = lib.optionals stdenv.isDarwin [
+    # Failed: DID NOT RAISE <class 'asyncio.exceptions.TimeoutError'>
+    "test_publish"
+    # OSError: [Errno 48] error while attempting to bind on address ('127.0.0.1',...
+    "test_anonymous_rejection"
+    "test_certificate_handling_success"
+    "test_encrypted_private_key_handling_success"
+    "test_encrypted_private_key_handling_success_with_cert_props"
+    "test_encrypted_private_key_handling_failure"
+  ];
+
   meta = with lib; {
     description = "OPC UA / IEC 62541 Client and Server for Python";
     homepage = "https://github.com/FreeOpcUa/opcua-asyncio";