diff --git a/pkgs/by-name/pi/picard/package.nix b/pkgs/by-name/pi/picard/package.nix
index 392c80f1ec43..db9009ebaedf 100644
--- a/pkgs/by-name/pi/picard/package.nix
+++ b/pkgs/by-name/pi/picard/package.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   python312Packages,
   fetchFromGitHub,
 
@@ -40,27 +41,55 @@ pythonPackages.buildPythonApplication (finalAttrs: {
 
   buildInputs = [
     qt5.qtbase
+  ]
+  ++ lib.optionals (lib.meta.availableOn stdenv.hostPlatform qt5.qtwayland) [
     qt5.qtwayland
   ]
-  ++ lib.optionals (pyqt5.multimediaEnabled) [
-    qt5.qtmultimedia.bin
-    gst_all_1.gst-libav
-    gst_all_1.gst-plugins-base
-    gst_all_1.gst-plugins-good
-    gst_all_1.gst-vaapi
+  ++ lib.optionals (pyqt5.multimediaEnabled) (
+    [
+      qt5.qtmultimedia.bin
+      gst_all_1.gst-libav
+      gst_all_1.gst-plugins-base
+      gst_all_1.gst-plugins-good
+    ]
+    ++ lib.optionals (lib.meta.availableOn stdenv.hostPlatform gst_all_1.gst-vaapi) [
+      gst_all_1.gst-vaapi
+    ]
+  );
+
+  pythonRelaxDeps = lib.optionals stdenv.hostPlatform.isDarwin [
+    # Should be resolved in the next version
+    "pyobjc-core"
+    "pyobjc-framework-Cocoa"
   ];
 
-  propagatedBuildInputs = with pythonPackages; [
-    charset-normalizer
-    chromaprint
-    discid
-    fasteners
-    markdown
-    mutagen
-    pyjwt
-    pyqt5
-    python-dateutil
-    pyyaml
+  propagatedBuildInputs =
+    with pythonPackages;
+    [
+      charset-normalizer
+      chromaprint
+      discid
+      fasteners
+      markdown
+      mutagen
+      pyjwt
+      pyqt5
+      python-dateutil
+      pyyaml
+    ]
+    ++ lib.optionals stdenv.hostPlatform.isDarwin [
+      pyobjc-core
+      pyobjc-framework-Cocoa
+    ];
+
+  # Not reporting any of these issues because the next upstream version will
+  # include many breaking changes and this might not be relevant.
+  disabledTestPaths = lib.optionals stdenv.hostPlatform.isDarwin [
+    "test/test_const_appdirs.py::AppPathsTest::test_cache_folder_macos" # - AssertionError: '/nix/var/nix/builds/nix-54642-966088698/.h[33 chars]card' ...
+    "test/test_const_appdirs.py::AppPathsTest::test_config_folder_macos" # - AssertionError: '/nix/var/nix/builds/nix-54642-966088698/.h[38 chars]card' ...
+    "test/test_const_appdirs.py::AppPathsTest::test_plugin_folder_macos" # - AssertionError: '/nix/var/nix/builds/nix-54642-966088698/.h[46 chars]gins' ...
+    "test/test_plugins.py" # Various PermissionError for /var/empty/Library - hopefully will be resolved in the next release.
+    "test/test_utils.py::HiddenFileTest::test_macos" # - FileNotFoundError: [Errno 2] No such file or directory: 'SetFile'
   ];
 
   setupPyGlobalFlags = [