diff --git a/pkgs/development/python-modules/rdkit/default.nix b/pkgs/development/python-modules/rdkit/default.nix
index 07c18b5463a8..470cc1e22e8c 100644
--- a/pkgs/development/python-modules/rdkit/default.nix
+++ b/pkgs/development/python-modules/rdkit/default.nix
@@ -1,4 +1,5 @@
 { lib
+, stdenv
 , buildPythonPackage
 , fetchFromGitHub
 , cmake
@@ -15,6 +16,7 @@
 , numpy
 , pandas
 , pillow
+, memorymappingHook
 }:
 let
   external = {
@@ -82,6 +84,8 @@ buildPythonPackage rec {
   buildInputs = [
     boost
     cairo
+  ] ++ lib.optionals (stdenv.system == "x86_64-darwin") [
+    memorymappingHook
   ];
 
   propagatedBuildInputs = [
@@ -149,7 +153,7 @@ buildPythonPackage rec {
 
   meta = with lib; {
     description = "Open source toolkit for cheminformatics";
-    maintainers = [ maintainers.rmcgibbo ];
+    maintainers = with maintainers; [ rmcgibbo natsukium ];
     license = licenses.bsd3;
     homepage = "https://www.rdkit.org";
   };
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 7711612668fe..afaabefd8e1d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10353,7 +10353,12 @@ self: super: with self; {
 
   rdflib = callPackage ../development/python-modules/rdflib { };
 
-  rdkit = callPackage ../development/python-modules/rdkit { };
+  rdkit = callPackage ../development/python-modules/rdkit {
+    boost = pkgs.boost182.override {
+      enablePython = true;
+      inherit python;
+    };
+  };
 
   re-assert = callPackage ../development/python-modules/re-assert { };